Clinical factors associated with unfavorable outcomes in HIV-positive tuberculosis patients-Reference-Cited by-同舟云学术

Clinical factors associated with unfavorable outcomes in HIV-positive tuberculosis patients

Published:2021-11-05 Issue:10 Volume:99 Page:28-34
ISSN:2542-1506
Container-title:Tuberculosis and Lung Diseases
language:
Short-container-title:Tuberk. bolezni lëgk.

Author:

Borovitskiy V. S.¹,Sinitsyn M. V.²

Affiliation:

1. Medical Unit of Penal Colony no. 43 by Federal Prosecution Service; Kirov State Medical University

2. Moscow Municipal Scientiﬁc Practical Center for Tuberculosis Control of Moscow Health Department

Abstract

The objective: to identify clinical factors with the highest sensitivity and speciﬁcity associated with an unfavorable outcome in the patient with tuberculosis and HIV infection.Subjects. 363 patients with TB/HIV co-infection. Group 1 – 59 (16.3%) patients with the unfavorable outcome, Group 2 – 304 (83.7%) patients with a favorable outcome.Methods: analysis of paired contingency tables by Pearson criterion, quantitative signs by Mann – Whitney test, simple and multiple logistic regression.Results. The following factors promoting unfavorable outcomes in the patient with TB/HIV co-infection with the highest sensitivity and speciﬁcity were identiﬁed: hemoglobin level (sensitivity – 78.0%; speciﬁcity – 73.7%), gastrointestinal candidiasis (72.9% and 84.5%), loose stool (40.7% and 97.4%), no lymphadenopathy (89.8% and 57.2%), and headache (49.2% and 88.5%). The combination of these clinical manifestations provides sensitivity of 78.0% and speciﬁcity of 94.4%.A formula is proposed for calculating the probability of an unfavorable outcome in the patient TB/HIV co-infection.

Publisher

New Terra

Subject

General Medicine

Reference16 articles.

1. Kaminskiy G.D., Kudlay D.А., Panova А.E., Parolina L.E., Peregudova А.B., Pshenichnaya N.Yu., Samoylova А.G., Testov V.V., Tinkova V.V. Taktika vracha pri vyyavlenii, diagnostike i profilaktike sochetannoy infektsii VICH i tuberkulez: prakticheskoe rukovodstvo [Tactics of the physician in the detection, diagnosis and prevention of TB/HIV coinfection. Practical guide]. I.A. Vasilyeva, eds., Moscow, 2020, 152 p.

2. Lang T.A., Secic M. Kak opisyvat statistiku v meditsine. Rukovodstvo dlya avtorov, redaktorov i retsenzentov. (Russ. Ed.: T.A. Lang, M. Secic. How to Report Statistics in Medicine: Annotated Guidelines for Authors, Editors, and Reviewers), V.P. Leonov, eds., Moscow, Prakticheskaya Meditsina Publ., 2011, 480 p.

3. Petrie A., Sabin S. Naglyadnaya meditsinskaya statistika. (Russ. Ed.: Petrie A., Sabin S. Medical statistics at a glance). V.P. Leonov, eds., 2nd Edition, reviewed and supplemented, Moscow, GEOTAR-Media Publ., 2009, 168 p.

4. Abdullahi O.A., Ngari M.M., Sanga D., Katana G., Willetts A. Mortality during treatment for tuberculosis; a review of surveillance data in a rural county in Kenya. PLoS One, 2019, vol. 14, no. 7, pp. 0219191.

5. Chan C.K., Wong K.H., Lee M.P., Chan K.C., Leung C.C., Leung E.C., ChanW.K., Mak I.K. Risk factors associated with 1-year mortality among patients with HIV-associated tuberculosis in areas with intermediate tuberculosis burden and low HIV prevalence. Hong Kong Med. J., 2018, vol. 24, no. 5, pp. 473-483.

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