Affiliation:
1. V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University
2. Institute of Internal and Preventive Medicine, the Branch of Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences
Abstract
The objective of the study: to study rs2227983 polymorphism of EGFR gene in patients with allergic asthma and healthy individuals.Subjects and Methods. 179 patients suffering from allergic asthma were included in the study. The diagnosis and degree of severity were established in accordance with the GINA recommendations. The Control Group included apparently healthy individuals (n = 217). Patients with allergic asthma underwent standard laboratory and instrumental examinations and DNA typing.Results. A statistically significant predominance of AG genotype frequency in the group of patients with allergic asthma, including women, versus the group of healthy individuals, was established. AG rs2227983 genotype of EGFR gene was found to be significantly more common in patients with mild and moderate allergic asthma including women, than in healthy individuals, including women.Conclusion. The association of rs2227983 polymorphism of EGFR gene with allergic asthma has been established. A homozygous GG genotype may play a protective role against the disease.
Publisher
LLC "Medical Knowledge and Technologies"
Reference20 articles.
1. Genetika bronkholegochnykh zabolevaniy. [Genetics of bronchopulmonary diseases]. V.P. Puzyrev, L.M. Ogorodova, eds., Moscow, Atmoshera Publ., 2010, 160 p.
2. Lebedenko А.А., Shkurat T.P., Mashkina E.V., Semernik O.E., Dreyzina T.K. An analysis of association between growth factor gene polymorphisms and the risk of bronchial asthma in children. Pulmonologiya, 2018, vol. 28, no. 1, pp. 7-12. (In Russ.) doi: org/10.18093/0869-0189-2018-28-1-7-12.
3. Mironova Zh.А., Trofimov V.I., Babadzhanova G.Yu. Genetika bronkhialnoy astmy. Respiratornaya meditisna. Rukovodstvo. [The genetics of bronchial asthma. Respiratory Medicine. Guidelines]. Chuchalin A.G., eds., 2nd ed., vol. 1, pp. 439-446.
4. Saltykova I.V., Freydin M.B., Bragina E.Yu. et al. Association of rs6737848 polymorphism of the SOCS5 gene with bronchial asthma. Vestnik Rossiiskoy Akademii Meditsinskikh Nauk, 2013, no. 7, pp. 53-56. (In Russ.)
5. Semernik O.E., Lebedenko А.А., Shkurat T.P., Mashkina E.V., Dreyzina T.K. The role of mutations in metalloproteinases and the epithelial growth factor receptor genes in the pathogenesis of children bronchial asthma. Pulmonologiya, 2020, vol. 30, no. 1, pp. 17-22. (In Russ.) doi: org/10.18093/0869-0189-2020-30-1-17-22.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献