The optimal modeling method of specific tuberculosis peritonitis (experimental research)-Reference-Cited by-同舟云学术

The optimal modeling method of specific tuberculosis peritonitis (experimental research)

Published:2022-01-12 Issue:12 Volume:99 Page:44-50
ISSN:2542-1506
Container-title:Tuberculosis and Lung Diseases
language:
Short-container-title:Tuberk. bolezni lëgk.

Author:

Plotkin D. V.¹^ORCID,Vinogradova T. I.²^ORCID,Reshetnikov M. N.³^ORCID,Zyuzya Yu. R.³^ORCID,Serdobintsev M. S.²^ORCID,Sinitsyn M. N.³^ORCID

Affiliation:

1. Moscow Municipal Scientific Practical Center of Tuberculosis Control; Pirogov Russian National Research Medical University

2. St. Petersburg Research Institute of Phthisiopulmonology

3. Moscow Municipal Scientific Practical Center of Tuberculosis Control

Abstract

The objective: to create a reproducible model of chronic tuberculosis peritonitis to study pathophysiological mechanisms of its progression and to develop pathogenetically based therapy.Subjects and Methods. The study was performed using 10 male rabbits of the Chinchilla breed. The animals were administered intraperitoneal culture of Mycobacterium tuberculosis, tuberculosis peritonitis modeling was performed according to the proposed method.Results. In the course of the experiment, it was proved that all animals developed tuberculous peritonitis with lesions of the large omentum and serous integuments of internal organs. Molecular genetic tests of fragments of the omentum and peritoneum detected DNA of Mycobacterium tuberculosis.

Publisher

LLC "Medical Knowledge and Technologies"

Subject

General Medicine

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