Arterial stiffness and albuminuria as markers of endothelial dysfunction in those with chronic obstructive pulmonary disease-Reference-Cited by-同舟云学术

Arterial stiffness and albuminuria as markers of endothelial dysfunction in those with chronic obstructive pulmonary disease

Published:2021-04-06 Issue:3 Volume:99 Page:34-40
ISSN:2542-1506
Container-title:Tuberculosis and Lung Diseases
language:
Short-container-title:Tuberk. bolezni lëgk.

Author:

Bakina A. A.¹^ORCID,Pavlenko V. A.¹,Naryshkina S. V.¹

Affiliation:

1. Amur State Medical Academy

Abstract

The objective: to assess the state of arterial stiffness and the level of albuminuria in patients with chronic obstructive pulmonary disease (COPD) and to investigate the presence and nature of the association of the studied parameters with clinical and laboratory parameters of COPD.Subjects and methods. 70 patients with COPD were examined, they all were divided into 4 groups depending on severity of clinical symptoms and number of exacerbations suffered in the previous 12 months. Additionally to standard examinations, albuminuria level, the pulse wave velocity in aorta (PWVa), and cardio-ankle vascular index (CAVI) were assessed.Results. The increased albuminuria level was registered in 51.4% of patients mainly suffering from frequent exacerbations. The increased CAVI and PWVa also prevailed in individuals with a high frequency of exacerbation and their higher levels were found in 37.1% and 14.3% of patients, respectively. PWVa and CAVI values were found to be associated with albuminuria level and clinical and laboratory parameters of COPD.

Publisher

New Terra

Subject

General Medicine

Reference16 articles.

1. Аgafonova O.V., Gritsenko T.А., Bogdanova Yu.V., Bulgakova S.V., Kosyakova Yu.А., Davydkin I., Danilova O.E., Dzyubaylo А.V., Dyachkov V.А., Zakharova N.O., Zolotovskaya I.А., Kolsanov А.V., Kotelnikov G.P., Krivova S.P., Kudlay D.А., Kupaev V.I., Kurtov I.V., Lebedeva E.А., Menzul E.V., Nazarkina I.M. et al. Poliklinicheskaya Terapiya. Uchebnik. [Polyclinic therapy. Handbook]. Davydkin I.L., Schukin Yu.V., eds., 2nd Edition, reviewed and supplemented, Moscow, GEOTAR-Media Publ., 2020, 840 p. ISBN 978-5-9704-5545-6.

2. Blinova T.V., Strakhova L.А., Lavrenyuk N.А., Umnyagina I.А. Serum cytokine profile in chronic obstructive pulmonary disease of occupational etiology in the stable phase of the disease and its association with other inflammation markers. Pulmonologiya, 2015, vol. 25, no. 5, pp. 566-573. (In Russ.) doi: 10.18093/0869-0189-2015-25-5-566-573.

3. Diagnostika, lecheniye, profilaktika ozhireniya i assotsiirovannykh s nim zabolevaniy. Natsionalnyye klinicheskiye rekomendatsii. [Diagnostics, treatment, prevention of obesity and associated diseases. National clinical guidelines]. Co-chairs E.V. Shlyakhto, S.V. Nedogoda, А.O. Konradi. St. Petersburg, 2017, 164 p.

4. Kulik E.G., Pavlenko V.I., Naryshkina S.V. Association of arterial stiffness with markers of vascular endothelial dysfunction and systemic inflammation in chronic obstructive pulmonary disease. Byulleten Fziologii i Patologii Organov Dykhaniya, 2018, Issue 67, pp. 31-36. (In Russ.) doi: 10.12737/article_5a9f273cb8bdc0.80232446.

5. Mamaev А.N., Kudlay D.А. Statisticheskiye metody v meditsine. [Statistical methods in medicine]. Moscow, Prakticheskaya Meditsina Publ., 2021, 136 p. ISBN 978-5-98811-635-6.