Assessment of the effect of alpha-tocopherol on the course of newly diagnosed pulmonary sarcoidosis: a comparative study

Author:

Vizel A. A.1,Culver D. A.2,Vizel I. Yu.3,Shakirova G. R.4,Bakunina E. A.5

Affiliation:

1. Kazan State Medical University

2. Department of Pulmonary Medicine, Respiratory Institute, Inflammation and Immunity Department, Lerner Research Institute, Cleveland Clinic

3. Kazan State Medical University; Central Tuberculosis Research Institute

4. Kazan State Medical University; Republican Clinical Hospital, the Ministry of Health of Tatarstan Republic

5. The Hospice Charity Fund «Vera»

Abstract

The objective: to compare the results of follow-up over patients with a mild form of pulmonary sarcoidosis who received alpha-tocopherol and those receiving no treatment. Subjects and methods. The results of follow-up over 80 sarcoidosis patients were retrospectively analyzed – two groups of 40 patients enrolled according to the copy – pair principle (gender, age, initial X-ray stage, Löfgren syndrome, and follow-up duration). The only sign that statistically distinguished the groups was a high frequency of complaints about weakness in those who received vitamin E – 55% versus 30% (p < 0.05). The follow-up period for patients in both groups was a year or more (a control point). The database was maintained and processed using SPSS-18, Windows 10. A clear advantage of vitamin E administration was revealed when comparing the data of computed tomography, which resulted in improvement in 87.5%, and the disease progressed in 2.5%, while in the group receiving no treatment – 60 and 12.5%, respectively. The OR of improvement in computed tomography with alpha-tocopherol versus the group receiving no treatment made 4.67 (95% CI, 1.51-14.46).Conclusion. The use of vitamin E in mild forms of thoracic sarcoidosis gives a better result compared to the group receiving no treatment.

Publisher

New Terra

Subject

General Medicine

Reference13 articles.

1. Kostina Z.I., Аfanasiev I.V., Grigorieva V.I. Sarkoidoz legkikh. [Pulmonary sarcoidosis]. Leningrad, Meditsina Publ., 1975, 186 p.

2. Raznatovskaya E.N. Integral indices of endogenous intoxication in patients with drug resistant pulmonary tuberculosis. Аktualnі Pitannya Farmatsevtichnoy I Medichnoy Nauki Ta Praktiki, 2012, vol. 9, no. 2, pp. 119-120.

3. Sarkaidoz. [Sarcoidosis]. А.G. Khomenko, O. Shvayger, eds., Moscow, Meditsina Publ., 1982, 296 p.

4. Tyumentseva Z.G., Tereshina L.S. A clinical case of successful treatment of sarcoidosis of the intrathoracic lymph nodes with alpha-tocopherol as monotherapy in out-patient settings. Zdravookhraneniye Dalnego Vostoka, 2008, vol. 4, no. 36, pp. 84-86. (In Russ.)

5. Atan D., İkincioğulları A., Köseoğlu S. et al. New predictive parameters of Bell's palsy: neutrophil to lymphocyte ratio and platelet to lymphocyte ratio. Balkan. Med. J., 2015, vol. 32, no. 2, pp. 167-170.

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