The problem of neurotoxicity of drugs in the treatment of tuberculosis patients

Author:

Mozhokina G. N.1,Samoylova A. G.1,Vasilyeva I. A.1

Affiliation:

1. National Medical Research Center of Phthisiopulmonology and Infectious Diseases

Abstract

The article presents the analysis of 36 publications about neurotoxic properties of anti-tuberculosis drugs, their clinical manifestations and mechanisms of the neurotoxic action. It specifies predisposing factors for the development of neurotoxicity and risk groups. It highlights the necessity of early detection of neurotoxicity caused by chemotherapy regimens for timely management and adequate treatment of patients.

Publisher

New Terra

Subject

General Medicine

Reference37 articles.

1. Balasanyants G.S., Sukhanov D.S. Pobochnye deystviya protivotuberkuleznykh preparatov i metody ikh ustraneniya. [Side effects to anti-tuberculosis drugs and methods of their management]. 3rd ed., revised, St. Petersburg, 2014, 64 p.

2. Vavilova А.А., Kochergin G.А. On the issue of the vestibular toxicity effect of aminoglycosides. RMJ, 2017, no. 6, pp. 435-438. (In Russ.)

3. Golubchikov P.N., Kruk E.А., Mishustin S.P., Petrenko T.I., Kudlay D.А. Experience of treating extensive drug resistant tuberculosis patients including continuous use of bedaquiline, in Tomsk Region: immediate and postponed results. Tuberculosis and Lung Diseases, 2019, vol. 97, no. 8, pp. 38-45. (In Russ.)

4. Ivanova D.А. Nezhelatelnye reaktsii pri lechenii vpervye vyyavlennykh bolnykh tuberkulezom organov dykhaniya: profilaktika, rannyaya diagnostika i kupirovanie. Avtoref. diss. dokt. med. nauk. [Adverse reactions to treatment of new respiratory tuberculosis cases: prevention, early diagnostics and management. Synopsis of Doct. Diss.]. Moscow, 2018. 44 p.

5. Ivanova D.А., Borisov S.E. Discontinue or wait ?: indications for cancellation of anti-tuberculosis drugs due to adverse reactions. Tuberculosis and Lung Diseases, 2018, vol. 96, no. 2, pp. 47-54. (In Russ.)

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