Reparation of lung tissue in newly detected pulmonary tuberculosis as genetically determined process-Reference-Cited by-同舟云学术

Reparation of lung tissue in newly detected pulmonary tuberculosis as genetically determined process

Published:2020-09-24 Issue:8 Volume:98 Page:7-13
ISSN:2542-1506
Container-title:Tuberculosis and Lung Diseases
language:
Short-container-title:Tuberk. bolezni lëgk.

Author:

Samsonov K. Yu.¹^ORCID,Mordyk A. V.¹^ORCID,Аroyan A. R.²^ORCID,Batischeva T. L.²^ORCID,Ivanova O. G.¹^ORCID

Affiliation:

1. Omsk State Medical University

2. Clinical TB Dispensary

Abstract

The objective of the study is to assess the effect of rs6707530 polymorphism of the FN1 gene and rs1150754 polymorphism of the TNXB gene on the healing of lung tissue destruction in patients with newly detected pulmonary tuberculosis.Subjects and methods. 82 patients older 18 years with newly diagnosed pulmonary tuberculosis with destruction were enrolled in the study. X-ray data were assessed on the 2nd, 4th and 6th months of the study. Patients were divided into 2 groups depending on the efficacy of chemotherapy intensive phase.Results. In the group of patients with an effective course of chemotherapy, the frequency of carriers of G allele (p < 0.001) and T/G genotype (p = 0.01) in rs6707530 locus of the FN1 gene was higher. While T/T genotype (p = 0.002) and T allele (p < 0.001) prevailed among the patients with persisting destruction of lung tissue after the intensive phase of chemotherapy.

Publisher

New Terra

Subject

General Medicine

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