IMPACT OF BEDAQUILINE ON THE EFFICIENCY OF COMPREHENSIVE THERAPY OF RESPIRATORY TUBERCULOSIS

Author:

Kondakova M. N.,Khabirov V. V.,Zhemkov V. F.,Shpakovskaya L. R.,Daynovets A. V.,Elkin A. V.

Abstract

The objective of the study:to evaluate the possibility to enhance the clinical efficiency of treatment of pulmonary tuberculosis patients by adding bedaquiline to the fifth chemotherapy regimen.Subjects and methods. The presented results were obtained through dynamic follow-up and treatment of 68 respiratory tuberculosis patients, treated in St. Petersburg TB Dispensary from 2014 to 2016.Results. The clinical improvement manifested through relief of intoxication symptoms, normalization of blood count, reduction of infiltrate changes and healing of destruction. In a number of cases, relief of intoxication symptoms with reduction of bacillary excretion massiveness, infiltration and cavity sizes allowed preparing patients for the next stage of treatment – surgery. 

Publisher

New Terra

Subject

General Medicine

Reference5 articles.

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2. Kofanov Yu.V., Doktorova N.P. Use of the new drug of bedaquiline in the therapy of drug resistant tuberculosis (a clinical case). Bulleten Meditsinskikh Internet Konferentsiy, 2015, vol. 5, no. 5, Available at: http://medconfer. com/node/5100 (In Russ.)

3. Morozova T.I., Otpuschennikova O.N., Doktorova N.P., Danilov А.N.Experience of using bedaquiline (Sirturo®) in the treatment of pulmonary tuberculosis patients with multiple drug resistance. Tuberculosis and Lung Diseases, 2016, no. 2, pp. 29-35. (In Russ.)

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5. Federalnye klinicheskiye rekomendatsii po diagnostike i lecheniyu tuberkuleza organov dykhaniya s mnozhestvennoy i shirokoy lekarstennoy ustoichivostyu vozbuditelya. [Federal clinical recommendations for diagnosis and treatment of respiratory tuberculosis with multiple and extensive drug resistance]. (Vasilyeva I.A., Aksenova V.A., Ergeshov A.E., Maryandyshev A.O., Samoylova A.G., Bagdasaryan T.R., Komissarova O.G., Lovacheva O.V., Perfiliev A.V., Karpina N.L. et al.) Moscow, OOO NEW TERRA PUBL., 2014, 52 p.

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