Some Aspects of Pituitary-Adrenal and Autonomic Nervous Systems Functioning in Patients with Chronic Consciousness Disorders-Reference-Cited by-同舟云学术

Some Aspects of Pituitary-Adrenal and Autonomic Nervous Systems Functioning in Patients with Chronic Consciousness Disorders

Published:2022-10-29 Issue:5 Volume:19 Page:63-70
ISSN:2541-8653
Container-title:Messenger of ANESTHESIOLOGY AND RESUSCITATION
language:
Short-container-title:Vestn. anesteziol. reanimatol.

Author:

Rybakov G. Yu.¹^ORCID,Kondratyeva E. A.¹^ORCID,Tsentsiper L. M.¹^ORCID,Denisova A. A.²^ORCID,Dryagina N. V.¹^ORCID,Lesteva N. A.¹^ORCID,Ivanova A. O.³^ORCID,Kondratyev A. N.¹^ORCID

Affiliation:

1. Polenov Neurosurgical Institute, the Branch of Almazov National Medical Research Center

2. Admiral Makarov State University of Maritime and Inland Shipping

3. D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology

Abstract

Patients with chronic disorders of consciousness (CDoC) have various variants of the pathological organization of functions including sympathetic hyperactivity and hormonal changes.The objective: to determine the severity of paroxysmal sympathetic hyperactivity (PSH), the function of the pituitary-adrenal system in patients with CDoC.Subjects and Methods. 54 patients with CDoC were enrolled in the study. Patients were randomized in the groups depending on assessment on the Coma Recovery Scale-Revised scale and CRS-R index calculation. PSH severity was assessed 7 times a day for two days. During the first week from the moment of admission, blood sampling was performed 7 times a day to study the levels of ACTH and cortisol.Results. PSH syndrome was detected in all groups, there were no significant dependencies of its severity on the time of day. There were no significant differences in the levels of ACTH and cortisol during the day.Conclusions: PSH syndrome is observed in most patients with CDoC. In patients with CDoC, the daily rhythm of ACTH and cortisol secretion are disrupted.

Publisher

FSBEI HE I.P. Pavlov SPbSMU MOH Russia

Subject

Anesthesiology and Pain Medicine,Critical Care and Intensive Care Medicine,Emergency Medicine

Reference23 articles.

1. Grechko A.V., Kiryachkov Yu.Yu., Petrova M.V. Modern aspects of the relationship between the functional state of the autonomic nervous system and clinical and laboratory indices of the body’s homeostasis in brain injuries. Vestnik Intensivnoy Terapii, 2018, no. 2, pp. 79-86. (In Russ.) doi: 10.21320/1818-474X-2018-2-79-86.

2. Kanarskiy M.M., Shtern M.V., Vorobieva I.S. et al. Circadian rhythms and chronic consciousness. Fizicheskaya i Reabilitatsionnaya Meditsina, Meditsinskaya Reabilitatsiya, 2021, vol. 3, no. 4, pp. 340-347. (In Russ.) doi: doi.org/10.36425/rehab63225.

3. Kondratyeva E.A., Dryagina N.V., Aybazova M.I. et al. Prognosis of prolonged disorders of consciousness outcome based on the determination of certain hormones and natriuretic peptide. Messenger of Anesthesiology and Resuscitation, 2019, vol. 16, no. 6, pp. 16-22. (In Russ.) doi: 10.21292/2078-5658-2019-16-6-16-22.

4. Piradov M.A., Suponeva N.A., Voznyuk I.A. et al. Chronic disorders of consciousness: terminology and diagnostic criteria. The results of the first meeting of the Russian Working Group for Chronic Disorders of Consciousness. Аnnaly Klinicheskoy i Eksperimentalnoy Nevrologii, 2020, vol. 14, no. 1, pp. 5-16. (In Russ.) doi: 10.25692/ACEN.2020.1.1.

5. Tsentsiper L.M. Gormonalnye narusheniya u bolnykh v vegetativnom sostoyanii. V kn. Vegetativnoye sostoyaniye. Etiologiya, patogenez, diagnostika. [Hormonal disorders in patients in a vegetative state. In: The vegetative state. Etiology, pathogenesis, and diagnosis]. E.A. Kondratyeva, I.V. Yakovenko, eds., SPb FGBU RNKHI Im. Prof. A. L. Polenova Publ., 2014, Ch. 10, pp. 217-227, ISBN 978-5-225-10023-0.