Guidelines of the Association of Anesthesiologists-Intensivists, the Interregional Non-Governmental Organization Alliance of Clinical Chemotherapists and Microbiologists, the Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy (IACMAC), and NGO Russian Sepsis Forum "Diagnostics and antimicrobial therapy of the infections caused by multiresistant microorganisms" (update 2022)

Author:

Beloborodov V. B.1,Goloschapov O. V.2,Gusarov V. G.3,Dekhnich А. V.4,Zamyatin M. N.5,Zubareva N. A.6,Zyryanov S. K.7,Kamyshova D. A.8,Klimko N. N.9,Kozlov R. S.10,Kulabukhov V. V.11,Petrushin M. A.12,Polushin Yu. S.13,Popov D. A.14,Rudnov V. A.15,Sidorenko S. V.16,Sokolov D. V.,Shlyk I. V.17,Edelshtein M. V.4,Yakovlev S. V.18

Affiliation:

1. Russian Medical Academy of On-going Professional Education

2. Institute of National Medical and Surgical Center named after N.I. Pirogov

3. Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation

4. Smolensk State Medical University

5. Federal State Budgetary Institution “N.I. Pirogov National Medical and Surgical Center"

6. E.A. Vagner Perm State Medical University

7. General and Clinical Pharmacology Faculty of Peoples’ Friendship University of Russia

8. National Medical and Surgical Center named after N.I. Pirogov

9. I.I. Mechnikov North-Western State Medical University

10. Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy (IACMAC); Antimicrobial Chemotherapy Research Institute of Smolensk State Medical University

11. N. V. Sklifosovsky Research Institute for Emergency Medicine

12. Regional Clinical Hospital

13. Pavlov First St. Petersburg State Medical University

14. Federal State Budgetary Institution "A.N. Bakulev National Medical Research Center of Cardiovascular Surgery"

15. Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy (IACMAC)

16. Interregional Non-Governmental Organization Alliance of Clinical Chemotherapists and Microbiologists; I.I. Mechnikov North-Western State Medical University

17. Clinic of Pavlov First St. Petersburg State Medical University

18. Interregional Non-Governmental Organization Alliance of Clinical Chemotherapists and Microbiologists; I.M. Sechenov First Moscow State Medical University (Sechenov University

Abstract

Strains of microorganisms characterized by resistance to antimicrobial drugs used in medical organizations continue to spread In most regions of the world including Russia. It is clear that it affects both the effectiveness of antimicrobial therapy and tactics and strategy of its use not only in adults patients but also in children. The pandemic of coronavirus infection, in addition, highlighted the growing problems in treatment of invasive mycoses, the dose adjustment of antibiotics during sorption and dialysis therapy methods. These circumstances made it necessary to make adjustments to Guidelines on Diagnostics and Antimicrobial Therapy of Infections Caused by Multiresistant Strains of Microorganisms, which were prepared by a group of leading Russian experts in 2020 [1]. The submitted version of the recommendations was approved on 25.03.2022 at a joint meeting of the working group with representatives of public organizations: Association of Anesthesiologists-Intensivists, the Interregional Non-Governmental Organization Alliance of Clinical Chemotherapists and Microbiologists, the Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy (IACMAC), and NGO Russian Sepsis Forum. These recommendations reflect an interdisciplinary consensus opinion on approaches to the diagnosis and antimicrobial therapy of infections caused by multiresistant microorganisms. They are based on data from publications obtained from randomized trials as well as based on international clinical guidelines with a high degree of evidence.It is rational to use the Guidelines for determining the tactics of empirical and etiotropic therapy of the most severe infections.

Publisher

FSBEI HE I.P. Pavlov SPbSMU MOH Russia

Subject

Anesthesiology and Pain Medicine,Critical Care and Intensive Care Medicine,Emergency Medicine

Reference68 articles.

1. Beloborodov V.B., Gusarov V.G., Dekhnich А.V., Zamyatin M.N., Zubareva N.А., Zyryanov S.K., Kamyshova D.А., Klimko N.N., Kozlov R.S., Kulabukhov V.V., Polushin Yu.S., Rudnov V.А., Sidorenko S.V., Shlyk I.V., Edelshteyn M.V., Yakovlev S.V. Diagnostics and antimicrobial therapy of the infections caused by multiresistant microorganisms. Guidelines. Messenger of Anesthesiology and Resuscitation, 2020, vol. 17, no. 1, pp. 52-83. (In Russ.) doi: 10.21292/2078-5658-2020-17-1-52-83.

2. Gusarov V.G., Lashenkova N.N., Petrova N.V. et al. Empirical antimicrobial treatment protocols as a tool to improve the quality of emergency medical care for patients with infection in a multidisciplinary surgical in-patient unit. Meditsinsky Alfavit, 2016, vol. 33, no. 4, Neotlozhnaya Meditsina, pp. 28-24. (In Russ.)

3. Diagnostika i lechenoye mikozov v otdeleniyakh reanimatsii i intensivenoy terapii. Rossiyskiye rekomendatsii. [Diagnostics and treatment of fungal infection in critical care departments. Russian national guidelines]. N.N. Klimko, eds., 2nd ed., suppl. and amend., Moscow, Farmtek Publ., 2015, 96 p.

4. Karpov O.E., Gusarov V.G., Zamyatin M.N., Orlova O.А., Petrova L.V., Kamyshova D.А., Dementienko M.V., Gaboyan Ya.S., Pivkina А.I., Gritsenko E.А. Management of antimicrobial resistance in a hospital: current state and future prospects. Klinicheskaya Mikrobiologiya i Antimikrobnaya Khimioterapiya, 2020, vol. 22, no. 4, pp. 277-286. (In Russ.) doi: 10.36488/cmac.2020.4.277-286.

5. Najgovzina N.V., Popova А.Yu., Biryukova E.E. et al. Optimization of activities aimed to control and prevent infections associated with medical care provision in the Russian Federation. ORGZDRAV, Novosti, Mneniya, Obuchenie, Vestnik VShOUZ, 2018, no. 1 (11), pp. 17–26. https://epidemiology-journal.ru/ru/archive/article/36040.

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