Hemodynamic Reactions during Removal of Brain Tumors with the Combined Use of Fentanyl and Alpha2-Adrenoagonist-Reference-Cited by-同舟云学术

Hemodynamic Reactions during Removal of Brain Tumors with the Combined Use of Fentanyl and Alpha2-Adrenoagonist

Published:2022-07-01 Issue:3 Volume:19 Page:25-32
ISSN:2541-8653
Container-title:Messenger of ANESTHESIOLOGY AND RESUSCITATION
language:
Short-container-title:Vestn. anesteziol. reanimatol.

Author:

Rumyantseva M. V.¹,Tsentsiper L. M.²,Kondratiev A. N.³

Affiliation:

1. North-Western District Scientific and Clinical Center Named after L. G. Sokolov

2. The Russian Neurosurgery Research Institute Named after A. L. Polenov, the Branch of Almazov National Medical Research Center; Institute of Experimental Medicine

3. The Russian Neurosurgery Research Institute Named after A. L. Polenov, the Branch of Almazov National Medical Research Center

Abstract

Anesthesia including drugs that act on the opioid (fentanyl) and adrenergic (clonidine or dexmedetomidine) neuroregulatory systems, creates optimal conditions for performing brain surgery.The objective: to study the effect of combination of opioid analgesic fentanyl and alpha2-adrenoagonists on stability (reactivity) and appropriate functional activity of the circulatory system.Subjects and Methods. The study included 118 patients operated on for a brain tumor. Patients were divided into groups depending on the alpha2-adrenoagonist used, its dosage and position on the operating table.Results. In all groups, the required level of neurovegetative stabilization with stable hemodynamics was achieved at all stages of the operation. Conclusion. Studies have shown that a lower dose of dexmedetomidine versus clonidine was required to achieve a central sympatho-modulatory effect.

Publisher

FSBEI HE I.P. Pavlov SPbSMU MOH Russia

Subject

Anesthesiology and Pain Medicine,Critical Care and Intensive Care Medicine,Emergency Medicine

Reference18 articles.

1. Аleksandrovich Yu.S., Pshenisnov K.V. Ingalyatsionnaya anesteziya u detey. Posobiye dlya vrachey. [Inhalation anesthesia in children. Doctors’ Manual]. St. Petersburg, 2020, p. 96.

2. Аnokhin P.K. Ocherki po fiziologii funktsionalnykh sistem. [Essays on functional systems physiology]. Moscow, 1975, pp. 17-59.

3. Gurskaya V.I., Dryagina N.V., Ivanov V.P. et al. Effect of general anesthesia on systemic inflammatory response and neuronal damage in children with craniosynostosis in perioperative period. Anesteziologiya i Reanimatologiya, 2021, no. 1, pp. 39-45. (In Russ.) doi: 10.17116/anaesthesiology202101139.

4. Deksdor: Instruktsiya po primeneniyu. [Dexdor. Use Instructions]. Orion Pharma. 2012. https://www.orionpharma.ru/contentassets/46024092870c4c64aec47d02099ec5ed/dexdor-100-g_ml-infusion-pil-pom-310719.pdf

5. Kondratiev А.N. Sochetannoye vozdeystviye na opioidnuyu i adrenergicheskuyu antinotsitseptivnyye sistemy v anesteziologicheskom obespechenii neyroonkologicheskikh operatsiy. Avtoref. diss. dokt. med. nauk. [Combined effects on the opioid and adrenergic antinociceptive systems in the anesthetic support of neurooncological surgery. Synopsis of Doct. Diss.]. St. Petersburg, 1992.

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The effect of dexmedetomidine on hemodynamic parameters during neuro-oncological surgery;Messenger of ANESTHESIOLOGY AND RESUSCITATION;2024-08-26