Effect of dalargin and remaxol on endocrine and metabolic disorders in patients with thoracoabdominal trauma-Reference-Cited by-同舟云学术

Effect of dalargin and remaxol on endocrine and metabolic disorders in patients with thoracoabdominal trauma

Published:2021-05-03 Issue:2 Volume:18 Page:69-76
ISSN:2541-8653
Container-title:Messenger of ANESTHESIOLOGY AND RESUSCITATION
language:
Short-container-title:Vestn. anesteziol. reanimatol.

Author:

Miroshnichenko A. G.¹,Rakhmanov R. M.²,Bolshakova M. A.²,Popov A. A.³,Popova E. A.³,Rakhmanova E. A.²,Shamov D. S.⁴,Lutsenko M. V.⁵,Khabarova O. I.⁶,Mamedov R. A.⁶

Affiliation:

1. I. I. Mechnikov North-Western State Medical University; Dzhanilidze St. Petersburg Research Institute of Emergency Care; Pavlov First Saint Petersburg State Medical University

2. V. F. Voyno-Yasenetsky State Medical University; Krasnoyarsk Interdistrict Clinical Hospital of Emergency Care Named after N. S. Karpovich

3. V. F. Voyno-Yasenetsky State Medical University; Krasnoyarsk Interdistrict Clinical Hospital of Emergency Care Named after N. S. Karpovich; N. F. Katanov Khakass State University

4. Krasnoyarsk Interdistrict Clinical Hospital of Emergency Care Named after N. S. Karpovich; N. F. Katanov Khakass State University

5. Krasnoyarsk Interdistrict Clinical Hospital of Emergency Care Named after N. S. Karpovich

6. N. F. Katanov Khakass State University

Abstract

The objective: to evaluate the effect of combined use of analgesics, dalargin and tissue metabolism correctors on endocrine-metabolic disorders in patients with thoracoabdominal trauma who were injured in road accidents.Subjects and methods. A single-center prospective randomized study was conducted in 30 victims of road accidents with thoracoabdominal trauma and traumatic shock. In 15 patients of the main group, in addition to conventional therapy, dalargin, lornoxicam were administered intravenously, and remaxol was infused.Results. The combined use of analgesics, dalargin and correctors of tissue metabolism contributed to the maintenance of cortisol concentration at the level of compensated stress in patients of the main group, which indicated more favorable adaptive capabilities of the body.Conclusions. Intensive therapy in patients of the main group helps to reduce the severity of anaerobic processes, optimize energy processes at the cellular level, reduce the enzymatic activity of the liver, and reduces the hospital stay of patients by 5 bed-days.

Publisher

New Terra

Subject

General Materials Science

Reference21 articles.

1. Bagnenko S.F., Polushin Yu.S., Miroshnichenko А.G. et al. Organizatsiya raboty statsionarnogo otdeleniya skoroy meditsinskoy pomoschi: metodicheskie rekomendatsii. [Organization of work in the in-patient emergency care: guideline]. 2nd Edition, reviewed and supplemented, Moscow, GEOTAR-Media Publ., 2018, ‒ 61 с. https://doi.org/10.25016/2541-7487-2020-0-1-05-11.

2. Belyaevskiy А.D., Lebedeva E.А., Kurtasov А.А. et al. Process of adaptation and pathological influence in development of the traumatic illness. Sovremennye Problemy Nauki i Obrazovaniya, 2012, no. 3 (In Russ.) http://science-education.ru/ru/article/view?id=6442 (Accessed: 14.01.2021).

3. Bolshakova M.А., Rakhmanova E.А., Popova E.А. et al. Metod otsenki stepeni tyazhesti postradavshikh v dorozhno-transportnykh proisshestviyakh v dogospitalnom periode, na etape priyemno-diagnosticheskogo otdeleniya gospitalnogo period. [The method for assessing the severity of road accidents victims in the pre-hospital period, admission and diagnostic department of the hospital period]. Patent no. RU 2711384 C1, 16.01.2020. Application no. 2019104825 as of 20.02.2019. https://patenton.ru/patent/RU2711384C1 (Accessed: 14.01.2021).

4. Karamyshev А.M., Ilyukevich G.V. The impact of anesthesia on the endocrine and metabolic component of the stress response during surgical treatment of congenital genitourinary malformations in children. Ekstrennaya Meditsina, 2018, vol. 7, no. 4, pp. 574-583. (In Russ.) https://rucont.ru/efd/602884.

5. Korobova L.S., Lazarev V.V., Balashova L.M. et al. Stress reactions during various anesthesia methods in ophthalmic surgery. Rossiyskiy. Vestnik Detskoy Khirurgii, Anesteziologii I Reanimatologii, 2018, vol. 8, no. 3, pp. 67-75. (In Russ.) https://doi.org/10.30946/2219-4061-2018-8-3-67-75.