Sepsis: source control-Reference-Cited by-同舟云学术

Sepsis: source control

Published:2021-11-06 Issue:5 Volume:18 Page:89-96
ISSN:2541-8653
Container-title:Messenger of ANESTHESIOLOGY AND RESUSCITATION
language:
Short-container-title:Vestn. anesteziol. reanimatol.

Author:

Kulabukhov V. V.¹,Zubareva N. A.²,Yartsev P. A.¹

Affiliation:

1. N. V. Sklifosovsky Research Institute of Emergency Medicine

2. E. A. Vagner Perm State Medical University

Abstract

Sepsis is a life-threatening condition, which is manifested by the development of organ dysfunction due to generalized inﬂammation caused by the infection of various nature. Timely lesion debridement combined with adequate antibiotic therapy are important components of the successful treatment of sepsis. At the moment, there is no consensus about the volume and time of intervention in the development of surgical sepsis. The article discusses modern approaches to solving the problem of adequate sanitation of the source of infection. The results of few randomized trials in this area are presented.Source control is absolutely essential for the successful treatment of sepsis. However, it is difcult to create a unifed algorithm for surgical control for all cases due to diﬀerent approaches depending on the infection location. Properly designed clinical trials are necessary to determine the optimal timing of surgery for sepsis and septic shock as least.

Publisher

New Terra

Subject

Anesthesiology and Pain Medicine,Critical Care and Intensive Care Medicine,Emergency Medicine

Reference49 articles.

1. Аbdominalnaya khirurgicheskaya infektsiya. Rossiyskie natsionalnye rekomendatsii. [Abdominal surgical infection, Russian national guidelines]. 2nd ed., reviewed and supplemented. B.R. Gelfand, А.I. Kirienko, N.N. Khachatryan, eds., Moscow, Meditsinskoye Informatsionnoye Agentstvo Publ., 2018, 168 p.

2. Sepsis: klassifikatsiya, kliniko-diagnosticheskaya kontseptsiya i lecheniye. [Sepsis: classification, clinical and diagnostic concept and treatment]. 4th ed., reviewed and supplemented. B.R. Gelfand, eds., Moscow, OOO MIA-MED Publ., 2017, 408 p.

3. Khirurgicheskiye infektsii kozhi i myagkikh tkaney. Rossiyskiye natsionalnye rekomendatsii. [Surgical skin and soft tissue infections. Russian national guidelines]. B.R. Gelfand, eds., Moscow, OOO Kompaniya Borges Publ., 2015, 115 p.

4. Agor J. K., Paramita N. L. P., Ozaltin O. Y. Prediction of sepsis related mortality: an optimization approac // IEEE J. Biomed. Health Inform. ‒ 2021. ‒ doi: 10.1109/JBHI.2021.3096470.

5. Armstrong B. A., Betzold R. D., May A. K. Sepsis and septic shock strategies // Surg. Clin. North. Am. ‒ 2017. ‒ Vol. 97, № 6. ‒ P. 1339‒1379. doi:10.1016/j.suc.2017.07.003.