Music-elicited EEG Activity and Emotional Responses are Altered in Schizophrenia

Abstract

Studies of patients with schizophrenia using facial affect recognition and voice discrimination tasks have identified emotional dysfunction as a prominent clinical feature. In the present study we examine whether emotion processing in patients is also impaired in a less explicitly social context -- continuous self-report of emotions during music using a two-dimensional (pleasantness X activation) emotion space. Electroencephalographic (EEG) activity was also recorded during this task since previous studies using EEG measures have found underlying cortical processes related to emotion. Twelve patients with schizophrenia and eleven controls listened to five 25-second songs. These songs included J.S. Bach‟s Invention #13 in A minor (BWV 784) (designated the original piece), and four computer-generated pieces of which two were designed to be similar to the original, and two were designed to be different. While no significant effects were found in the activation dimension of the self-report measures, the pattern of pleasantness ratings was significantly less differentiated among songs in the patient group than in controls. EEG asymmetry indices at frontal and central electrodes provided evidence of greater hemispheric activation asymmetry (with higher activation on the left) in controls than in patients, a difference that was significant at the central electrodes (C3 and C4). These findings indicate that individuals with schizophrenia interpret emotion-eliciting music differently than do controls, even in a relatively non-social setting, possibly because of less differentiated hemispheric representations.