Sputum Metabolomic Profiling Reveals Metabolic Pathways and Signatures Associated With Inflammatory Phenotypes in Patients With Asthma

Author:

Liu Ying123ORCID,Zhang Xin123ORCID,Zhang Li123,Oliver Brian G45ORCID,Wang Hong Guang6ORCID,Liu Zhi Peng6,Chen Zhi Hong7ORCID,Wood Lisa8ORCID,Hsu Alan Chen-Yu89ORCID,Xie Min10ORCID,McDonald Vanessa8ORCID,Wan Hua Jing3,Luo Feng Ming23ORCID,Liu Dan2ORCID,Li Wei Min2ORCID,Wang Gang23ORCID

Affiliation:

1. Pneumology Group, Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, PR China.

2. Department of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu, PR China.

3. Laboratory of Pulmonary Immunology and Inflammation, Frontiers Science Center for Disease-related Molecular Network, Sichuan University, Chengdu, PR China.

4. School of Life Sciences, University of Technology Sydney, Ultimo, Australia.

5. Woolcock Institute of Medical Research, The University of Sydney, Sydney, Australia.

6. Biotree-Shanghai, Shanghai, PR China.

7. Shanghai Institute of Respiratory Disease, Respiratory Division of Zhongshan Hospital, Fudan University, Shanghai, PR China.

8. Priority Research Centre for Healthy Lungs, The University of Newcastle, and Hunter Medical Research Institute, Callaghan, Australia.

9. Program in Emerging Infectious Diseases, Duke-National University of Singapore (NUS) Medical School, Singapore.

10. Department of Respiratory and Critical Care Medicine, Tongji Hospital, Huazhong University of Science & Technology, Wuhan, PR China.

Funder

National Natural Science Foundation of China

China Postdoctoral Science Foundation

West China Hospital, Sichuan University

National Key Development Plan for Precision Medicine Research

Publisher

The Korean Academy of Asthma, Allergy and Clinical Immunology and The Korean Academy of Pediatric Al

Subject

Pulmonary and Respiratory Medicine,Immunology,Immunology and Allergy

Reference49 articles.

1. Global Initiative for Asthma. Global strategy for asthma management and prevention [Internet]. place unknown. Global Initiative for Asthma. 2021. cited 2021 Jul. Available from: www.ginasthma.org

2. Inflammatory subtypes in asthma: Assessment and identification using induced sputum

3. Canadian Thoracic Society 2012 Guideline Update: Diagnosis and Management of Asthma in Preschoolers, Children and Adults

4. Lebrikizumab Treatment in Adults with Asthma

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