Surgery for Bowen Disease: Clinicopathological Factors Associated With Incomplete Excision

Author:

Fougelberg JuliaORCID,Ek Hampus,Claeson Magdalena,Paoli JohnORCID

Abstract

Background: One common treatment for Bowen’s disease (BD) is surgical excision, but there is no international consensus on the appropriate surgical margins. Objectives: This study examined what factors affect the rate of incomplete excision of BD. Methods: Clinicopathological data potentially linked to surgical outcome (complete or incomplete excision) were retrospectively collected from medical and histopathological records on all surgically excised BD lesions diagnosed at Sahlgrenska University Hospital in Gothenburg, Sweden during 2014-2015. Data were analyzed with two definitions of incomplete excision: less strict (ie, BD present at the surgical margin) and strict (ie, dysplasia present at the surgical margin). Results: In total, 463 BD lesions among 408 patients were included. With the less strict definition, 3 factors were associated with significantly higher rates of incomplete excision: surgical margins <3 mm, a less experienced surgeon, and use of punch biopsy excision. The same factors plus a tumor location on the head and neck area or upper extremities were associated with significantly higher rates of incomplete excision using the strict definition. After adjustment for confounders, less experience was independently associated with incomplete excision using the less strict definition, whereas less experience and location on the head and neck area or upper extremities were independently associated with incomplete excision using the strict definition. Surgeon specialty was not associated with incomplete excision regardless of the definition. Conclusions: When removing BD surgically, an elliptical excision with surgical margins ≥3 mm carried out by an experienced surgeon should be recommended. Surgical margins may need to be adjusted depending on body site.

Publisher

Mattioli1885

Subject

Dermatology,Genetics,Oncology,Molecular Biology

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Verrucous Bowen\\\'s disease: A case report of an unusual variant;IP Indian Journal of Clinical and Experimental Dermatology;2024-09-15

2. Cryosurgery versus curettage for intraepidermal carcinoma: A randomized controlled trial;Journal of the European Academy of Dermatology and Venereology;2023-07-21

3. Knowledge and awareness about Bowen's disease among dental students;Journal of Advanced Pharmaceutical Technology & Research;2022-11

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