The Role of Ischemia-modified Albumin and Ischemia-modified Albumin to Albumin Ratios in Patients with Alopecia Areata
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Published:2023-01-31
Issue:
Volume:
Page:e2023017
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ISSN:2160-9381
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Container-title:Dermatology Practical & Conceptual
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language:
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Short-container-title:Dermatol Pract Concept
Author:
TanaCan Efsun,Oztekin Aynure,Savcı Unsal,Senel Engin,Oztekin Coskun,Neseoglu Salim,Ozcan Erel
Abstract
Objective: To investigate the role of ischemia-modified albumin (IMA) and IMA/albumin levels in patients with AA.
Methods: The present prospective crossectional study includes patients ≥ 18 who admitted to the Dermatology and Venerology Department of XXXX University Hospital between April 1 2021, and September 30 2021. 70 patients participated in the study (n=34 for the study group and n=36 for the control group). Demographic features, clinical characteristics, IMA, and IMA/albumin levels were compared between the groups. Study group was divided into subgroups based on the number of patches, disease duration, and number of disease attacks. IMA and IMA/albumin levels were compared between each subgroup.
Results: Study and control groups were similar with regard to demographic features and clinical characteristics. Significant differences were observed between the mean IMA and IMA /albumin ratio (p=0.004 and 0.012, respectively). The study subgroups were comparable for the number of patches, disease duration and number of disease attack.
Conclusion: Although oxydative stress is an important component in the etiology of AA, IMA and IMA/albumin may not be useful in the prediction of disease severity in patients with AA.
Keywords: Alopecia areata, ischemia-modified albumin, IMA/albumin, disease severity.
Subject
Dermatology,Genetics,Oncology,Molecular Biology
Cited by
2 articles.
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