The Role of Fallopia baldschuanica Plant Extract in the Regression of Induced Hepatocellular Carcinoma in Rats

Abstract

Liver cancer continues to pose a formidable global health challenge, with its incidence on the rise across the world. Predictions suggest that by 2040, the toll of individuals affected by liver cancer will surpass one million. Consequently, numerous researchers have been motivated to improve therapies and develop new medications with minimal side effects on human health. Plant-derived natural products have offered a variety of pharmacological chemical structures and biologically active substances, which exhibit cytotoxic effects on tumor cells. The current study investigates the potential anti-cancer properties of Fallopia baldschuanica flower extract against thioacetamide (TAA) induced cancer. This study pinpointed specific amino acids in the raw extract, with methionine registering the highest percentage, trailed by cysteine, valine, threonine, tyrosine, isoleucine, and lysine. Amino acids have vital activities in various aspects of human health and the condition of diseases. The aim of this study is to evaluate the potential impact of Fallopia baldschuanica flower extract on the regression of the experimentally induced HCC in rats. These assessments were onducted through the measurement of liver function, involving aspartate aminotransferase, alanine transaminase, and alkaline phosphatase. Moreover, antioxidant enzyme and tumor marker assays were utilized and the histopathological examination to support the findings.