Synthesis and Cholinesterase Inhibitory Activity of Selected Indole-Based Compounds
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Published:2023-12-20
Issue:4
Volume:70
Page:545-559
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ISSN:1580-3155
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Container-title:Acta Chimica Slovenica
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language:
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Short-container-title:ACSi
Author:
Gršič Marija,Meden Anže,Knez Damijan,Jukič Marko,Svete Jurij,Gobec Stanislav,Grošelj Uroš
Abstract
Synthesis and anticholinesterase activity of 18 previously unpublished indole- and tryptophan-derived compounds are disclosed. These compounds containing an indole structural unit exhibit selective submicromolar inhibition of human butyrylcholinesterase (hBChE). The structures of the newly synthesized compounds were confirmed by 1H and 13C NMR, IR spectroscopy, and high-resolution mass spectrometry.
Publisher
Slovenian Chemical Society