Kinetic Studies, Antioxidant Activities, Enzyme Inhibition Properties and Molecular Docking of 1,3-Dihydro-1,3-Dioxoisoindole Derivatives
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Published:2023-03-20
Issue:1
Volume:70
Page:29-43
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ISSN:1580-3155
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Container-title:Acta Chimica Slovenica
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language:
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Short-container-title:ACSi
Author:
Yakan Hasan,Ozturk Seyhan,Tolgay Elvan Uyar,Yenigun Semiha,Marah Sarmad,Doruk Tugrul,Ozen Tevfik,Kutuk Halil
Abstract
The acid catalyzed hydrolysis of the N-(p-substitutedphenyl) phthalimides in three different acids was investigated at 50.0 ± 0.1 °C. Two different antioxidant activity tests as DPPH• and ABTS•+ scavenging activities, and three various enzyme inhibition activity tests as urease, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) inhibition activities, were applied. Compound 3c (2.03 μg/mL ) has higher antioxidant activity than other compounds and standards according to DPPH test. In AChE assay, compounds 3a and 3b (13.13 and 9.59 μg/mL) has higher enzyme inhibition activity than the standard Galantamine (14.37 μg/mL). In BChE and urease tests, all compounds (6.84-13.60 and 10.49-17.73 μg/mL) have higher enzyme inhibition activity than the standard Galantamine (49.40 μg/mL) and thiourea (26.19 μg/mL), respectively. The molecule interaction for each of the three compounds with the active sites of AChE, BChE, and urease enzymes was examined via molecular docking simulations.
Publisher
Slovenian Chemical Society