Association of Genetic Variants With Response to Anti–Vascular Endothelial Growth Factor Therapy in Age-Related Macular Degeneration

Author:

Lorés-Motta Laura1,Riaz Moeen23,Grunin Michelle4,Corominas Jordi15,van Asten Freekje67,Pauper Marc15,Leenders Mathieu1,Richardson Andrea J.2,Muether Philipp8,Cree Angela J.9,Griffiths Helen L.9,Pham Connie10,Belanger Marie-Claude10,Meester-Smoor Magda A.11,Ali Manir12,Heid Iris M.13,Fritsche Lars G.14,Chakravarthy Usha15,Gale Richard16,McKibbin Martin17,Inglehearn Chris F.1217,Schlingemann Reinier O.1819,Omar Amer20,Chen John212223,Koenekoop Robert K.212223,Fauser Sascha824,Guymer Robyn H.2,Hoyng Carel B.1,de Jong Eiko K.1,Lotery Andrew J.9,Mitchell Paul25,den Hollander Anneke I.15,Baird Paul N.2,Chowers Itay4

Affiliation:

1. Department of Ophthalmology, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands

2. Centre for Eye Research Australia, Department of Surgery in Ophthalmology, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia

3. Public Health Genomics, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia

4. Department of Ophthalmology, Hebrew University Hadassah Medical School, Hadassah Medical Center–Hebrew University, Jerusalem, Israel

5. Department of Human Genetics, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands

6. Division of Epidemiology and Clinical Application, National Eye Institute, National Institutes of Health, Bethesda, Maryland

7. Neurobiology, Neurodegeneration, and Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, Maryland

8. Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany

9. Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, England

10. Department Ophthalmology, McGill University Health Centre, Montreal, Québec, Canada

11. Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands

12. Section of Ophthalmology and Neuroscience, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, England

13. Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany

14. Norwegian University of Science and Technology, Trondheim, Norway

15. Queen’s University Belfast, Belfast, Northern Ireland

16. The York Hospital, York, England

17. Eye Clinic, St James’s University Hospital, Leeds, England

18. Department of Ophthalmology, Ocular Angiogenesis Group, Academic Medical Center, Amsterdam, the Netherlands

19. Netherlands Institute for Neuroscience, Amsterdam, the Netherlands

20. Montreal Retina Institute, Westmount, Québec, Canada

21. Department of Pediatric Surgery, McGill University Health Centre, Montreal, Québec, Canada

22. Department of Human Genetics, McGill University Health Centre, Montreal, Québec, Canada

23. Department of Ophthalmology, McGill University Health Centre, Montreal, Québec, Canada

24. Roche Pharma Research and Early Development, Hoffmann–La Roche, Basel, Switzerland

25. Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia

Publisher

American Medical Association (AMA)

Subject

Ophthalmology

Reference63 articles.

1. Prevalence of age-related macular degeneration in the United States.;Friedman;Arch Ophthalmol,2004

2. Global data on visual impairment in the year 2002.;Resnikoff;Bull World Health Organ,2004

3. Prevalence of age-related macular degeneration in Europe: the past and the future.;Colijn;Ophthalmology,2017

4. Age-related macular degeneration and blindness due to neovascular maculopathy.;Ferris;Arch Ophthalmol,1984

5. Ranibizumab for neovascular age-related macular degeneration.;Rosenfeld;N Engl J Med,2006

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