Cost-Utility Comparison of Bevacizumab and Aflibercept in the Treatment of Central or Hemiretinal Vein Occlusion in the SCORE2 Trial-Reference-Cited by-同舟云学术

Cost-Utility Comparison of Bevacizumab and Aflibercept in the Treatment of Central or Hemiretinal Vein Occlusion in the SCORE2 Trial

Published:2023-06-01 Issue:6 Volume:141 Page:554
ISSN:2168-6165
Container-title:JAMA Ophthalmology
language:en
Short-container-title:JAMA Ophthalmol

Author:

Kymes Steven M.¹,Oden Neal L.²,VanVeldhuisen Paul C.²,Scott Ingrid U.³,Ip Michael S.⁴,Blodi Barbara A.⁵,King Jacquie²,Williams George A⁶,Abraham Prema⁶,Bement-Stump Beth⁶,Callahan Leah⁶,Dockter Mindi⁶,Livermont Kristi⁶,Nixon Robert⁶,Parks Dan⁶,Steinle Nathan⁶,Thompson Alison⁶,Yu Dylan⁶,Bailey Steven⁶,Barth Jordan⁶,Blefgen Sara⁶,Campbell J. Peter⁶,Flaxel Christina⁶,Fujisaki Brad⁶,Howell Christopher⁶,Hui Jocelyn⁶,Hwang Thomas⁶,Ira Shirley⁶,Lauer Andreas⁶,Liming Jeanne⁶,Lindblad Phoebe⁶,Lundquist Anne⁶,Mistretta Frank⁶,Nolte Susan⁶,Petrolati Jennifer⁶,Pickell Scott⁶,Ryan Dawn⁶,Schain Mitchell⁶,Steinkamp Peter⁶,Ukachukwu Chiedozie⁶,Berger Adam⁶,Darby Erika⁶,Dilts Vera⁶,Hamilton Richard⁶,Holm Laura⁶,McCarty Tammy⁶,Medina Esmeralda⁶,Misch David⁶,Moon Suk J⁶,Owen Kari⁶,Randolph John⁶,Strickland Jason⁶,Sutherland Dawn⁶,Tolentino Michael⁶,Varner Nicole⁶,Antoszyk Andrew⁶,Balasubramaniam Uma⁶,Bojaj Swann⁶,Browning David⁶,Clark Loraine⁶,Ennis Sarah⁶,Finch Autumn⁶,Fleming Christina⁶,Fredenberg Sherry⁶,Gentile Angie⁶,Jackson Lisa⁶,McClain Donna⁶,McOwen Michael⁶,Price Angela⁶,Punjabi Omar⁶,Rowland Beverly⁶,Watson Lynn⁶,Bloom Ellis⁶,Catapano Thomas⁶,Chornobai Mariia⁶,Hollimon Nicole⁶,Hu Allen⁶,King Donna⁶,McChancy Christa⁶,McCullough Wendy⁶,Miller Kristen⁶,Sanborn George⁶,Sesay Ejiatu⁶,Shetler Veronica⁶,Smith Paula⁶,Varner Becca⁶,Wallech Leslee⁶,Ward Shayla⁶,Warrow David⁶,Wenger Cherie⁶,Wentz Alison⁶,Wood Kimberly⁶,Wroblewski John⁶,Almeida Shannon⁶,Bergman Vanessa⁶,Booth Joann⁶,Bradford Reagan⁶,Brewer Alisha⁶,Burris Russ⁶,Butt Mandi⁶,Drummond Vanessa⁶,Fransen Stephen⁶,Icks Sonny⁶,Kingsley Ronald⁶,Leonard Robert⁶,Miller Heather⁶,Shah Vinay⁶,Wolzen Vicki⁶,Bayer Krista⁶,Eggert Lorraine⁶,Geraghty Susan⁶,Harper Morgan⁶,Ie Darmakusuma⁶,Knezek Lauren⁶,Lipkowitz Jeffrey⁶,Sannazzaro Beverly⁶,Shah Kekul⁶,Sadda Srinivas R⁶,Balakrishnan Renjini⁶,Bano Fazilla⁶,Brinton Daniel⁶,Bustamante Denise⁶,Casugay Elyssa⁶,Casupanan Roby⁶,Chung Patty⁶,Enyart Heather⁶,Frambach Caroline⁶,Jackson Khaliah⁶,Jamali Afsoon⁶,Kwan Mae⁶,Lee Scott⁶,Lit Eugene⁶,Machacon Joshua⁶,Madrigal Patty⁶,Renslow Scotty⁶,Ricks Helen⁶,Rofagha Soraya⁶,Winje Heidi⁶,Belz Jennifer⁶,Cain Theresa⁶,Coffey Teresa⁶,Davis Ashley⁶,Elman Michael⁶,Leder Henry⁶,Metzger Ashley⁶,Orr Peggy⁶,Sandler Dallas⁶,Simmons Jennifer⁶,Simpson Perel⁶,Singletary Pamela⁶,Sotirakos Peter⁶,Starr JoAnn⁶,Thompson Amy⁶,Brower Judy⁶,Cribbs Blaine⁶,Curtis Linda⁶,Dobbs Jannah⁶,Gibbs Deborah⁶,Hendrick Andrew⁶,Hubbard G. Baker⁶,Jordan Debbie⁶,Leef Donna⁶,Middleton Darien⁶,O'Keefe Ghazala⁶,Olson Timothy⁶,Pearson Samillya⁶,Raeber Matthew⁶,Robinson Joshua⁶,Rogers Susan⁶,Yan Jiong⁶,Andrews Jackie⁶,Carlton Steve⁶,Dawson Katrina⁶,Fagan Damanda⁶,Friedman Scott⁶,Marsh Tammi⁶,McKinney Allen⁶,Moinfar Nader⁶,Seyez Karen⁶,Walters Paige⁶,Wendel Ceara⁶,Williamson Kimberly⁶,Domalpally Amitha⁶,Reed Susan⁶,Vargo Pamela⁶,Jones Jini⁶,Jones Leslie⁶,Lampert Scott⁶,Marcus Leslie⁶,Mukkamala Krishna⁶,Neal Lindsey⁶,Nunn Lauren⁶,Rogers Maria⁶,Sharma Atul⁶,Stoltz Robert⁶,West Morgan⁶,Allis Megan⁶,Benvenutti Celia⁶,Burley David⁶,Desai Uday⁶,Edwards Paul⁶,Gao Hua⁶,Grybas John⁶,Gutkowski Melanie⁶,Hall Julianne⁶,Hessburg Thomas⁶,Kumar Nitin⁶,Massu Nicole⁶,Mazurek Melina⁶,Monk Mary⁶,Murphy Janet⁶,Nelson Jessica⁶,Oude-Reimerink Dina⁶,Rusinek Brian⁶,Shaheen Jenny⁶,Staffne Jessica⁶,Stern Bradley⁶,Troszak Tracey⁶,Ventimiglia Katie⁶,Carrasquillo-Boyd Wanda⁶,Chui Yuen Ping⁶,Gentile Ronald⁶,Mehta Priya⁶,Rivas Melissa⁶,Rosen Richard⁶,Soo Choi John Bo⁶,Tai Katy⁶,Tan Jia⁶,Unson Meliza⁶,Whitten Paul⁶,Yang Alex⁶,Carroll Catherine⁶,Chau Felix⁶,Janowicz Mark⁶,Johnson Tametha⁶,Leiderman Yannek⁶,Lim Jennifer⁶,Niec Marcia⁶,Ovando Yesenia⁶,Reyes Kevin⁶,Stankovic Natasa⁶,Sun Jie⁶,Talasnik Lauren⁶,Ulanski Lawrence⁶,Reed Cynthia⁶,Assissini Armand⁶,Cerdenio Marvyn⁶,Fan Joseph⁶,Hernandez Raquel⁶,Huang Lynn⁶,Kiernan William⁶,Knabb Jesse⁶,Rauser Michael⁶,Santiago Gisela⁶,Suthar Mukesh⁶,Williams Brandon⁶,Chitjian Michael⁶,DAmore Kristen⁶,Deramo Vincent⁶,Fastenberg David⁶,Ferrone Philip⁶,Golub Barry⁶,Graham Kenneth⁶,Jaya Sandra⁶,Jonisch Jonathan⁶,Rhee David⁶,Romero Juan⁶,Rosenblatt Brett⁶,Schlameuss Marianne⁶,Shakin Jeffrey⁶,Shakin Eric⁶,Sookhai Vasanti⁶,Szczepanski Jamie⁶,Baker Betsy⁶,Bakri Sophie⁶,Barkmeier Andrew⁶,Burrington Jean⁶,Currie Gillian⁶,Franzen Melissa⁶,Goddard Shannon⁶,Lewison Denise⁶,Morgan Jessica⁶,Nielsen Rebecca⁶,Overend Joan⁶,Rubin Heidi⁶,Smith Wendy⁶,Tesmer Jamie⁶,Thatcher Stephanie⁶,Vogen Diane⁶,Bell Darren⁶,Bolado Carrisa⁶,Burns Jason⁶,Dominguez Melissa⁶,Ellis Catherine⁶,Escobar Rosa⁶,Evans Richard⁶,Goel Shelli⁶,Gomez Roxanne⁶,Huron Felicia⁶,Montoya Guillermo⁶,Myrick Cynthia⁶,Rittimann Judy⁶,Segovia Vincent⁶,Singer Michael⁶,Barwick Vicki⁶,Beringer Joe⁶,Carroll Joseph⁶,Connor Thomas⁶,Dorsey Eleanor⁶,Goldberg Mara⁶,Han Dennis P⁶,Keller Kristy⁶,Kim Judy⁶,McKenney Katie⁶,Moebius Stephanie⁶,Packard Krissa⁶,Stepien Kimberly⁶,Weinberg David⁶,Williams Vesper⁶,Winter Pat⁶,Wirostko William⁶,Benfield Hannah⁶,Centinaro Christina⁶,Chiang Allen⁶,Devine Lauren⁶,Fineman Mitchell⁶,Formoso Michele⁶,Garg Sunir⁶,George Cedric⁶,Gonzales Elaine⁶,Grande Lisa⁶,Gupta Omesh⁶,Ho Allen⁶,Houston Samuel⁶,Hsu Jason⁶,Jay Maryann⁶,Kaiser Richard⁶,Kenney Brianna⁶,Lavetsky Lisa⁶,Listner Theresa⁶,Maguire Joseph⁶,Mehta Sonia⁶,Noble Jill⁶,Park Carl⁶,Rahimy Ehsan⁶,Reed David⁶,Regillo Carl⁶,Senderowitsch Noga⁶,Sivalingam Arunan⁶,Spirn Marc⁶,Sudler Jamilla⁶,Ciulla Thomas⁶,Dale Tammy⁶,Finnen Neil⁶,Harris Charlotte⁶,Hood Cindi⁶,Kerr Ingrid⁶,Maturi Raj⁶,Phillips Kristin⁶,Radtke Ashley⁶,Robson Shyla⁶,Sink Bethany⁶,Steele Tom⁶,Ghuman A. Thomas⁶,Greenhoe Laura⁶,Kiesel Cheryl⁶,Kiesel Ray⁶,Knips Eileen⁶,Leslie Anita⁶,Maro Kristi⁶,Peters Crystal⁶,Raskauskas Paul⁶,Ryan Cheryl⁶,Saez Jessica Lynn⁶,Sharma Ashish⁶,Torres (Crawford) Natalie⁶,Turnbo Danielle⁶,Walker Joseph⁶,Wing Glenn⁶,Berezina Tamara⁶,Bhagat Neelakshi⁶,Boschert Kathryn⁶,Buroff Eileen⁶,Ellenberger Janie⁶,Fay Catherine⁶,Konop Marian⁶,Lazar Michael⁶,Mikheyeva Tatiana⁶,Roy Monique⁶,Zarbin Marco⁶,Bhargava Sangeeta⁶,Fine Howard⁶,Fox Gadless Laura⁶,Friedman Eric⁶,Green Stuart⁶,Green Robyn⁶,Keyser Bruce⁶,Leviton Amy⁶,Nelson Celeste⁶,Pilato Jennifer⁶,Prenner Jonathan⁶,Roth Daniel⁶,Schlosser Alex⁶,Shah Sumit⁶,Wheatley H. Matthew⁶,Yarian David⁶,Bansal Alok⁶,Boldrey Edwin⁶,Borrillo Jesus⁶,Chang Louis⁶,Dennis Amy⁶,Depaz Sharon⁶,Gadda Andrea⁶,Goldstein Amy⁶,Khurana Rahul⁶,Lam Diana⁶,Obando Celeste⁶,Palmer James⁶,Sessions Olga⁶,Wieland Mark⁶,Ambrocio Trisha⁶,Casiano Marinel⁶,Chang Eugene⁶,Chen Sanford⁶,Liu Millie⁶,Lowery Jessica⁶,Maggiano John⁶,Rathod Rajiv⁶,You Timothy⁶,Baker Carl⁶,Caldwell Tracey⁶,Camp Alecia⁶,Kettler Samantha⁶,Lambert Lynnette⁶,Martin Tracey⁶,Orr Margaret⁶,Palmer Mary Jill⁶,Tilford Ron⁶,Williams Tana⁶,Bearden Ruth⁶,Clark Lloyd⁶,Darlington Pamela⁶,Griggs Rene⁶,Johnson David⁶,Karuza Stephanie⁶,Miller Peggy⁶,Ogbuewu Tiffany⁶,Payne John⁶,Spivey Robin⁶,Studebaker Ashley⁶,Swinford Tiffany⁶,Taylor Mallie⁶,Watts Deborah⁶,Wells John⁶,Wilson Amanda⁶,Clark W. Lloyd⁶,Floyd Ashley⁶,Garrison Cassandra⁶,Huggins Tyler⁶,Parker Crystal⁶,Poston Erin⁶,Welch Kristin⁶,Williams Ashley⁶,Gaston Janelle⁶,Abdelgani Diana⁶,Blank Colin⁶,Chang Emmanuel⁶,Fredrickson Deborah⁶,Khawly Joseph⁶,Lopez Desiree⁶,Lowd Donald⁶,Martinez Lorena⁶,Miller Pam⁶,Muniz Jason⁶,Pineda Erica⁶,Rahman Hassan⁶,Willis Arthur⁶,Batlle Ivan⁶,Batlle Karla⁶,Bruce Kiersten⁶,Christensen Ryan⁶,Cooper Blake⁶,Dyer David⁶,Fox Gregory⁶,Manning Lexie⁶,Perkins Samantha⁶,Pippin Katherine⁶,Singh Ravi⁶,Suiter Beatty⁶,Yeager Frank⁶,Amonett Brett⁶,Boehm Cindy⁶,Coney Joseph⁶,Coyne Jim⁶,Drugan Tia⁶,DuBois John⁶,Greanoff Gregg⁶,Ilc Mary⁶,Kenska Aimee⁶,McNamara Elizabeth⁶,Miller David⁶,Novak Michael⁶,Rao Llewelyn⁶,Rath Susan⁶,Rykena Cecelia⁶,Schartman Jerome⁶,Singerman Lawrence⁶,Smith Veronica⁶,Tanner Vivian⁶,Buck Michelle⁶,Daniels Vernie⁶,Holcomb Diana⁶,Isernhagen Ricky⁶,Kitchens John⁶,Moshfeghi Andrew⁶,Slade Ed⁶,Stone Thomas⁶,Van Arsdall Jeanne⁶,VanHoose Brenda⁶,Wood William⁶,Burgess Mindy⁶,Connolly Brian⁶,Doran Mary Jo⁶,Guillet Ernest⁶,Hall Edward⁶,Reynard Anne⁶,Rose Steven⁶,Territo Joseph⁶,Whelehan Margaret⁶,Yagoda Meg⁶,Bachmann Dyonne⁶,Brandon Sally⁶,Burdick Kassandra⁶,Carreon Jennifer⁶,Duncan Crystal⁶,Flores Susana⁶,Halper Stacey⁶,Hudson Henry⁶,Kan Amy⁶,Kurup Shree⁶,Mendoza Claudia⁶,Morris Brianna⁶,Novalis George⁶,Wilkins Patricia⁶,Wong Ryan⁶,Worrall Martin⁶,Almanza Belinda⁶,Benz Matthew⁶,Berry Meredith⁶,Brown David⁶,Carranza JoLene⁶,Chen Eric⁶,Dives Brenda⁶,Epp Lauren⁶,Fish Richard⁶,Franks Nikki⁶,Gillaspia Debbie⁶,Hernandez Amy⁶,Kegley Eric⁶,Kim Rosa⁶,Landaverde Nubia⁶,Major James⁶,Quellar Elizabeth⁶,Richter Beau⁶,Royse Tressa⁶,Schefler Amy⁶,Smith Robert⁶,Sneed Veronica⁶,Stoever Cary⁶,Vance Sushma⁶,Wong Tien⁶,Wykoff Charles⁶,Anderson Kelly⁶,Arambula Thomas⁶,Fabro Jennie⁶,Galura Joe⁶,Garcia Nikki⁶,Gomes Leide⁶,Henry Marcy⁶,Hollifield Rodney⁶,Loo Roy⁶,Marchese Janet⁶,Okeke Ifeyinwa⁶,Pezda Matthew⁶,Rendorio Javier⁶,Spencer Treseelyn⁶,Thach Allen⁶,Voo Irene⁶,Wickens Jason⁶,Yepremyan Meher⁶,Anagnoste Scott⁶,Brady-Pyka Jaclyn⁶,del Cid Mario⁶,Dhalla Mandeep⁶,Halperin Lawrence⁶,Hamlin Monica⁶,Lamb Ann Marie⁶,Mannarelli Angelia⁶,Mariano Jamie⁶,O'Koren Linda⁶,Rosenberg Krista⁶,Taney Barry⁶,Thompson W. Scott⁶,Uchiyama Eduardo⁶,Veksler Rita⁶,Casey Heather⁶,Chaudhry Nauman⁶,Cocilo Justin⁶,Fontecchio Alison⁶,German Emma⁶,Charpentier Peggy⁶,Connaughton Michele⁶,Dreyer Richard⁶,Ho Stephanie⁶,Hobbs Stephen⁶,Hoerner Christine⁶,Kopfer Marcia⁶,Lee Michael⁶,Logan Joseph⁶,Ma Colin⁶,Milliron Amanda⁶,Patel Apurva⁶,Peters Mark⁶,Tlucek Paul⁶,Adams Leah⁶,Escamilla Cecilia⁶,Espinoza Geneva⁶,Garcia Kristen⁶,Janzen Grant⁶,Lee Seong⁶,Moreno Priscilla⁶,Patel Sunil⁶,Petty Cindy⁶,Rickert Gary⁶,Villarreal Deisy⁶,Zavaleta Eric⁶,Bergren Robert⁶,Chamberlin Jennifer⁶,Conrad Paul⁶,DiPerna Dawn⁶,Doft Bernard⁶,Eadie James⁶,Fec Amanda⁶,Grossman Moryssa⁶,McBroom Keith⁶,Merlotti Lori⁶,Olsen Karl⁶,Rath Pamela⁶,Schultz Christina⁶,Steinberg David⁶,Stepansky Lois⁶,Vyas Avni⁶,Walter Julie⁶,Bellows Brandi⁶,Brown Jamin⁶,Deforge Teresa⁶,DeSantis Stefanie⁶,Dorr Christine⁶,Gabris Viki⁶,Grinnell Cindy⁶,Hall Christy⁶,Hampton G. Robert⁶,Hay Peter⁶,Kwasniewski Lynn⁶,Manley Michelle⁶,Robarge Nicole⁶,Rosenberg Kevin⁶,Seth Rajeev⁶,Sienkiewycz Laurie⁶,Clark Kim⁶,Foxman Brett⁶,Foxman Scott⁶,Mahan Natalie⁶,Margolis Thomas⁶,Mendez Chastity⁶,Morales Felisha⁶,Morales Suzie x⁶,Rosenthal Julie⁶,Torres Qahdirah⁶,Chang Margaret⁶,Equi Robert⁶,Lopez Danny⁶,Nickerman Erin⁶,Patel Arun⁶,Pearlman Joel⁶,Podesta Nanette⁶,Reed J. Brian⁶,Telander David⁶,Tsai Tony⁶,Waller Brooke⁶,Wendel Robert⁶,Wong Kimberlee⁶,Arenas Sandra⁶,Barakat Mark⁶,Bartoli Dayna⁶,Dugel Pravin⁶,Goldenberg David⁶,Haak L. Milad⁶,Hoback Valerie⁶,Itty Sujit⁶,Jamal Karim⁶,Jimenez Norma⁶,Kunimoto Derek⁶,Levison Ashleigh⁶,Lopez-Wood Georgina⁶,Marcos Elena⁶,Martin John⁶,Mehta Sachin⁶,Palejwala Neal⁶,Quinlan Edward⁶,Ramirez Nohemi⁶,Torres Ignacio⁶,Wilson Diania Joy⁶,Baker Jaynee⁶,Castillo Elaine⁶,Chica Moises⁶,Holy Sarah⁶,Kirschbaum Lita⁶,Lane Richard Gary⁶,Mein Calvin⁶,Moore Tori⁶,Nakoski Brenda⁶,Wienecke C. Sean⁶,Burge Kelli⁶,Cassell Michael⁶,Chen Yin⁶,Elliott Heather⁶,Gallimore Gary⁶,Kietzman Kristen⁶,Kunjukunju Nancy⁶,Niblock Jeanne⁶,Poulose Abraham⁶,Sabates Nelson⁶,Sabates Felix⁶,Snider April⁶,Chen Melvin⁶,Inlow Evelyn⁶,Jelemensky Peggy⁶,Levy Marc⁶,Miller Rosa⁶,Raphael Tara⁶,Sneath Mark⁶,Berger Jim⁶,Brucker Alexander⁶,Caggiano Dominique⁶,Chen Judy⁶,Drossner Sheri⁶,DuPont Joan⁶,Farazdaghi Armin⁶,Kim Benjamin⁶,Morales Sara⁶,Serpentine Beth⁶,VanderBeek Brian⁶,Bailey Thomas⁶,Farooq Amina⁶,Foster Allison⁶,Ivey Ken⁶,Marcus Dennis⁶,Ortiz Siobhan⁶,Singh Harinderjit⁶,Tuey Kim⁶,Woodward Michele⁶,Coppola Patricia⁶,Googe Joseph⁶,Lince Raul⁶,Lovelady Lisa⁶,McMillan Tod⁶,Morris Steve⁶,Oelrich Sarah⁶,Oliver Kristina⁶,Rauen Julie⁶,Shuler R. Keith⁶,Walsh Justin⁶,Whetstone Jerry⁶,Chan Clement⁶,Gonzales Tiana⁶,Huff Kenneth⁶,Lalezary Maziar⁶,Lin Steven⁶,Myers Lenise⁶,Walther Kim⁶,Arrindell Everton⁶,Awh Carl⁶,Bowers Michelle⁶,Briley Amanda⁶,Busbee Brandon⁶,Campbell Talisha⁶,Cooper Narey⁶,Farmer Tara⁶,Ferrell Amanda⁶,Fleischman Casi⁶,Freeman Paul (Dustin)⁶,Hines Sarah⁶,Moffat Kenneth⁶,Morrow Stephanie⁶,Recchia Franco⁶,Reichstein David⁶,Rose Kris⁶,Schneider Eric⁶,Schwebel Natalie⁶,Scott Shari⁶,Smith Gina⁶,Sonkin Peter⁶,Sonnier Cora⁶,Stepney Kyra⁶,Thompson Katlyne⁶,Walker Caleb⁶,Wallace R. Trent⁶,Wiser Susan⁶,Wray Julia⁶,Alva Melissa⁶,Boleman Bob⁶,Callanan David⁶,Creighton Jodi⁶,Curry Michelle⁶,Dock Chris⁶,Lash Sandy⁶,Solley Wayne⁶,Williams Patrick⁶,Anand Rajiv⁶,Arceneaux Sally⁶,Carpintero Daniel⁶,Chong Deborah⁶,Coors Lori⁶,Csaky Karl⁶,Duignan Karen⁶,Fish Gary⁶,Fuller Dwain⁶,Hesse Nick⁶,Jaramillo Diana⁶,Mackens Michael⁶,Marin Samantha⁶,Sanchez Brenda⁶,Stanley Tina⁶,Wang Robert⁶,Bradley Lena⁶,De Stefano Jodi⁶,Figueroa Maria J⁶,Guan Eileen⁶,Hoehn Anne⁶,Irazabal Alexa⁶,Isman Susan⁶,King Jacquie⁶,Kondapaka Radhika⁶,Kumar Hamsa⁶,Lahut Matt⁶,Lindblad Robert⁶,Lovett Robin⁶,Patschak Michael⁶,Rothwell Ro Shauna⁶,Smith Rosemary⁶,Van Dyke Janet⁶,Watson Valerie⁶,Yesko Lauren⁶,Bloom William⁶,Fish PJ⁶,Letson Alan⁶,Mihalik Barbara⁶,Ohr Matthew⁶,Perry Jerilyn⁶,Salerno Jill⁶,Alexander-Snowden Tanya⁶,Alou Sekou⁶,Berinstein Daniel⁶,Blondo Thomas⁶,Camia Jennifer⁶,Chancey Ashley⁶,Clark Clete⁶,Davis Justin⁶,Deegan William⁶,Denny Vanessa⁶,Fanous Irene⁶,Gallerson Bryan⁶,Garfinkel Richard⁶,Gopakumar Smitha⁶,Hanselman Sarah⁶,Iglesias Jessica⁶,Iraheta Yury⁶,Johnson Thomas⁶,Kalisch Molly⁶,King Andrew⁶,Lai Michael⁶,Marin-Quinones Myradis⁶,Melamud Alexander⁶,Murphy Bryan⁶,Murphy Robert⁶,Orencia Stacie⁶,Osman Michael⁶,Phosaksee Jennifer⁶,Rauch Steve⁶,Reilly Gayatri⁶,Renteria Pamela⁶,Rivers Michael⁶,Sanders Reginald⁶,Schorer Nicole⁶,Shah Mona⁶,Shah Manali⁶,Talatory Maya⁶,Tam Tiffany⁶,von Fricken Manfred⁶,Walker Danielle⁶,Blinder Kevin⁶,Boyd Lynda⁶,Guevara Stephanie⁶,Hoehn Erika⁶,Nobel Ginny⁶,Pepple Kelly⁶,Pulliam Brooke⁶,Reardon Diana⁶,Shah Gaurav⁶,Smith Bradley⁶,Stuart Maria⁶,Weeks Rhonda⁶,Wehmeier Jarrod⁶,Wright Tim⁶,Berger Brian⁶,Bravenec Chelsey⁶,Chexal Saradha⁶,Corak Boris⁶,Gunderson Ivana⁶,Hosein Kimberly⁶,Jhaveri Chirag⁶,Manhart Ginger⁶,Nguyen Brandon⁶,Reid Ryan⁶,Ren Yong⁶,Seidu Tina⁶,Stovall Chandler⁶,Ballard Kristi⁶,Blaisdell Ashley⁶,Clay April⁶,Fuentes Shellie⁶,Gillispie Stephanie⁶,Gordon Carmelina⁶,Hill Heather⁶,Litzer Hailey⁶,Lok Elaine⁶,Minier Bonnie⁶,Partridge Susan⁶,Westgate Tiffany⁶,Wireman Jennifer⁶,Wohlscheid Celia⁶,Andrada Marie⁶,Bryant Ashley⁶,Cargill Dominique⁶,Chandra Karishma⁶,Deo Sashi⁶,Imson Katrina⁶,Morse Lawrence⁶,Moshiri Ala⁶,Park Susanna⁶,Redenbo Ellen⁶,Salvador Marisa⁶,Sarwary Nadir⁶,Slabosnitskiy Igor⁶,Trovitch Peter⁶,Turner Jessica⁶,Wallace Cindy⁶,Duncan Jacque⁶,Eubank Don⁶,Fields Scott⁶,Hom Betty⁶,Lew Mary⁶,Light Andrew⁶,Mian Arshia⁶,Stewart Jay⁶,Chalam Kakarla⁶,Cowart Ashley⁶,Grover Sandeep⁶,Gupta Shailesh⁶,Haji Shamim⁶,Hamdani Ghulam⁶,Hart Sherri⁶,Sambhav Kumar⁶,Aprelkov Miroslava⁶,Blackburn Peter⁶,Fraser Claire⁶,Hanson Mike⁶,Higgins Eric⁶,Kleinman Mark⁶,McDonald Deborah⁶,Pearson P. Andrew⁶,Phillips Susan⁶,Pigulko Lyudmila⁶,Reg Michele⁶,Sitzlar Stephen⁶,Smith Lakisha⁶,Musch David C⁶,Wisniewski Stephen⁶,Chung Mina⁶,Czubinski Andrea⁶,DiLoreto David⁶,Forbes Tanya⁶,Gagarinas Gary⁶,Hollar Rachel⁶,Latchney Lisa⁶,Pannell Taylor⁶,Richardson Brittany⁶,Adler Angie⁶,Altaweel Michael⁶,Blodi Barbara⁶,Dietzman Kristine⁶,Gottlieb Justin⁶,Ip Michael⁶,Krolnik Denise⁶,Perry-Raymond Jennie⁶,Peterson John⁶,Reed Sandie⁶,Smith Christopher⁶,Berg Lola⁶,Blaiotta Maria⁶,Do Diana⁶,Greer Lisa⁶,Jawed Fayez⁶,Miller Kristi⁶,Neely Donna⁶,Nguyen Quan⁶,Clifton Brad⁶,Ernst Patricia⁶,Jones Ron⁶,Kinyoun James⁶,Kyle Soojin⁶,Leslie Jim⁶,Pettingill Juli⁶,Purcell Jeffrey⁶,Rath Sue⁶,Rezaei Kasra⁶,Vemulakonda Gurunadh⁶,Vo Bao-Chau⁶,Adyanthaya Rohit⁶,Aguero Lazaro⁶,Anaya Deyla⁶,Cantu Monica⁶,Diaz-Rohena Roberto⁶,Garza Santos⁶,Gonzalez Victor⁶,Jasso Hector⁶,Miranda Karina⁶,Muniz Jessica⁶,Patel Nehal⁶,Rodriguez Rachel⁶,Rodriguez Jessica⁶,Salinas Yesenia⁶,Salinas Nancy⁶,Salinas Kethsaly⁶,Santiago Juan⁶,Villanueva Lissete⁶,Adkins Tony⁶,Agarwal Anita⁶,Brantley Milam⁶,Carlson Joshua⁶,Cherney Edward⁶,Daniels Anthony⁶,Jonna Gowtham⁶,Kim Stephen⁶,Law Janice⁶,Munn Rocky⁶,Owings Sandy⁶,Patel Shriji⁶,Ruark Scott⁶,Skellie Richard⁶,Sternberg Paul⁶,Taylor-Ward Maryann⁶,Anderlini Lea⁶,Bartlett Mark⁶,Combs James⁶,Ebert Eleanore⁶,Hughes Michael⁶,Ladd Byron⁶,McKeever Kristin⁶,Roderick Lynn⁶,Sullivan Karen⁶,Vaughan Melissa⁶,Barloon A. Samuel⁶,Birnbach Charles⁶,Blustein Andrea⁶,Francis Robert⁶,Gagnon Renee⁶,Goldman Pamela⁶,Hunt Ray⁶,Kipp Frances⁶,Klesert Todd⁶,Minnis DeShawn⁶,Nash Robert⁶,Nazarchuk Tetyana⁶,Saperstein David⁶,Wells Craig⁶,Bennett Steven⁶,Bogolin Tamra⁶,Chan-Tram Carmen⁶,Cheshier Holly⁶,Davies John⁶,Dev Sundeep⁶,Enloe Julianne⁶,Gilbert Peggy⁶,Gromov Timothy⁶,Johnson Jill⁶,Jones Tori⁶,Mittra Robert⁶,Oestreich Neal⁶,Parke D. Wilkin⁶,Quiram Polly⁶,Ramsay Robert⁶,Rogers Carol⁶,Royle Joy⁶,Steele Trenise⁶,Tonsfeldt Jessica⁶,Williams David⁶,

Affiliation:

1. The Medwin Group, St Louis, Missouri

2. The Emmes Company, Rockville, Maryland

3. Penn State College of Medicine, Hershey, Pennsylvania

4. Doheny Eye Institute, University of California, Los Angeles

5. Wisconsin Reading Center, University of Wisconsin, Madison

6. for the SCORE2 Investigator Group

Abstract

ImportanceRetinal vein occlusion is the second most common retinal vascular disease. Bevacizumab was demonstrated in the Study of Comparative Treatments for Retinal Vein Occlusion 2 (SCORE2) to be noninferior to aflibercept with respect to visual acuity in study participants with macular edema due to central retinal vein occlusion (CRVO) or hemiretinal vein occlusion (HRVO) following 6 months of therapy. In this study, the cost-utility of bevacizumab vs aflibercept for treatment of CRVO is evaluated.ObjectiveTo investigate the relative cost-effectiveness of bevacizumab vs aflibercept for treatment of macular edema associated with CRVO or HRVO.Design, Setting, and ParticipantsThis economic evaluation study used a microsimulation cohort of patients with clinical and demographic characteristics similar to those of SCORE2 participants and a Markov process. Parameters were estimated and validated using a split-sample approach of the SCORE2 population. The simulated cohort included 5000 patients who were evaluated 100 times, each with a different set of characteristics randomly selected based on the SCORE2 trial. SCORE2 data were collected from September 2014 October 2019, and data were analyzed from October 2019 to July 2021.InterventionsBevacizumab (followed by aflibercept among patients with a protocol-defined poor or marginal response to bevacizumab at month 6) vs aflibercept (followed by a dexamethasone implant among patients with a protocol-defined poor or marginal response to aflibercept at month 6).Main Outcomes and MeasuresIncremental cost-utility ratio.ResultsThe simulation demonstrated that patients treated with aflibercept will have an expected cost $18 127 greater than those treated with bevacizumab in the year following initiation. When coupled with the lack of clinical superiority over bevacizumab (ie, patients treated with bevacizumab had a gain over aflibercept in visual acuity letter score of 4 in the treated eye and 2 in the fellow eye), these results demonstrate that first-line treatment with bevacizumab dominated aflibercept in the simulated cohort of SCORE2 participants. At current price levels, aflibercept would be considered the preferred cost-effective option only if treatment restored the patient to nearly perfect health.Conclusions and RelevanceWhile there will be some patients with CRVO-associated or HRVO-associated macular edema who will benefit from first-line treatment with aflibercept rather than bevacizumab, given the minimal differences in visual acuity outcomes and large cost differences for bevacizumab vs aflibercept, first-line treatment with bevacizumab is cost-effective for this condition.

Publisher

American Medical Association (AMA)

Subject

Ophthalmology

Link

https://jamanetwork.com/journals/jamaophthalmology/articlepdf/2804743/jamaophthalmology_kymes_2023_oi_230019_1686235832.44922.pdf

Reference19 articles.

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4. Effect of bevacizumab vs aflibercept on visual acuity among patients with macular edema due to central retinal vein occlusion: the SCORE2 randomized clinical trial.;Scott;JAMA,2017

5. Consolidated Health Economic Evaluation Reporting Standards 2022 (CHEERS 2022) statement: updated reporting guidance for health economic evaluations.;Husereau;BMJ,2022

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