Contrasting Characteristics and Outcomes of Sports-Related and Non–Sports-Related Traumatic Brain Injury-Reference-Cited by-同舟云学术

Contrasting Characteristics and Outcomes of Sports-Related and Non–Sports-Related Traumatic Brain Injury

Published:2024-01-24 Issue:1 Volume:7 Page:e2353318
ISSN:2574-3805
Container-title:JAMA Network Open
language:en
Short-container-title:JAMA Netw Open

Author:

Ntikas Michail¹,Stewart William²,Ietswaart Magdalena¹,Hunter Angus M.³,Maas Andrew I. R.⁴,Menon David K.⁵,Wilson Lindsay¹, ,Ackerlund Cecilia⁶,Amrein Krisztina⁶,Andelic Nada⁶,Andreassen Lasse⁶,Anke Audny⁶,Antoni Anna⁶,Audibert Gérard⁶,Azouvi Philippe⁶,Azzolini Maria Luisa⁶,Bartels Ronald⁶,Barzó Pál⁶,Beauvais Romuald⁶,Beer Ronny⁶,Bellander Bo-Michael⁶,Belli Antonio⁶,Benali Habib⁶,Berardino Maurizio⁶,Beretta Luigi⁶,Blaabjerg Morten⁶,Bragge Peter⁶,Brazinova Alexandra⁶,Brinck Vibeke⁶,Brooker Joanne⁶,Brorsson Camilla⁶,Buki Andras⁶,Bullinger Monika⁶,Cabeleira Manuel⁶,Caccioppola Alessio⁶,Calappi Emiliana⁶,Calvi Maria Rosa⁶,Cameron Peter⁶,Carbayo Lozano Guillermo⁶,Carbonara Marco⁶,Castaño-León Ana M.⁶,Cavallo Simona⁶,Chevallard Giorgio⁶,Chieregato Arturo⁶,Citerio Giuseppe⁶,Clusmann Hans⁶,Coburn Mark Steven⁶,Coles Jonathan⁶,Cooper Jamie D.⁶,Correia Marta⁶,Čović Amra⁶,Curry Nicola⁶,Czeiter Endre⁶,Czosnyka Marek⁶,Dahyot-Fizelier Claire⁶,Dark Paul⁶,Dawes Helen⁶,De Keyser Véronique⁶,Degos Vincent⁶,Della Corte Francesco⁶,den Boogert Hugo⁶,Depreitere Bart⁶,Đilvesi Đula⁶,Dixit Abhishek⁶,Donoghue Emma⁶,Dreier Jens⁶,Dulière Guy-Loup⁶,Ercole Ari⁶,Esser Patrick⁶,Ezer Erzsébet⁶,Fabricius Martin⁶,Feigin Valery L.⁶,Foks Kelly⁶,Frisvold Shirin⁶,Furmanov Alex⁶,Gagliardo Pablo⁶,Galanaud Damien⁶,Gantner Dashiell⁶,Gao Guoyi⁶,George Pradeep⁶,Ghuysen Alexandre⁶,Giga Lelde⁶,Glocker Ben⁶,Golubović Jagoš⁶,Gomez Pedro A.⁶,Gratz Johannes⁶,Gravesteijn Benjamin⁶,Grossi Francesca⁶,Gruen Russell L.⁶,Gupta Deepak⁶,Haagsma Juanita A.⁶,Haitsma Iain⁶,Helbok Raimund⁶,Helseth Eirik⁶,Horton Lindsay⁶,Huijben Jilske⁶,Hutchinson Peter J.⁶,Jacobs Bram⁶,Jankowski Stefan⁶,Jarrett Mike⁶,Jiang Ji-yao⁶,Johnson Faye⁶,Jones Kelly⁶,Karan Mladen⁶,Kolias Angelos G.⁶,Kompanje Erwin⁶,Kondziella Daniel⁶,Kornaropoulos Evgenios⁶,Koskinen Lars-Owe⁶,Kovács Noémi⁶,Kowark Ana⁶,Lagares Alfonso⁶,Lanyon Linda⁶,Laureys Steven⁶,Lecky Fiona⁶,Ledoux Didier⁶,Lefering Rolf⁶,Legrand Valerie⁶,Lejeune Aurelie⁶,Levi Leon⁶,Lightfoot Roger⁶,Lingsma Hester⁶,Maegele Marc⁶,Majdan Marek⁶,Manara Alex⁶,Manley Geoffrey⁶,Maréchal Hugues⁶,Martino Costanza⁶,Mattern Julia⁶,McMahon Catherine⁶,Melegh Béla⁶,Menovsky Tomas⁶,Mikolic Ana⁶,Misset Benoit⁶,Muraleedharan Visakh⁶,Murray Lynnette⁶,Nair Nandesh⁶,Negru Ancuta⁶,Nelson David⁶,Newcombe Virginia⁶,Nieboer Daan⁶,Nyirádi József⁶,Oresic Matej⁶,Ortolano Fabrizio⁶,Otesile Olubukola⁶,Palotie Aarno⁶,Parizel Paul M.⁶,Payen Jean-François⁶,Perera Natascha⁶,Perlbarg Vincent⁶,Persona Paolo⁶,Peul Wilco⁶,Piippo-Karjalainen Anna⁶,Pirinen Matti⁶,Pisica Dana⁶,Ples Horia⁶,Polinder Suzanne⁶,Pomposo Inigo⁶,Posti Jussi P.⁶,Puybasset Louis⁶,Rădoi Andreea⁶,Ragauskas Arminas⁶,Raj Rahul⁶,Rambadagalla Malinka⁶,Retel Helmrich Isabel⁶,Rhodes Jonathan⁶,Richardson Sylvia⁶,Richter Sophie⁶,Ripatti Samuli⁶,Rocka Saulius⁶,Roe Cecilie⁶,Roise Olav⁶,Rosand Jonathan⁶,Rosenfeld Jeffrey⁶,Rosenlund Christina⁶,Rosenthal Guy⁶,Rossaint Rolf⁶,Rossi Sandra⁶,Rueckert Daniel⁶,Rusnák Martin⁶,Sahuquillo Juan⁶,Sakowitz Oliver⁶,Sanchez-Porras Renan⁶,Sandor Janos⁶,Schäfer Nadine⁶,Schmidt Silke⁶,Schoechl Herbert⁶,Schoonman Guus⁶,Schou Rico Frederik⁶,Schwendenwein Elisabeth⁶,Singh Ranjit D.⁶,Sewalt Charlie⁶,Skandsen Toril⁶,Smielewski Peter⁶,Sorinola Abayomi⁶,Stamatakis Emmanuel⁶,Stanworth Simon⁶,Stevens Robert⁶,Steyerberg Ewout W.⁶,Stocchetti Nino⁶,Sundström Nina⁶,Takala Riikka⁶,Tamás Viktória⁶,Tamosuitis Tomas⁶,Taylor Mark Steven⁶,Te Ao Braden⁶,Tenovuo Olli⁶,Theadom Alice⁶,Thomas Matt⁶,Thibaut Aurore⁶,Tibboel Dick⁶,Timmers Marjolijn⁶,Tolias Christos⁶,Trapani Tony⁶,Tudora Cristina Maria⁶,Unterberg Andreas⁶,Vajkoczy Peter⁶,Valeinis Egils⁶,Vallance Shirley⁶,Vámos Zoltán⁶,van der Jagt Mathieu⁶,van der Naalt Joukje⁶,Van der Steen Gregory⁶,van Dijck Jeroen T.J.M.⁶,van Erp Inge A.⁶,van Essen Thomas A.⁶,Van Hecke Wim⁶,van Heugten Caroline⁶,Van Praag Dominique⁶,van Veen Ernest⁶,van Wijk Roel P.J.⁶,Vande Vyvere Thijs⁶,Vargiolu Alessia⁶,Vega Emmanuel⁶,Velt Kimberley⁶,Verheyden Jan⁶,Vespa Paul M.⁶,Vik Anne⁶,Vilcinis Rimantas⁶,Volovici Victor⁶,von Steinbüchel Nicole⁶,Voormolen Daphne⁶,Vulekovic Peter⁶,Wang Kevin K.W.⁶,Whitehouse Daniel⁶,Wiegers Eveline⁶,Williams Guy⁶,Winzeck Stefan⁶,Wolf Stefan⁶,Yang Zhihui⁶,Ylén Peter⁶,Younsi Alexander⁶,Zeiler Frederick A.⁶,Zelinkova Veronika⁶,Ziverte Agate⁶,Zoerle Tommaso⁶

Affiliation:

1. Division of Psychology, Faculty of Natural Sciences, University of Stirling, Stirling, United Kingdom

2. Institute of Neuroscience and Psychology, Queen Elizabeth University Hospital, University of Glasgow, Glasgow, United Kingdom

3. Sport Science, Nottingham Trent University, Nottingham, United Kingdom

4. Department of Neurosurgery, Antwerp University Hospital and University of Antwerp, Edegem, Belgium

5. Division of Anaesthesia, University of Cambridge, Cambridge, United Kingdom

6. for the CENTER-TBI participants and investigators

Abstract

ImportanceExposure to traumatic brain injury (TBI) has raised widespread concern over participation in sports, particularly over possible long-term consequences. However, little is known about the outcomes of individuals presenting to hospitals with sports-related TBI.ObjectiveTo compare the characteristics and outcomes of individuals presenting to hospitals with sports-related and non–sports-related TBI.Design, Setting, and ParticipantsThe CENTER-TBI (Collaborative European NeuroTrauma Effectiveness Research in TBI) observational cohort study was conducted at hospitals in 18 countries. The study enrolled 4509 patients who had TBI and had an indication for computed tomography (CT), of whom 4360 were 16 years or older. Outcomes were assessed at 3 and 6 months, and groups were compared using regression analyses adjusting for clinical and demographic differences. Data were collected between December 9, 2014, and December 17, 2017, and analyzed from August 2022 to March 2023.ExposureSports-related and non–sports-related TBI with subgroups selected by severity of injury.Main Outcomes and MeasuresThe main outcome was the Glasgow Outcome Scale–Extended (GOSE) at 6 months, with secondary outcomes covering postconcussion symptoms, health-related quality of life, and mental health.ResultsA total of 4360 patients were studied, including 256 (6%) with sports-related TBI (mean [SD] age, 38.9 [18.1] years; 161 [63%] male) and 4104 with non–sports-related TBI (mean [SD] age, 51.0 [20.2] years; 2773 [68%] male). Compared with patients with non–sports-related TBI, patients with sports-related TBI were younger, more likely to have tertiary education, more likely to be previously healthy, and less likely to have a major extracranial injury. After adjustment, the groups did not differ in incomplete recovery (GOSE scores &lt;8) at 6 months (odds ratio [OR], 1.27; 95% CI, 0.90-1.78; P = .22 for all patients; OR, 1.20; 95% CI, 0.83-1.73; P = .34 for those with mild TBI; and OR, 1.19; 95% CI, 0.74-1.92; P = .65 for those with mild TBI and negative CT findings). At 6 months, there was incomplete recovery in 103 of 223 patients (46%) with outcomes in the sports-related TBI group, 65 of 168 (39%) in those with mild sports-related TBI, and 30 of 98 (31%) in those with mild sports-related TBI and negative CT findings. In contrast, at 6 months, the sports-related TBI group had lower prevalence of anxiety, depression, posttraumatic stress disorder, and postconcussion symptoms than the non–sports-related group.Conclusions and RelevanceIn this cohort study of 4360 patients with TBI, functional limitations 6 months after injury were common after sports-related TBI, even mild sports-related TBI. Persisting impairment was evident in the sports-related TBI group despite better recovery compared with non–sports-related TBI on measures of mental health and postconcussion symptoms. These findings caution against taking an overoptimistic view of outcomes after sports-related TBI, even if the initial injury appears mild.

Publisher

American Medical Association (AMA)

Link

https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2814231/ntikas_2024_oi_231566_1705443687.88438.pdf

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