Effect of High-Titer Convalescent Plasma on Progression to Severe Respiratory Failure or Death in Hospitalized Patients With COVID-19 Pneumonia

Author:

Menichetti Francesco1,Popoli Patrizia2,Puopolo Maria3,Spila Alegiani Stefania2,Tiseo Giusy1,Bartoloni Alessandro4,De Socio Giuseppe Vittorio5,Luchi Sauro6,Blanc Pierluigi7,Puoti Massimo89,Toschi Elena10,Massari Marco2,Palmisano Lucia2,Marano Giuseppe11,Chiamenti Margherita12,Martinelli Laura13,Franchi Silvia13,Pallotto Carlo14,Suardi Lorenzo Roberto114,Luciani Pasqua Barbara15,Merli Marco9,Fabiani Plinio16,Bertolucci Luca16,Borchi Beatrice4,Modica Sara4,Moneta Sara6,Marchetti Giulia17,d’Arminio Monforte Antonella17,Stoppini Laura18,Ferracchiato Nadia18,Piconi Stefania19,Fabbri Claudio20,Beccastrini Enrico21,Saccardi Riccardo21,Giacometti Andrea22,Esperti Sara7,Pierotti Piera7,Bernini Laura23,Bianco Claudia23,Benedetti Sara5,Lanzi Alessandra5,Bonfanti Paolo24,Massari Marco25,Sani Spartaco26,Saracino Annalisa27,Castagna Antonella28,Trabace Luigia29,Lanza Maria30,Focosi Daniele30,Mazzoni Alessandro31,Pistello Mauro32,Falcone Marco1,Palazzolo Roberto33,Casari Salvatore33,Occhionero Alessandro33,Grazzini Tiziana33,Silvestri Dina Leonarda33,Iorio Mariacarla33,Tosti Andrea33,Francisci Daniela33,Becattini Cecilia33,Pirro Matteo33,Marchesi Mauro33,Bastianelli Sabrina33,Pierucci Sara33,Busti Chiara33,Mencacci Antonella33,Bozza Silvia33,Camilloni Barbara33,Annoni Valentina33,Bellotto Chiara33,Cioppi Adriano33,Querci Giorgia33,Ciusa Giacomo33,Tassara Michela33,Danise Anna33,Chigiotti Silvia33,Morelli Giovanna33,Meini Micaela33,Galfo Valentina33,Ferranti Simone33,Tagliaferri Enrico33,Iapoce Riccardo33,Barbieri Chiara33,Forniti Arianna33,Caroselli Claudio33,Verdenelli Stefano33,Monzani Fabio33,Mazzetti Paola33,Moscato Giovanna33,Barchiesi Francesco33,Andreotti Mauro33,Baldanti Fausto33,Binelli Andrea33,Capobianchi Maria R33,Da Cas Roberto33,Di Sevo Daniela33,Fazi Paola33,Gasparrini Cinzia33,Ippoliti Ilaria33,Mancino Alessandra33,Menniti Ippolito Francesca33,Paoloni Francesca33,Ruggeri Paola33,Rughini Arianna33,Salvi Emanuela33,Sargentini Valeria33,Trotta Maria P33,Vignetti Marco33,

Affiliation:

1. Infectious Disease Unit, Department of Clinical and Experimental Medicine, Azienda Ospedaliera Universitaria Pisana, University of Pisa, Pisa, Italy

2. National Center for Drug Research and Evaluation, Istituto Superiore di Sanità, Rome, Italy

3. Department of Neuroscience, Istituto Superiore di Sanità, Rome, Italy

4. Infectious and Tropical Diseases Unit, Florence Department of Medicine, Careggi University Hospital, Florence, Italy

5. Clinic of Infectious Diseases, “Santa Maria della Misericordia” Hospital, University of Perugia, Perugia, Italy

6. Infectious Disease Unit, Hospital of Lucca, Lucca, Italy

7. Infectious Diseases, Ospedale S. Maria Annunziata, Firenze, Italy

8. University of Milano-Bicocca School of Medicine, Milan, Italy

9. Azienda socio sanitaria territorial (ASST) Grande Ospedale Metropolitano Niguarda, Milan, Italy

10. Research Coordination and Support Service (CoRi), Istituto Superiore di Sanità, Rome, Italy

11. Italian National Blood Centre, Rome, Italy

12. Unit of Infectious Diseases, Carlo Poma Hospital, Mantova, Italy

13. Internal Medicine, Unità Sanitaria Locale (USL)–Umbria 1, Ospedale Città di Castello, Città di Castello, Italy

14. Infectious Diseases Unit, San Giuseppe Hospital, Azienda USL Toscana Centro, Empoli, Italy

15. Centro Regionale Sangue, Servizio Immunotrasfusionale, Azienda Ospedaliera di Perugia, Perugia, Italy

16. Internal Medicine, Ospedale Unico della Versilia, Lido di Camaiore, Italy

17. Infectious Diseases Unit, Department of Health Sciences, ASST Santi Paolo e Carlo University Hospital, Milan, Italy

18. Internal Medicine, Ospedale di Foligno, Foligno, Italy

19. Infectious Diseases, Azienda Ospedaliera di Lecco, Lecco, Italy

20. Infectious Diseases, Ospedale San Jacopo, Pistoia, Italy

21. Cell Therapy and Transfusion Medicine, Careggi University Hospital, Florence, Italy

22. Azienda Ospedaliera Universitaria, Ospedali Riuniti di Ancona, Ancona, Italy

23. Division of Infectious Diseases, Arezzo Hospital, Arezzo, Italy

24. Department of Infectious Diseases, ASST Monza, University of Milano-Bicocca, Milan, Italy

25. Infectious Disease Unit, Azienda USL–Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) di Reggio Emilia, Reggio Emilia, Italy

26. Infectious Diseases, Livorno Hospital, Livorno, Italy

27. Division of Infectious Diseases, Bari University Hospital, Bari, Italy

28. Infectious Diseases, IRCCS Ospedale San Raffaele, Università Vita-Salute San Raffaele, Milan, Italy

29. Department of Experimental and Clinical Medicine, University of Foggia, Foggia, Italy

30. North-Western Tuscany Blood Bank, Pisa University Hospital, Pisa, Italy

31. Division of Transfusion Medicine and Transplant Biology, Pisa University Hospital, Pisa, Italy

32. Division of Virology, University Hospital of Pisa, Retrovirus Center, Department of Translational Research, University of Pisa, Pisa, Italy

33. for the TSUNAMI Study group

Publisher

American Medical Association (AMA)

Subject

General Medicine

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