Amygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals-Reference-Cited by-同舟云学术

Amygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals

Published:2024-09-09 Issue:9 Volume:7 Page:e2432387
ISSN:2574-3805
Container-title:JAMA Network Open
language:en
Short-container-title:JAMA Netw Open

Author:

Korem Nachshon¹²³,Hillmer Ansel T.¹⁴⁵⁶,D’Souza Deepak Cyril¹³,Bassir Nia Anahita¹,Levy Ifat²⁶⁷⁸,Pietrzak Robert H.¹³,Harpaz-Rotem Ilan¹³⁶⁷

Affiliation:

1. Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut

2. Department of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut

3. US Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, VA Connecticut Healthcare System, West Haven, Connecticut

4. Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut

5. Department of Biomedical Engineering, Yale School of Engineering and Applied Sciences, Yale University, New Haven, Connecticut

6. Wu Tsai Institute, Yale University New Haven, New Haven, Connecticut

7. Department of Psychology, Yale University, New Haven, Connecticut

8. Department of Neuroscience, Yale University, New Haven, Connecticut

Abstract

This case-control study assesses associations of amygdala cannabinoid 1 receptor availability with amygdala response to shock-induced pain and severity of emotional numbing symptoms of veterans with posttraumatic stress disorder.

Publisher

American Medical Association (AMA)

Link

https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2823186/korem_2024_ld_240143_1724790311.02348.pdf

Reference6 articles.

1. Emotional numbing in PTSD is associated with lower amygdala reactivity to pain.;Korem;Neuropsychopharmacology,2022

2. Emotional state transitions in trauma-exposed individuals with and without posttraumatic stress disorder.;Korem;JAMA Netw Open,2024

3. Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the World Trade Center attacks.;Hill;Psychoneuroendocrinology,2013

4. Imaging the cannabinoid CB1 receptor in humans with [11C]OMAR: assessment of kinetic analysis methods, test-retest reproducibility, and gender differences.;Normandin;J Cereb Blood Flow Metab,2015

5. Links between central CB1-receptor availability and peripheral endocannabinoids in patients with first episode psychosis.;Dickens;NPJ Schizophr,2020