Effects of Meditation Training and Non-Native Language Training on Cognition in Older Adults
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Published:2023-07-14
Issue:7
Volume:6
Page:e2317848
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ISSN:2574-3805
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Container-title:JAMA Network Open
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language:en
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Short-container-title:JAMA Netw Open
Author:
Demnitz-King Harriet1, Requier Florence23, Whitfield Tim1, Schlosser Marco14, Gonneaud Julie5, Ware Caitlin56, Barnhofer Thorsten7, Coll-Padros Nina8, Dautricourt Sophie59, Delarue Marion5, Klimecki Olga M.10, Paly Léo5, Salmon Eric23, Schild Ann-Katrin11, Wirth Miranka12, Frison Eric1314, Lutz Antoine15, Chételat Gaël5, Collette Fabienne23, Marchant Natalie L.1, Allais Florence16, André Claire16, Arenaza-Urquijo Eider16, Asselineau Julien16, Baez Lugo Sebastian16, Batchelor Martine16, Beaugonin Axel16, Bejanin Alexandre16, Botton Maelle16, Champetier Pierre16, Chocat Anne16, De Flores Robin16, De La Sayette Vincent16, Delamilleure Pascal16, Egret Stéphanie16, Espérou Hélene16, Felisatti Francesca16, Ferrand-Devouges Eglantine16, Garnier-Groussard Antoine16, Gheysen Francis16, Heidmann Marc16, Hendy Anne16, Huong Tran Thien16, Joret Philippe Agathe16, Kuhn Elizabeth16, Landeau Brigitte16, Le Du Gwendoline16, Lefranc Valérie16, Mezenge Florence16, Moulinet Inés16, Ourry Valentin16, Palix Cassandre16, Quillard Anne16, Rauchs Géraldine16, Rehel Stéphane16, Schwimmer Corrine16, Sherif Siya16, Tomadesso Clémence16, Touron Edelweiss16, Vanhoutte Matthieu16,
Affiliation:
1. Division of Psychiatry, University College London, London, United Kingdom, W1T 7NF 2. GIGA-CRC In Vivo Imaging, University of Liège, Liège, Belgium 3. Psychology and Cognitive Neuroscience Unit, University of Liège, Liège, Belgium 4. Department of Psychology, Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland 5. Normandie Univ, UNICAEN, INSERM, U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), Institut Blood and Brain @ Caen-Normandie, Cyceron, France 6. Centre de recherches psychanalyse, médecine et société (CPRMS), Université de Paris, Paris, France 7. School of Psychology, University of Surrey, Guildford, United Kingdom 8. Alzheimer’s Disease and Other Cognitive Disorders Unit, Hospital Clinic, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain 9. Neurology Department, University Hospital, Caen, France 10. Clinical Psychology and Behavioral Neuroscience, Faculty of Psychology, Technische Universität Dresden, Dresden, Germany 11. Department of Psychiatry, Medical Faculty, University of Cologne, Cologne, Germany 12. German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany 13. Bordeaux Population Health Center, University of Bordeaux, INSERM, EUCLID/F-CRIN Clinical Trials Platform, CHU Bordeaux, Bordeaux, France 14. Service d’information médicale, CHU Bordeaux, Bordeaux, France 15. Eduwell team, Lyon Neuroscience Research Center INSERM U1028, CNRS UMR5292, Lyon 1 University, Bron, Lyon, France 16. for the Medit-Ageing Research Group
Abstract
ImportanceNonpharmacological interventions are a potential strategy to maintain or promote cognitive functioning in older adults.ObjectiveTo investigate the effects of 18 months’ meditation training and 18 months’ non-native language training on cognition in older adults.Design, Setting, and ParticipantsThis study was a secondary analysis of the Age-Well trial, an 18-month, observer-masked, randomized clinical trial with 3 parallel arms. Eligible participants were community-dwelling adults aged 65 years and older residing in Caen, France. Participants were enrolled from November 24, 2016, to March 5, 2018, and randomly assigned (1:1:1) to meditation training, non-native language (English) training, or no intervention arms. Final follow-up was completed on February 6, 2020. Data were analyzed between December 2021 and November 2022.InterventionsThe 18-month meditation and non-native language training interventions were structurally equivalent and included 2-hour weekly group sessions, daily home practice of 20 minutes or longer, and 1 day of more intensive home practice. The no intervention group was instructed not to change their habits and to continue living as usual.Main Outcomes and MeasuresCognition (a prespecified secondary outcome of the Age-Well trial) was assessed preintervention and postintervention via the Preclinical Alzheimer Cognitive Composite 5 (PACC5), and composites assessing episodic memory, executive function, and attention.ResultsAmong 137 randomized participants, 2 were excluded for not meeting eligibility criteria, leaving 135 (mean [SD] age, 69.3 [3.8] years; 83 female [61%]) eligible for analysis. One participant among the remaining 135 did not complete the trial. In adjusted mixed effects models, no interaction effects were observed between visit and group for PACC5 (F2,131.39 = 2.58; P = .08), episodic memory (F2,131.60 = 2.34; P = .10), executive function (F2,131.26 = 0.89; P = .41), or attention (F2,131.20 = 0.34; P = .79). Results remained substantively unchanged across sensitivity and exploratory analyses.Conclusions and RelevanceIn this secondary analysis of an 18-month randomized trial, meditation and non-native language training did not confer salutary cognitive effects. Although further analyses are needed to explore the effects of these interventions on other relevant outcomes related to aging and well-being, these findings did not support the use of these interventions for enhancing cognition in cognitively healthy older adults.Trial RegistrationClinicalTrials.gov Identifier: NCT02977819
Publisher
American Medical Association (AMA)
Cited by
2 articles.
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