Clinical Trial Evidence Supporting US Food and Drug Administration Approval of Novel Cancer Therapies Between 2000 and 2016

Author:

Ladanie Aviv12,Schmitt Andreas M.3,Speich Benjamin14,Naudet Florian5,Agarwal Arnav67,Pereira Tiago V.89,Sclafani Francesco10,Herbrand Amanda K.311,Briel Matthias17,Martin-Liberal Juan12,Schmid Thomas11,Ewald Hannah1213,Ioannidis John P. A.1415161718,Bucher Heiner C.1,Kasenda Benjamin13,Hemkens Lars G.1

Affiliation:

1. Department of Clinical Research, Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital and University of Basel, Basel, Switzerland

2. Swiss Tropical and Public Health Institute, Basel, Switzerland

3. Medical Oncology, University Hospital and University of Basel, Basel, Switzerland

4. Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom

5. Universite de Rennes, CHU Rennes, Inserm, CIC 1414–Centre d’Investigation Clinique de Rennes, Rennes, France

6. Department of Medicine, University of Toronto, Toronto, Ontario, Canada

7. Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada

8. Applied Health Research Centre, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Ontario, Canada

9. Department of Health Sciences, College of Medicine, University of Leicester, Leicester, United Kingdom

10. Department of Medical Oncology, Institut Jules Bordet, Brussels, Belgium

11. St Clara Hospital, Basel, Switzerland

12. Melanoma, Sarcoma and GU Tumors Unit, Catalan Institute of Oncology Hospitalet, Barcelona, Spain

13. University Medical Library, University of Basel, Basel, Switzerland

14. Meta-Research Innovation Center at Stanford, Stanford University, Stanford, California

15. Department of Medicine, Stanford University School of Medicine, Stanford, California

16. Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, California

17. Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, California

18. Department of Statistics, Stanford University School of Humanities and Sciences, Stanford, California

Publisher

American Medical Association (AMA)

Subject

General Medicine

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