Implementation of Recommendations on the Use of Corticosteroids in Severe COVID-19

Author:

Camirand-Lemyre Félix1,Merson Laura2,Tirupakuzhi Vijayaraghavan Bharath Kumar34,Burrell Aidan J. C.56,Citarella Barbara Wanjiru2,Domingue Marie-Pier1,Lévesque Simon1,Usuf Effua7,Wils Evert-Jan89,Ohshimo Shinichiro10,Martin-Loeches Ignacio11,Sǎndulescu Oana1213,Laake Jon Henrik14,Lamontagne François1,Abdukahil Sheryl Ann15,Abdulkadir Nurul Najmee15,Abe Ryuzo15,Abel Laurent15,Abrous Amal15,Absil Lara15,Abu Jabal Kamal15,Abu Salah Nashat15,Acker Andrew15,Adam Elisabeth15,Adrião Diana15,Ageel Saleh Al15,Ahmed Shakeel15,Ainscough Kate15,Airlangga Eka15,Aisa Tharwat15,Ait Hssain Ali15,Ait Tamlihat Younes15,Akimoto Takako15,Akmal Ernita15,Akwani Chika15,Al Qasim Eman15,Alalqam Razi15,Alameen Aliya Mohammed15,Alberti Angela15,Al-dabbous Tala15,Alegesan Senthilkumar15,Alessi Marta15,Alex Beatrice15,Alexandre Kévin15,Al-Fares Abdulrahman15,Alfoudri Huda15,Ali Imran15,Ali Adam15,Alidjnou Kazali Enagnon15,Alkhafajee Qabas15,Allavena Clotilde15,Allou Nathalie15,Alves João15,Alves Rita15,Alves João Melo15,Alves Cabrita Joana15,Amaral Maria15,Amira Nur15,Andini Roberto15,Andréjak Claire15,Angheben Andrea15,Angoulvant François15,Ansart Séverine15,Anthonidass Sivanesen15,Antonelli Massimo15,Antunes de Brito Carlos Alexandre15,Apriyana Ardiyan15,Arabi Yaseen15,Aragao Irene15,Arancibia Francisco15,Araujo Carolline15,Arcadipane Antonio15,Archambault Patrick15,Arenz Lukas15,Arlet Jean-Benoît15,Arnold-Day Christel15,Arora Lovkesh15,Arora Rakesh15,Artaud-Macari Elise15,Asensio Angel15,Ashley Elizabeth A.15,Ashraf Muhammad15,Assie Jean Baptiste15,Asyraf Amirul15,Atif Minahel15,Atique Anika15,Attanyake AM Udara Lakshan15,Auchabie Johann15,Aumaitre Hugues15,Auvet Adrien15,Axelsen Eyvind W.15,Azemar Laurène15,Azoulay Cecile15,Babatunde Hakeem15,Bach Benjamin15,Bachelet Delphine15,Badr Claudine15,Bævre-Jensen Roar15,Baig Nadia15,Baillie John Kenneth15,Baird J Kevin15,Bak Erica15,Bakakos Agamemnon15,Bakar Nazreen Abu15,Bal Andriy15,Balakrishnan Mohanaprasanth15,Bani-Sadr Firouzé15,Barbalho Renata15,Barbosa Nicholas Yuri15,Barclay Wendy S.15,Barnett Saef Umar15,Barnikel Michaela15,Barrasa Helena15,Barrigoto Cleide15,Bartoli Marie15,Baruch Joaquín15,Basmaci Romain15,Basri Muhammad Fadhli Hassin15,Battaglini Denise15,Bauer Jules15,Bautista Rincon Diego Fernando15,Bazan Dow Denisse15,Beane Abigail15,Bedossa Alexandra15,Bee Ker Hong15,Begum Husna15,Behilill Sylvie15,Beishuizen Albertus15,Beljantsev Aleksandr15,Bellemare David15,Beltrame Anna15,Beltrão Beatriz Amorim15,Beluze Marine15,Benech Nicolas15,Benjiman Lionel Eric15,Bennett Suzanne15,Bento Luís15,Berdal Jan-Erik15,Bergeaud Delphine15,Bergin Hazel15,Bernal Sobrino José Luis15,Bertoli Giulia15,Bertolino Lorenzo15,Bessis Simon15,Bevilcaqua Sybille15,Bezulier Karine15,Bhatt Amar15,Bhavsar Krishna15,Bianco Claudia15,Bidin Farah Nadiah15,Bin Humaid Felwa15,Bin Kamarudin Mohd Nazlin15,Bisoffi Zeno15,Biston Patrick15,Bitker Laurent15,Bittaye Mustapha15,Bitton Jonathan15,Blanco-Schweizer Pablo15,Blier Catherine15,Bloos Frank15,Blot Mathieu15,Boccia Filomena15,Bodenes Laetitia15,Bogaert Debby15,Boivin Anne-Hélène15,Bolaños Isabela15,Bolze Pierre-Adrien15,Bompart François15,Bonfasius Aurelius15,Borges Diogo15,Borie Raphaël15,Bosse Hans Martin15,Botelho-Nevers Elisabeth15,Bouadma Lila15,Bouchaud Olivier15,Bouchez Sabelline15,Bouhmani Dounia15,Bouhour Damien15,Bouiller Kévin15,Bouillet Laurence15,Bouisse Camile15,Bountthasavong Latsaniphone15,Boureau Anne-Sophie15,Bourke John15,Bouscambert Maude15,Bousquet Aurore15,Bouziotis Jason15,Boyer-Besseyre Marielle15,Boylan Maria15,Bozza Fernando Augusto15,Braconnier Axelle15,Braga Cynthia15,Brandenburger Timo15,Brás Monteiro Filipa15,Brazzi Luca15,Breen Patrick15,Breen Dorothy15,Brewster David15,Brickell Kathy15,Broadley Tessa15,Brotherton Helen15,Browne Shaunagh15,Browne Alex15,Brozzi Nicolas15,Brunvoll Sonja Hjellegjerde15,Brusse-Keizer Marjolein15,Bryda Petra15,Buchtele Nina15,Bugaeva Polina15,Buisson Marielle15,Buonsenso Danilo15,Burhan Erlina15,Bustos Ingrid G.15,Butnaru Denis15,Cabie André15,Cabral Susana15,Cabrita Joana15,Caceres Eder15,Cadoz Cyril15,Caetano Garcês Rui15,Calligy Kate15,Calvache Jose Andres15,Camões João15,Campana Valentine15,Campbell Paul15,Campisi Josie15,Canepa Cecilia15,Cantero Mireia15,Caoili Janice15,Caraux-Paz Pauline15,Cárcel Sheila15,Cardoso Sofia15,Cardoso Filipe15,Cardoso Filipa15,Cardoso Nelson15,Carelli Simone15,Carlier Nicolas15,Carmoi Thierry15,Carney Gayle15,Carqueja Inês15,Carret Marie-Christine15,Carrier François Martin15,Carroll Ida15,Carson Gail15,Casanova Maire-Laure15,Cascão Mariana15,Casey Siobhan15,Casimiro José15,Cassandra Bailey15,Castañeda Silvia15,Castanheira Nidyanara15,Castor-Alexandre Guylaine15,Castro Ivo15,Catarino Ana15,Catherine François-Xavier15,Cattaneo Paolo15,Cavalin Roberta15,Cavalli Giulio Giovanni15,Cavayas Alexandros15,Ceccato Adrian15,Ceesay Masaneh15,Cervantes-Gonzalez Minerva15,Cevik Muge15,Chair Anissa15,Chakveatze Catherine15,Chan Adrienne15,Chand Meera15,Chapplain Jean-Marc15,Charpentier Charlotte15,Chas Julie15,Chávez Iñiguez Jonathan Samuel15,Chen Anjellica15,Chen Yih-Sharng15,Chenard Léo15,Cheng Matthew Pellan15,Cheret Antoine15,Chiarabini Thibault15,Chica Julian15,Chidambaram Suresh Kumar15,Chin Tho Leong15,Chirouze Catherine15,Chiumello Davide15,Cho Sung-Min15,Cholley Bernard15,Chommanam Danoy15,Chopin Marie-Charlotte15,Chow Ting Soo15,Christy Nathaniel15,Chua Hiu Jian15,Chua Jonathan15,Cidade Jose Pedro15,Cisneros Herreros José Miguel15,Ciullo Anna15,Clarke Jennifer15,Claure-Del Granado Rolando15,Clohisey Sara15,Codan Cassidy15,Cody Caitriona15,Coles Jennifer15,Colin Gwenhaël15,Collins Michael15,Combs Pamela15,Connolly Jennifer15,Connor Marie15,Conrad Anne15,Conway Elaine15,Cooke Graham S.15,Cordel Hugues15,Corley Amanda15,Cornelis Sabine15,Cornet Alexander Daniel15,Corpuz Arianne Joy15,Cortegiani Andrea15,Corvaisier Grégory15,Couffignal Camille15,Couffin-Cadiergues Sandrine15,Courtois Roxane15,Cousse Stéphanie15,Cregan Rachel15,Cristella Cosimo15,Crowl Gloria15,Crump Jonathan15,Cruz Claudina15,Cruz Bermúdez Juan Luis15,Cruz Rojo Jaime15,Csete Marc15,Cullen Ailbhe15,Cummings Matthew15,Curley Gerard15,Curlier Elodie15,Curran Colleen15,Custodio Paula15,da Silva Filipe Ana15,Da Silveira Charlene15,Dabaliz Al-Awwab15,Dagens Andrew15,Dahl John Arne15,Dahly Darren15,D'Alessandro Umberto15,Daley Peter15,Dalton Jo15,Dalton Heidi15,Daly Seamus15,Damas Juliana15,Daneman Nick15,Dankwa Emmanuelle A15,Dantas Jorge15,D'Aragon Frédérick15,de Jong Menno15,de Loughry Gillian15,de Mendoza Diego15,De Montmollin Etienne15,de Oliveira França Rafael Freitas15,de Pinho Oliveira Ana Isabel15,De Rosa Rosanna15,De Rose Cristina15,de Silva Thushan15,de Vries Peter15,Deacon Jillian15,Dean David15,Debard Alexa15,DeBenedictis Bianca15,Debray Marie-Pierre15,DeCastro Nathalie15,Dechert William15,Decours Romain15,Defous Eve15,Delacroix Isabelle15,Delaveuve Eric15,Delavigne Karen15,Delfos Nathalie M.15,Deligiannis Ionna15,Dell'Amore Andrea15,Delmas Christelle15,Delobel Pierre15,Delsing Corine15,Demonchy Elisa15,Denis Emmanuelle15,Deplanque Dominique15,Depuydt Pieter15,Desai Mehul15,Descamps Diane15,Desvallées Mathilde15,Dewayanti Santi15,Dhangar Pathik15,Diallo Alpha15,Diamantis Sylvain15,Dias André15,Dias Da Silva Fernanda15,Diaz Juan Jose15,Diaz Rodrigo15,Diaz Priscila15,Dibba Bakary K15,Didier Kévin15,Diehl Jean-Luc15,Dieperink Wim15,Dimet Jérôme15,Dinot Vincent15,Diop Fara15,Diouf Alphonsine15,Dishon Yael15,Djossou Félix15,Docherty Annemarie B.15,Doherty Helen15,Dondorp Arjen M15,Donnelly Christl A.15,Donohue Sean15,Donohue Yoann15,Doran Peter15,Dorival Céline15,D'Ortenzio Eric15,Doshi Yash15,Douangdala Phouvieng15,Douglas James Joshua15,Douma Renee15,Dournon Nathalie15,Downey Joanne15,Downing Mark15,Drake Thomas15,Driscoll Aoife15,Dror Amiel A.15,Dryden Murray15,Duarte Fonseca Claudio15,Dubee Vincent15,Dubos François15,Dubot-Pérès Audrey15,Ducancelle Alexandre15,Duculan Toni15,Dudman Susanne15,Duggal Abhijit15,Dunand Paul15,Dunning Jake15,Duplaix Mathilde15,Durante-Mangoni Emanuele15,Durham III Lucian15,Dussol Bertrand15,Duthoit Juliette15,Duval Xavier15,Dyrhol-Riise Anne Margarita15,Ean Sim Choon15,Echeverria-Villalobos Marco15,Edelstein Michael15,Egan Siobhan15,Eggesbø Linn Margrete15,Eira Carla15,El Sanharawi Mohammed15,Elapavaluru Subbarao15,Elharrar Brigitte15,Ellerbroek Jacobien15,Ellingjord-Dale Merete15,Elotmani Loubna15,Eloy Philippine15,Elshazly Tarek15,Elyazar Iqbal15,Enderle Isabelle15,Endo Tomoyuki15,Eng Chan Chee15,Engelmann Ilka15,Enouf Vincent15,Epaulard Olivier15,Escher Martina15,Esperatti Mariano15,Esperou Hélène15,Espírito Santo Catarina15,Esposito-Farese Marina15,Estevão João15,Etienne Manuel15,Everding Anna Greti15,Evers Mirjam15,Fabre Marc15,Fabre Isabelle15,Fadera Ismaila15,Faheem Amna15,Fahy Arabella15,Fairfield Cameron J.15,Faria Pedro15,Fateena Hanan15,Fatoni Arie Zainul15,Faure Karine15,Favory Raphaël15,Fayed Mohamed15,Feely Niamh15,Fernandes Jorge15,Fernandes Marília Andreia15,Fernandes Susana15,Ferrand François-Xavier15,Ferrand Devouge Eglantine15,Ferrão Joana15,Ferraz Mário15,Ferreira Sílvia15,Ferreira Bernardo15,Ferreira Benigno15,Ferreira Isabel15,Ferriere Nicolas15,Ficko Céline15,Figueiredo-Mello Claudia15,Finlayson William15,Flament Thomas15,Fletcher Tom15,Florence Aline-Marie15,Florio Letizia Lucia15,Flynn Deirdre15,Flynn Brigid15,Foley Jean15,Fomin Victor15,Fonseca Tatiana15,Fontela Patricia15,Forrest Karen15,Forsyth Simon15,Foster Denise15,Foti Giuseppe15,Fourn Erwan15,Fowler Robert A.15,Fraher Marianne15,Franch-Llasat Diego15,Fraser John F.15,Fraser Christophe15,Freire Marcela Vieira15,Freitas Ribeiro Ana15,Friedrich Caren15,Fritz Ricardo15,Fry Stéphanie15,Fuentes Nora15,Fukuda Masahiro15,G Argin15,Gaborieau Valérie15,Gaci Rostane15,Gagliardi Massimo15,Gagnard Jean-Charles15,Gagneux-Brunon Amandine15,Gai Abdou15,Gaião Sérgio15,Gail Skeie Linda15,Gallagher Phil15,Gamble Carrol15,Gani Yasmin15,Garan Arthur15,Garcia Rebekha15,García Barrio Noelia15,Garcia-Diaz Julia15,Garcia-Gallo Esteban15,Garimella Navya15,Garot Denis15,Garrait Valérie15,Gavrylov Anatoliy15,Gaymard Alexandre15,Gebauer Johannes15,Geraud Eva15,Gerbaud Morlaes Louis15,Germano Nuno15,Ghisulal Praveen Kumar15,Ghosn Jade15,Giani Marco15,Gigante Tristan15,Gilroy Elaine15,Giordano Guillermo15,Girvan Michelle15,Gissot Valérie15,Glikman Daniel15,Glybochko Petr15,Gnall Eric15,Goco Geraldine15,Goehringer François15,Goepel Siri15,Goffard Jean-Christophe15,Goh Jin Yi15,Golob Jonathan15,Gomes Rui15,Gomez Kyle15,Gómez-Junyent Joan15,Gominet Marie15,Gonzalez Alicia15,Gordon Patricia15,Gorelik Yanay15,Gorenne Isabelle15,Goubert Laure15,Goujard Cécile15,Goulenok Tiphaine15,Grable Margarite15,Graf Jeronimo15,Grandin Edward Wilson15,Granier Pascal15,Grasselli Giacomo15,Green Christopher A.15,Greene Courtney15,Greenhalf William15,Greffe Segolène15,Grieco Domenico Luca15,Griffee Matthew15,Griffiths Fiona15,Grigoras Ioana15,Groenendijk Albert15,Gruner Heidi15,Gu Yusing15,Guedj Jérémie15,Guego Martin15,Guerguerian Anne-Marie15,Guerreiro Daniela15,Guery Romain15,Guillaumot Anne15,Guilleminault Laurent15,Guimarães de Castro Maisa15,Guimard Thomas15,Haalboom Marieke15,Haber Daniel15,Hachemi Ali15,Hadri Nadir15,Hakak Sheeba15,Hall Adam15,Hall Matthew15,Halpin Sophie15,Hamer Ansley15,Hamers Raph L.15,Hamidfar Rebecca15,Hammarström Bato15,Hammond Terese15,Hammond Naomi15,Han Lim Yuen15,Haniffa Rashan15,Hao Kok Wei15,Hardwick Hayley15,Harrison Ewen M.15,Harrison Janet15,Harrison Samuel Bernard Ekow15,Hartman Alan15,Hashmi Junaid15,Hayes Ailbhe15,Hays Leanne15,Heerman Jan15,Heggelund Lars15,Hendry Ross15,Hennessy Martina15,Henriquez-Trujillo Aquiles Rodrigo15,Hentzien Maxime15,Hernandez Diana15,Herr Daniel15,Hershey Andrew15,Hesstvedt Liv15,Hidayah Astarini15,Higgins Eibhlin15,Higgins Rupert15,Hinton Samuel15,Hiraiwa Hiroaki15,Hirkani Haider15,Hitoto Hikombo15,Ho Antonia15,Ho Yi Bin15,Hoctin Alexandre15,Hoffmann Isabelle15,Hoh Wei Han15,Hoiting Oscar15,Holt Rebecca15,Holter Jan Cato15,Horby Peter15,Horcajada Juan Pablo15,Houas Ikram15,Hough Catherine L.15,Houltham Stuart15,Hsu Jimmy Ming-Yang15,Hulot Jean-Sébastien15,Huo Stella15,Hurd Abby15,Ijaz Samreen15,Ikram M. Arfan15,Illana Carlos Cañada15,Imbert Patrick15,Inácio Hugo15,Infante Dominguez Carmen15,Ing Yun Sii15,Iosifidis Elias15,Ippolito Mariachiara15,Isgett Sarah15,Isidoro Tiago15,Ismail Nadiah15,Isnard Margaux15,Istre Mette Stausland15,Itai Junji15,Ivulich Daniel15,Jaafar Danielle15,Jaafoura Salma15,Jabot Julien15,Jackson Clare15,Jagne Abubacarr15,Janes Victoria15,Jaureguiberry Stéphane15,Jaworsky Denise15,Jego Florence15,Jelani Anilawati Mat15,Jenum Synne15,Jimbo-Sotomayor Ruth15,Joe Ong Yiaw15,Jorge García Ruth Noemí15,Jørgensen Silje Bakken15,Joseph Mark15,Joseph Cédric15,Joshi Swosti15,Jourdain Mercé15,Jouvet Philippe15,Jung Anna15,Jung Hanna15,Juzar Dafsah15,Kafif Ouifiya15,Kaguelidou Florentia15,Kaisbain Neerusha15,Kaleesvran Thavamany15,Kali Sabina15,Kalicinska Alina15,Kalleberg Karl Trygve15,Kalomoiri Smaragdi15,Kamaluddin Muhammad Aisar Ayadi15,Kamaruddin Zul Amali Che15,Kamarudin Nadiah15,Kandamby Darshana Hewa15,Kang Kong Yeow15,Kanyawati Dyah15,Karpayah Pratap15,Kartsonaki Christiana15,Kasugai Daisuke15,Katz Kevin15,Kay Christy15,Kayyali Lamees15,Keating Seán15,Kedia Pulak15,Kelly Claire15,Kelly Yvelynne15,Kelly Andrea15,Kelly Niamh15,Kelly Aoife15,Kelly Sadie15,Kelsey Maeve15,Kennon Kalynn15,Keomany Sommay15,Kernan Maeve15,Kerroumi Younes15,Keshav Sharma15,Khalid Imrana15,Khalil Antoine15,Khan Irfan15,Kherajani Krish15,Kho Michelle E.15,Khoo Saye15,Khoo Ryan15,Khoo Denisa15,Kiat Khor How15,Kida Yuri15,Kiiza Peter15,Kiland Granerud Beathe15,Kildal Anders Benjamin15,Kim Jae Burm15,Kimmoun Antoine15,Kindgen-Milles Detlef15,Kitamura Nobuya15,Kjetland Eyrun Floerecke Kjetland15,Klenerman Paul15,Klont Rob15,Kloumann Bekken Gry15,Knight Stephen R15,Kobbe Robin15,Kodippily Chamira15,Kohns Vasconcelos Malte15,Komatsu Mamoru15,Korten Volkan15,Kpangon Arsène15,Krawczyk Karolina15,Krishnan Sudhir15,Krishnan Vinothini15,Kruglova Oksana15,Kuan Pei Xuan15,Kumar Deepali15,Kumar Ganesh15,Kuriakose Dinesh15,Kurtzman Ethan15,Kusumastuti Neurinda Permata15,Kutsogiannis Demetrios15,Kutsyna Galyna15,Kyriakoulis Konstantinos15,Lachatre Marie15,Lacoste Marie15,Laffey John G.15,Lafhej Nadhem15,Lagrange Marie15,Laine Fabrice15,Lairez Olivier15,Lalueza Antonio15,Lambert Marc15,Langelot-Richard Marie15,Langlois Vincent15,Lantang Eka Yudha15,Lanza Marina15,Laouénan Cédric15,Laribi Samira15,Lariviere Delphine15,Lasry Stéphane15,Lath Sakshi15,Launay Odile15,Laureillard Didier15,Lavie-Badie Yoan15,Law Andy15,Lawrence Teresa15,Lawrence Cassie15,Le Minh15,Le Bihan Clément15,Le Bris Cyril15,Le Falher Georges15,Le Fevre Lucie15,Le Hingrat Quentin15,Le Maréchal Marion15,Le Mestre Soizic15,Le Moal Gwenaël15,Le Moing Vincent15,Le Nagard Hervé15,Leal Ema15,Leal Santos Marta15,Lee Todd C.15,Lee Su Hwan15,Lee James15,Lee Heng Gee15,Lee Biing Horng15,Lee Yi Lin15,Lee Jennifer15,Leeming Gary15,Lefebvre Laurent15,Lefebvre Bénédicte15,Lefèvre Benjamin15,LeGac Sylvie15,Lelievre Jean-Daniel15,Lellouche François15,Lemaignen Adrien15,Lemee Véronique15,Lemeur Anthony15,Lemmink Gretchen15,Lene Ha Sha15,Lennon Jenny15,León Rafael15,Leone Marc15,Lepiller Quentin15,Lescure François-Xavier15,Lesens Olivier15,Lesouhaitier Mathieu15,Lester-Grant Amy15,Letizia Andrew15,Letrou Sophie15,Levy Yves15,Levy Bruno15,Levy-Marchal Claire15,Lewandowska Katarzyna15,L'Her Erwan15,Li Bassi Gianluigi15,Liang Janet15,Liegeon Geoffrey15,Lim Wei Shen15,Lim Kah Chuan15,Lima Chantre15,Lina Lim15,Lina Bruno15,Lind Andreas15,Lingad Maja Katherine15,Lingas Guillaume15,Lion-Daolio Sylvie15,Lissauer Samantha15,Liu Keibun15,Livrozet Marine15,Lizotte Patricia15,Loforte Antonio15,Lolong Navy15,Loon Leong Chee15,Lopes Diogo15,Lopez-Colon Dalia15,Lopez-Revilla Jose W.15,Loschner Anthony L.15,Loubet Paul15,Loufti Bouchra15,Louis Guillame15,Lourenco Silvia15,Lovelace-Macon Lara15,Low Lee Lee15,Lowik Marije15,Loy Jia Shyi15,Lucet Jean Christophe15,Lumbreras Bermejo Carlos15,Luna Carlos M.15,Lungu Olguta15,Lunn Miles15,Luong Liem15,Luque Nestor15,Luton Dominique15,Maasikas Olavi15,Machado Sara15,Machado Moïse15,Macheda Gabriel15,Maestro de la Calle Guillermo15,Mahieu Rafael15,Mahy Sophie15,Maia Ana Raquel15,Maier Lars S.15,Maillet Mylène15,Maitre Thomas15,Malfertheiner Maximilian15,Malik Nadia15,Mallon Paddy15,Maltez Fernando15,Malvy Denis15,Manda Victoria15,Mandei Jose M.15,Mandelbrot Laurent15,Manetta Frank15,Mankikian Julie15,Manning Edmund15,Manuel Aldric15,Maria Sant`Ana Malaque Ceila15,Marino Flávio15,Markowicz Samuel15,Marques Ana15,Marquis Catherine15,Marsh Brian15,Marshal Megan15,Marshall John15,Martelli Celina Turchi15,Martin Dori-Ann15,Martin Emily15,Martin-Blondel Guillaume15,Martinez F. Eduardo15,Martinot Martin15,Martín-Quiros Alejandro15,Martins João15,Martins Ana15,Martins Nuno15,Martins Rego Caroline15,Martucci Gennaro15,Martynenko Olga15,Marwali Eva Miranda15,Marzukie Marsilla15,Maslove David15,Mason Sabina15,Matan Moshe15,Mateus Fernandes Henrique15,Mattei Mathieu15,Maulin Laurence15,Maynar Javier15,Mayxay Mayfong15,Mazzoni Thierry15,Mc Sweeney Lisa15,McArthur Colin15,McCann Naina15,McCanny Peter15,McCarthy Anne15,McCarthy Aine15,McCloskey Colin15,McConnochie Rachael15,McDermott Sherry15,McDonald Sarah E.15,McElroy Aine15,McElwee Samuel15,McEvoy Natalie15,McGeer Allison15,McLean Kenneth A.15,McNally Paul15,McNicholas Bairbre15,Meaney Edel15,Mear-Passard Cécile15,Mechlin Maggie15,Mehkri Omar15,Mele Ferruccio15,Melo Luis15,Mendes João João15,Menkiti Ogechukwu15,Menon Kusum15,Mentré France15,Mentzer Alexander J.15,Mercier Noémie15,Mercier Emmanuelle15,Merckx Antoine15,Mergeay-Fabre Mayka15,Mergler Blake15,Mesquita António15,Meta Roberta15,Metwally Osama15,Meybeck Agnès15,Meyer Dan15,Meynert Alison M.15,Meysonnier Vanina15,Mezidi Mehdi15,Michelanglei Céline15,Michelet Isabelle15,Mihelis Efstathia15,Mihnovit Vladislav15,Miller Jennene15,Miranda-Maldonado Hugo15,Misnan Nor Arisah15,Mohamed Tahira Jamal15,Mohamed Nik Nur Eliza15,Moin Asma15,Molinos Elena15,Molloy Brenda15,Mone Mary15,Monteiro Agostinho15,Montes Claudia15,Montrucchio Giorgia15,Moore Shona C.15,Moore Sarah15,Morales Cely Lina15,Moro Lucia15,Morton Ben15,Motherway Catherine15,Motos Ana15,Mouquet Hugo15,Mouton Perrot Clara15,Moyet Julien15,Mudara Caroline15,Muh Ng Yong15,Muhamad Dzawani15,Mullaert Jimmy15,Müller Fredrik15,Müller Karl Erik15,Munblit Daniel15,Munshi Laveena15,Murphy Aisling15,Murray Patrick15,Murris Marlène15,Murthy Srinivas15,Musaab Himed15,Muvindi Himasha15,Myrodia Dimitra Melia15,Nadjm Behzad15,Nagpal Dave15,Nagrebetsky Alex15,Narasimhan Mangala15,Narayanan Nageswaran15,Nazerali-Maitland Alasdair15,Neant Nadège15,Neb Holger15,Nekliudov Nikita15,Nelder Matthew15,Nelwan Erni15,Neto Raul15,Neumann Emily15,Ng Pauline Yeung15,Ng Wing Yiu15,Nghi Anthony15,Nguyen Duc15,Ni Choileain Orna15,Ni Leathlobhair Niamh15,Nichol Alistair D15,Nitayavardhana Prompak15,Nonas Stephanie15,Noordin Nurul Amani Mohd15,Norharizam Nurul Faten Izzati15,Notari Alessandra15,Noursadeghi Mahdad15,Nowinski Adam15,Nseir Saad15,Nurnaningsih Nurnaningsih15,Nusantara Dwi Utomo15,Nyamankolly Elsa15,Nygaard Anders Benteson15,O Brien Fionnuala15,O Callaghan Annmarie15,Occhipinti Giovanna15,OConnor Derbrenn15,O'Donnell Max15,Ogston Tawnya15,Ogura Takayuki15,Oh Tak-Hyuk15,O'Halloran Sophie15,O'Hearn Katie15,Oldakowska Agnieszka15,Oliveira João15,Olliaro Piero L.15,Ong David S. 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Christian15,Rafael Aldo15,Rafiq Marie15,Rahardjani Mutia15,Rahman Rozanah Abd15,Rahman Ahmad Kashfi Haji Ab15,Rainieri Fernando15,Rajahram Giri Shan15,Ramakrishnan Nagarajan15,Ramalho José15,Ramli Ahmad Afiq15,Rammaert Blandine15,Ramos Grazielle Viana15,Rangappa Rajavardhan15,Ranjan Ritika15,Rapp Christophe15,Rashan Aasiyah15,Rashan Thalha15,Rasmin Menaldi15,Rätsep Indrek15,Rau Cornelius15,Ravi Tharmini15,Real Andre15,Rebaudet Stanislas15,Redl Sarah15,Reeve Brenda15,Reikvam Dag Henrik15,Reis Renato15,Rello Jordi15,Remppis Jonathan15,Remy Martine15,Ren Hongru15,Renk Hanna15,Resseguier Anne-Sophie15,Revest Matthieu15,Rewa Oleksa15,Reyes Luis Felipe15,Ribeiro Maria Ines15,Ricchiuto Antonia15,Richardson David15,Richardson Denise15,Richier Laurent15,Ridzuan Siti Nurul Atikah Ahmad15,Rios Ana L15,Rishu Asgar15,Rispal Patrick15,Risso Karine15,Rivera Nuñez Maria Angelica15,Robba Chiara15,Roberto André15,Roberts Charles15,Robertson David L.15,Robineau Olivier15,Roca Anna15,Roche-Campo Ferran15,Rodari Paola15,Rodeia Simão15,Roessler Bernhard15,Roger Claire15,Roger Pierre-Marie15,Roilides Emmanuel15,Rojek Amanda15,Roncon-Albuquerque Roberto15,Roriz Mélanie15,Rosa-Calatrava Manuel15,Rose Michael15,Rosenberger Dorothea15,Rossanese Andrea15,Rossetti Matteo15,Rossignol Patrick15,Roy Carine15,Roze Benoît15,Rusmawatiningtyas Desy15,Russell Clark D.15,Ryan Maeve15,Ryckaert Steffi15,Rygh Holten Aleksander15,Saba Isabela15,Sadat Musharaf15,Sahraei Valla15,Sakiyalak Pranya15,Salazar Leonardo15,Sales Gabriele15,Salmon Gandonniere Charlotte15,Salvator Hélène15,Sanchez Emely15,Sanchez Olivier15,Sanchez de Oliveira Kizy15,Sanchez-Miralles Angel15,Sancho-Shimizu Vanessa15,Sandhu Gyan15,Sandhu Zulfiqar15,Sandrine Pierre-François15,Santos Marlene15,Sarfo-Mensah Shirley15,Sarmento Banheiro Bruno15,Sarmiento Iam Claire E.15,Sarton Benjamine15,Satya Ankana15,Satyapriya Sree15,Satyawati Rumaisah15,Saviciute Egle15,Savvidou Parthena15,Saw Yen Tsen15,Schaffer Justin15,Schermer Tjard15,Scherpereel Arnaud15,Schneider Marion15,Schwameis Michael15,Schwartz Gary15,Scott Janet T.15,Scott-Brown James15,Sedillot Nicholas15,Seitz Tamara15,Selvarajoo Mageswari15,Semple Malcolm G.15,Senian Rasidah Bt15,Senneville Eric15,Sepulveda Claudia15,Sequeira Filipa15,Sequeira Tânia15,Serpa Neto Ary15,Serrano Balazote Pablo15,Shadowitz Ellen15,Shahidan Syamin Asyraf15,Shankar Anuraj15,Sharjeel Shaikh15,Sharma Pratima15,Shaw Catherine A.15,Shaw Victoria15,Sheenan John Robert15,Shetty Rohan15,Shetty Dr. Rajesh Mohan15,Shiekh Mohiuddin15,Shime Nobuaki15,Shimizu Hiroaki15,Shimizu Keiki15,Shrapnel Sally15,Shum Hoi Ping15,Si Mohammed Nassima15,Siang Ng Yong15,Sibiude Jeanne15,Sibounheuang Bountoy15,Siddiqui Atif15,Sigfrid Louise15,Sillah Fatoumata15,Sillaots Piret15,Silva Catarina15,Silva Rogério15,Silva Maria Joao15,Sim Lim Heng Benedict15,Sin Wai Ching15,Sinatti Dario15,Singh Punam15,Singh Mahendra15,Sitompul Pompini Agustina15,Sivam Karisha15,Skogen Vegard15,Smith Sue15,Smood Benjamin15,Smyth Coilin15,Snacken Morgane15,So Dominic15,Soh Tze Vee15,Solberg Lene Bergendal15,Solomon Joshua15,Solomon Tom15,Somers Emily15,Sommet Agnès15,Song Rima15,Song Myung Jin15,Song Tae15,Song Chia Jack15,Søraas Arne15,Sotto Albert15,Soum Edouard15,Sousa Marta15,Sousa Ana Chora15,Sousa Uva Maria15,Souza-Dantas Vicente15,Sperry Alexandra15,Spinuzza Elisabetta15,Sri Darshana B. P. Sanka Ruwan15,Sriskandan Shiranee15,Stabler Sarah15,Staudinger Thomas15,Stecher Stephanie-Susanne15,Steinsvik Trude15,Stienstra Ymkje15,Stiksrud Birgitte15,Stolz Eva15,Stone Amy15,Streinu-Cercel Adrian15,Streinu-Cercel Anca15,Stuart Ami15,Stuart David15,Su Richa15,Subekti Decy15,Suen Gabriel15,Suen Jacky Y.15,Sukumar Prasanth15,Sultana Asfia15,Summers Charlotte15,Supic Dubravka15,Suppiah Deepashankari15,Surovcová Magdalena15,Suwarti Atie15,Svistunov Andrey15,Syahrin Sarah15,Syrigos Konstantinos15,Sztajnbok Jaques15,Szuldrzynski Konstanty15,Tabrizi Shirin15,Taccone Fabio S.15,Tagherset Lysa15,Taib Shahdattul Mawarni15,Talarek Ewa15,Taleb Sara15,Talsma Jelmer15,Tamisier Renaud15,Tampubolon Maria Lawrensia15,Tan Kim Keat15,Tan Yan Chyi15,Tanaka Hiroyuki15,Tanaka Taku15,Taniguchi Hayato15,Tardivon Coralie15,Tattevin Pierre15,Taufik M Azhari15,Tawfik Hassan15,Tee Tze Yuan15,Teixeira João15,Tejada Sofia15,Tellier Marie-Capucine15,Teoh Sze Kye15,Teotonio Vanessa15,Téoulé François15,Terrier Olivier15,Terzi Nicolas15,Tessier-Grenier Hubert15,Tey Adrian15,Thabit Alif Adlan Mohd15,Tham Zhang Duan15,Thangavelu Suvintheran15,Theron Elmi15,Thibault Vincent15,Thiberville Simon-Djamel15,Thill Benoît15,Thirumanickam Jananee15,Thompson Shaun15,Thompson Niamh15,Thomson David15,Thomson Emma C.15,Thorpe Mathew15,Thurai Surain Raaj Thanga15,Thwaites Ryan S.15,Tierney Paul15,Tieroshyn Vadim15,Timashev Peter S15,Timsit Jean-François15,Tissot Noémie15,Toal Fiona15,Toh Jordan Zhien Yang15,Toki Maria15,Tonby Kristian15,Tonnii Sia Loong15,Torre Marta15,Torres Margarida15,Torres Antoni15,Torres Santos-Olmo Rosario Maria15,Torres-Zevallos Hernando15,Towers Michael15,Trapani Tony15,Tromeur Cécile15,Trontzas Ioannis15,Trouillon Tiffany15,Truong Jeanne15,Tual Christelle15,Tubiana Sarah15,Tuite Helen15,Turgeon Alexis F.15,Turmel Jean-Marie15,Turtle Lance C.W.15,Tveita Anders15,Twardowski Pawel15,Uchiyama Makoto15,Udayanga PG Ishara15,Udy Andrew15,Ullrich Roman15,Uribe Alberto15,Usman Asad15,Uyeki Timothy M.15,Vaillant Michel15,Vajdovics Cristinava15,Valentini Piero15,Val-Flores Luís15,Van de Velde Stijn15,van den Berge Marcel15,van der Feltz Machteld15,van der Palen Job15,van der Valk Paul15,Van Der Vekens Nicky15,Van der Voort Peter15,Van Der Werf Sylvie15,van Gulik Laura15,Van Hattem Jarne15,van Netten Carolien15,van Someren Gréve Frank15,van Veen Ilonka15,Van Willigen Hugo15,Vanel Noémie15,Vanoverschelde Henk15,Varrone Michael15,Vasudayan Shoban Raj15,Vauchy Charline15,Vecham Pavan Kumar15,Veeran Shaminee15,Veislinger Aurélie15,Vencken Sebastian15,Ventura Sara15,Verbon Annelies15,Vidal José Ernesto15,Vieira César15,Villar Judit15,Villeneuve Pierre-Marc15,Villoldo Andrea15,Vishwanathan Gayatri15,Visseaux Benoit15,Visser Hannah15,Vitiello Chiara15,Vongsouvath Manivanh15,Vonkeman Harald15,Vuotto Fanny15,Wahab Noor Hidayu15,Wahab Suhaila Abdul15,Wahid Nadirah Abdul15,Wainstein Marina15,Walsh Laura15,Wang Chih-Hsien15,Webb Steve15,Wei Jia15,Weil Katharina15,Wen Tan Pei15,Wesselius Sanne15,West T. Eoin15,Wham Murray15,Whelan Bryan15,White Nicole15,Wicky Paul Henri15,Wiedemann Aurélie15,Wijaya Surya Otto15,Wille Keith15,Willems Sue15,Williams Bailey15,Williams Virginie15,Williams Patricia J15,Wittman Jessica15,Wong Calvin15,Wong Xin Ci15,Wong Yew Sing15,Wong Teck Fung15,Wright Natalie15,Xian Lim Saio15,Xynogalas Ioannis15,Yakop Siti Rohani Binti Mohd15,Yamazaki Masaki15,Yarad Elizabeth15,Yazdanpanah Yazdan15,Yee Liang Hing Nicholas15,Yelnik Cécile15,Yeoh Chian Hui15,Yerkovich Stephanie15,Yiaye Touxiong15,Yokoyama Toshiki15,Yonis Hodane15,Yousif Obada15,Yuliarto Saptadi15,Zaaqoq Akram15,Zabbe Marion15,Zacharowski Kai15,Zahid Masliza15,Zahran Maram15,Zaidan Nor Zaila Binti15,Zambon Maria15,Zambrano Miguel15,Zanella Alberto15,Zawadka Konrad15,Zaynah Nurul15,Zayyad Hiba15,Zoufaly Alexander15,Zucman David15,

Affiliation:

1. Université de Sherbrooke, Sherbrooke, Quebec, Canada

2. ISARIC, Pandemic Sciences Institute, University of Oxford, Oxford, United Kingdom

3. Department of Critical Care Medicine, Apollo Main Hospital, Chennai, India

4. The George Institute for Global Health, New Delhi, India

5. Department of Epidemiology and Preventive Medicine, Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), Monash University, Melbourne, Victoria, Australia

6. Alfred Hospital, Melbourne, Victoria, Australia

7. Medical Research Council Unit The Gambia at London School of Hygiene and Tropical Medicine, Fajara, The Gambia

8. Franciscus Gasthuis & Vlietland, Rotterdam, the Netherlands

9. Erasmus MC-University Medical Center, Rotterdam, the Netherlands

10. Department of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

11. Department of Intensive Care Medicine, Multidisciplinary Intensive Care Research Organization (MICRO), St James’s Hospital Dublin, Leinster, Ireland

12. Department of Infectious Diseases I, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

13. National Institute for Infectious Diseases Prof Dr Matei Balș, Bucharest, Romania

14. Department of Anaesthesiology and Intensive Care Medicine, Division of Critical Care and Emergencies, Rikshospitalet Medical Centre, Oslo University Hospital, Oslo, Norway

15. for the ISARIC Clinical Characterisation Group

Abstract

ImportanceResearch diversity and representativeness are paramount in building trust, generating valid biomedical knowledge, and possibly in implementing clinical guidelines.ObjectivesTo compare variations over time and across World Health Organization (WHO) geographic regions of corticosteroid use for treatment of severe COVID-19; secondary objectives were to evaluate the association between the timing of publication of the RECOVERY (Randomised Evaluation of COVID-19 Therapy) trial (June 2020) and the WHO guidelines for corticosteroids (September 2020) and the temporal trends observed in corticosteroid use by region and to describe the geographic distribution of the recruitment in clinical trials that informed the WHO recommendation.Design, Setting, and ParticipantsThis prospective cohort study of 434 851 patients was conducted between January 31, 2020, and September 2, 2022, in 63 countries worldwide. The data were collected under the auspices of the International Severe Acute Respiratory and Emerging Infections Consortium (ISARIC)–WHO Clinical Characterisation Protocol for Severe Emerging Infections. Analyses were restricted to patients hospitalized for severe COVID-19 (a subset of the ISARIC data set).ExposureCorticosteroid use as reported to the ISARIC-WHO Clinical Characterisation Protocol for Severe Emerging Infections.Main Outcomes and MeasuresNumber and percentage of patients hospitalized with severe COVID-19 who received corticosteroids by time period and by WHO geographic region.ResultsAmong 434 851 patients with confirmed severe or critical COVID-19 for whom receipt of corticosteroids could be ascertained (median [IQR] age, 61.0 [48.0-74.0] years; 53.0% male), 174 307 (40.1%) received corticosteroids during the study period. Of the participants in clinical trials that informed the guideline, 91.6% were recruited from the United Kingdom. In all regions, corticosteroid use for severe COVID-19 increased, but this increase corresponded to the timing of the RECOVERY trial (time-interruption coefficient 1.0 [95% CI, 0.9-1.2]) and WHO guideline (time-interruption coefficient 1.9 [95% CI, 1.7-2.0]) publications only in Europe. At the end of the study period, corticosteroid use for treatment of severe COVID-19 was highest in the Americas (5421 of 6095 [88.9%]; 95% CI, 87.7-90.2) and lowest in Africa (31 588 of 185 191 [17.1%]; 95% CI, 16.8-17.3).Conclusions and RelevanceThe results of this cohort study showed that implementation of the guidelines for use of corticosteroids in the treatment of severe COVID-19 varied geographically. Uptake of corticosteroid treatment was lower in regions with limited clinical trial involvement. Improving research diversity and representativeness may facilitate timely knowledge uptake and guideline implementation.

Publisher

American Medical Association (AMA)

Subject

General Medicine

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