Colorectal Cancer Stage at Diagnosis Before vs During the COVID-19 Pandemic in Italy-Reference-Cited by-同舟云学术

Colorectal Cancer Stage at Diagnosis Before vs During the COVID-19 Pandemic in Italy

Published:2022-11-21 Issue:11 Volume:5 Page:e2243119
ISSN:2574-3805
Container-title:JAMA Network Open
language:en
Short-container-title:JAMA Netw Open

Author:

Rottoli Matteo¹²,Gori Alice¹²,Pellino Gianluca³⁴,Flacco Maria Elena⁵,Martellucci Cecilia⁵,Spinelli Antonino⁶⁷,Poggioli Gilberto¹²,Romano Angela⁸,Belvedere Angela⁸,Lanci Lanci Antonio⁸,Parlanti Daniele⁸,Vago Gabriele⁸,Pezzuto Paola⁸,Canavese Anna⁸,Dajti Gerti⁸,Cardelli Stefano⁸,Catalioto Caterina⁸,Russo Iris S⁸,Violante Tommaso⁸,Morezzi Daniele⁸,Maurino Ludovica⁸,Filippone Eleonora⁸,Cuicchi Dajana⁸,Bernante Paolo⁸,Jovine Elio⁸,Lombardi Raffaele⁸,Masetti Michele⁸,Cipressi Chiara⁸,Offi Maria F⁸,Larotonda Cristina⁸,Puglisi Silvana B⁸,Barbosa Augusto⁸,Vaiana Roberto⁸,Bianchi Paolo M⁸,Tonti Carlo⁸,Codignola Claudio⁸,Zorcolo Luigi⁸,Restivo Angelo⁸,Deidda Simona⁸,Marchetti Marcello E⁸,Ippolito Luca⁸,Spolverato Gaya⁸,Pucciarelli Salvatore⁸,Marchegiani Francesco⁸,Ghio Giacomo⁸,Zagolin Gaya⁸,Glavas Dajana⁸,Tomassi Monica⁸,Rosati Riccardo⁸,Elmore Ugo⁸,Gozzini Lorenzo⁸,Calef Riccardo⁸,Puccetti Francesco⁸,Cossu Andrea⁸,Vignali Andrea⁸,Morino Mario⁸,Allaix Marco E⁸,Cannata Gaspare⁸,Lombardi Erica⁸,Ammirati Carlo A⁸,Piceni Chiara⁸,Buccianti Piero⁸,Balestri Riccardo⁸,Puccini Marco⁸,Pezzati Daniele⁸,d'Ischia Roberto⁸,Asta Vito F⁸,Sargenti Benedetta⁸,Taddei Giacomo⁸,Bonari Federica⁸,Boni Giulia⁸,Ferrero Alessandro⁸,Mineccia Michela⁸,Gonella Federica⁸,Palisi Marco⁸,Danese Francesco⁸,Cherubini Valeria⁸,Perotti Serena⁸,Carvello Michele⁸,Carbone Fabio⁸,Luberto Antonio⁸,Calafiore Eleonora⁸,De Lucia Francesca⁸,Sacchi Matteo⁸,Sasia Diego⁸,Giuffrida Maria C⁸,Ballauri Edoardo⁸,Cardile Mathieu⁸,Armentano Serena⁸,Beltrami Elsa⁸,Preve Gabriele⁸,Vercellone Barbara⁸,Mozzon Marta⁸,Folliero Cristina⁸,Lirusso Chiara⁸,Vecchiato Massimo⁸,Ziccarelli Antonio⁸,Gattesco Davide⁸,Moretti Luisa⁸,Crestale Sara⁸,Banchini Filippo⁸,Capelli Patrizio⁸,Romboli Andrea⁸,Palmieri Gerardo⁸,Conti Luigi⁸,Rizzi Nicholas⁸,Bonfili Deborah⁸,de Manzini Nicolò⁸,Germani Paola⁸,Osenda Edoardo⁸,Cortinovis Sara⁸,Giunta Carlotta⁸,Fracon Stefano⁸,Abdallah Hussein⁸,Bogoni Selene⁸,Portolani Nazario⁸,Nascimbeni Riccardo⁸,Molfino Sarah⁸,Tiberio Guido A M⁸,Garosio Ilenia⁸,Lamperti Giulia⁸,Rigosa Diego⁸,Ercolani Giorgio⁸,Solaini Leonardo⁸,Cavaliere Davide⁸,Avanzolini Andrea⁸,D'Acapito Fabrizio⁸,Chiarella Leonardo L⁸,Di Pietrantonio Daniela⁸,Annunziata Domenico⁸,Piccolo Roberta⁸,Sorrentino Mario⁸,Pansini Mauro⁸,Cojutti Alessandro⁸,Graziano Michele⁸,Callegari Francesco⁸,Balzarotti Laura⁸,Dameno Vitale R⁸,Cattaneo Antonio⁸,Santolamazza Giuliano⁸,Altieri Caterina⁸,Magarini Riccardo⁸,Pietrabissa Andrea⁸,Dominioni Tommaso⁸,Pugliese Luigi⁸,Peri Andrea⁸,Botti Marta⁸,Salvetti Francesco⁸,Cassinotti Elisa⁸,Baldari Ludovica⁸,Boni Luigi⁸,Messina Valentina⁸,D'Abrosca Vera⁸,Cianci Pasquale⁸,Tumolo Rocco⁸,Gattulli Domenico⁸,Restini Enrico⁸,Minafra Marina⁸,Sederino Maria G⁸,Bottalico Bernardino⁸,Pilati Pierluigi⁸,Franzato Boris⁸,Mattara Genny⁸,De Simoni Ottavia⁸,Barina Andrea⁸,Tonello Marco⁸,Muratore Andrea⁸,Calabrò Marcello⁸,Federico Pipitone Nicoletta S⁸,Cuzzola Bruno⁸,Herranz van Nood Elena⁸,Passuello Nicola⁸,Frasson Alvise⁸,Mammano Enzo⁸,Faccio Luca⁸,Vittadello Fabrizio⁸,Bressan Alice⁸,Sarzo Giacomo⁸,Tamini Nicolò⁸,Oldani Massimo⁸,Cigagna Luca⁸,Carissimi Francesca⁸,De Carlo Giulia⁸,Baccalini Edoardo⁸,Nespoli Luca⁸,Giordano Alessio⁸,Cantafio Stefano⁸,Grifoni Lucrezia⁸,Matani Davide⁸,Livi Serena⁸,Delogu Daniele⁸,Scognamillo Fabrizio⁸,Marrosu Antonio⁸,Guerrini Luca⁸,Ugolini Giampaolo⁸,Ghignone Federico⁸,Frascaroli Giacomo⁸,Albertini Nicola⁸,Zattoni Davide⁸,Taffurelli Giovanni⁸,Montroni Isacco⁸,Colombo Francesco⁸,Danelli Piergiorgio⁸,Bondurri Andrea⁸,Maffioli Anna⁸,Bonomi Alessandro⁸,Pezzoli Isabella⁸,Cammarata Francesco⁸,Goletti Orlando⁸,Molteni Mattia⁸,Assisi Alberto⁸,Quartierini Giorgio⁸,Da Lio Corrado⁸,Verdi Daunia⁸,Mondi Isabella⁸,Peluso Claudia⁸,Macchi Lorenzo⁸,Tanzanu Marta⁸,Zanzi Federico⁸,Pellegrini Sara⁸,Andreuccetti Jacopo⁸,D'Alessio Rossella⁸,Pignata Giusto⁸,De Capua Michele⁸,Canfora Ilaria⁸,Ottaviani Luca⁸,Lepiane Pasquale⁸,Balla Andrea⁸,De Carlo Antonio⁸,Saraceno Federica⁸,Scaramuzzo Rosa⁸,Guida Anna⁸,Aguzzi Daniele⁸,Bellora Paolo⁸,Gentilli Sergio⁸,Monni Manuela⁸,Nikaj Herald⁸,Cillara Nicola⁸,Cannavera Alessandro⁸,Deserra Antonello⁸,Margiani Carla⁸,Cabula Roberta⁸,Dettori Manuela⁸,Gramignano Giulia⁸,Lezoche Giovanni⁸,Ortenzi Monica⁸,Orlandoni Elena S⁸,Curzi Federica⁸,Vitali Francesca⁸,Capomagi Perla⁸,Palmieri Miriam⁸,Giuffrida Mario⁸,Del Rio Paolo⁸,Bonati Elena⁸,Loderer Tommaso⁸,Cozzani Federico⁸,Rossini Matteo⁸,Agnesi Stefano⁸,Capolupo Gabriella T⁸,Caricato Marco⁸,Carannante Filippo⁸,Mascianà Gianluca⁸,Marrelli Martina⁸,Miacci Valentina⁸,Lauricella Sara⁸,Tonini Valeria⁸,Cervellera Maurizio⁸,Pisconti Salvatore⁸,Lozito Concetta⁸,Shahu Juliana⁸,Mongelli Claudia⁸,Morelli Giulia⁸,Sartarelli Lodovico⁸,Sica Giuseppe S⁸,Siragusa Leandro⁸,Bagaglini Giulia⁸,Sensi Bruno⁸,Guida Andrea M⁸,Franceschilli Marzia⁸,Vinci Danilo⁸,Taddei Antonio⁸,Risaliti Matteo⁸,Bartolini Ilenia⁸,Ringressi Maria N⁸,Tirloni Luca⁸,Laface Letizia⁸,Abate Emmanuele⁸,Casati Massimiliano⁸,Gobbi Pietro⁸,Opocher Enrico⁸,Mariani Nicolò M⁸,Pisani Ceretti Andrea⁸,Giovenzana Marco⁸,Giuliani Beatrice⁸,Sironi Martina⁸,Grossi Ugo⁸,Zanus Giacomo⁸,Aniello Santoro Giulio⁸,Brizzolari Marco⁸,De Leo Eugenio⁸,Novello Simone⁸,Aquilino Krizia⁸,Milardi Francesco⁸,Olmi Stefano⁸,Uccelli Matteo⁸,Bonaldi Marta⁸,Cesana Giovanni C⁸,Bindi Marco⁸,Galleano Raffaele⁸,Langone Antonio⁸,Botto Massimiliano⁸,Franceschi Angelo⁸,Gambino Elena⁸,Ronconi Maurizio⁸,Casiraghi Silvia⁸,Casole Giovanni⁸,Ciulla Salvatore L⁸,Terrosu Giovanni⁸,Calandra Sergio⁸,Scarpa Edoardo⁸,Cherchi Vittorio⁸,Calini Giacomo⁸,Martinuzzo Lisa⁸,Clocchiatti Lucrezia⁸,Muschitiello Davide⁸,Romanzi Andrea⁸,Vignati Barbara⁸,Vannelli Alberto⁸,Scolaro Roberta⁸,Milanesi Maria⁸,Rossi Fabrizio⁸,Canonico Giuseppe⁸,Anastasi Alessandro⁸,Nelli Tommaso⁸,Barlettai Marco⁸,Fratarcangeli Riccardo⁸,Di Martino Carmela⁸,Damigella Andrea⁸,Adinolfi Elvira⁸,Birindelli Arianna⁸,Taglietti Lucio⁸,Dester Sara E⁸,Fleres Francesco⁸,Cucinotta Eugenio⁸,Viscosi Francesca⁸,Biondo Santino Antonio⁸,Badessi Giorgio⁸,Catarsini Nivia⁸,Mazzeo Carmelo⁸,Rega Daniela⁸,Delrio Paolo⁸,Cervone Carmela⁸,Aversano Alessia⁸,De Franciscis Silvia⁸,Di Marzo Massimiliano⁸,Marra Bruno⁸,Pace Ugo⁸,Amato Antonio⁸,Batistotti Paola⁸,Mina Elisa⁸,Serventi Alberto⁸,Lapolla Pierfrancesco⁸,Mingoli Andrea⁸,Sapienza Paolo⁸,Brachini Gioia⁸,Cirillo Bruno⁸,Fiori Enrico⁸,Crocetti Daniele⁸,Clementi Ilaria⁸,Martines Gennaro⁸,Picciariello Arcangelo⁸,Tomasicchio Giovanni⁸,Dibra Rigers⁸,Trigiante Giuseppe⁸,Rinaldi Marcella⁸,Lantone Giuliano⁸,Porcu Alberto⁸,Perra Teresa⁸,Scanu Antonio M⁸,Feo Claudio F⁸,Fancellu Alessandro⁸,Cossu Maria L⁸,Ginesu Giorgio C⁸,Patriti Alberto⁸,Coletta Diego⁸,Petrelli Filippo⁸,Greco Paola A⁸,Spadoni Claudia⁸,Cassiani Giovanna⁸,Bianchini Federica⁸,Arganini Marco⁸,Bianchini Matteo⁸,Perotti Bruno⁸,Palmeri Matteo⁸,Scabini Stefano⁸,Deiana Selene⁸,Carganico Giacomo⁸,Pertile Davide⁸,Soriero Domenico⁸,Fioravanti Emanuela⁸,Sperotto Beatrice⁸,Nardo Bruno⁸,Paglione Daniele⁸,Crocco Veronica⁸,Doni Marco⁸,Osso Mariasara⁸,Perri Roberto⁸,Sampietro Gianluca M⁸,Corbellini Carlo⁸,Lorusso Leonardo⁸,Manzo Carlo A⁸,Cigognini Maria⁸,Baldi Caterina⁸,Palomba Giuseppe⁸,Aprea Giovanni⁸,Capuano Marianna⁸,Basile Raffaele⁸,Tutino Roberta⁸,Massani Marco⁸,Marinelli Laura⁸,Canitano Nicola⁸,Pilia Tiziana⁸,Podda Mauro⁸,Pisanu Adolfo⁸,Murzi Valentina⁸,Incani Silvia⁸,Frongia Federica⁸,Esposito Giuseppe⁸,Luglio Gaetano⁸,Tropeano Francesca P⁸,Pagano Gianluca⁸,Spina Eduardo⁸,De Simone Giuseppe⁸,Cricrì Michele⁸,Catena Fausto⁸,Vallicelli Carlo⁸,Zanini Nicola⁸,Ronconi Diana⁸,Favi Francesco⁸,Mazzucchelli Carlo⁸,Convertini Girolamo⁸,Vincenti Leonardo⁸,Andriola Valeria⁸,Bizzoca Cinzia⁸,Feo Carlo V⁸,Fabbri Nicolò⁸,Fazzin Marta⁸,Pesce Antonio⁸,Gennari Silvia⁸,Torchiaro Marco⁸,Severi Silvia⁸,Frontali Alice⁸,Bracchetti Greta⁸,Granieri Stefano⁸,Cotsoglou Christian⁸,Carlini Massimo⁸,Lisi Giorgio⁸,Spoletini Domenico⁸,Mastrangeli Maria R⁸,Campanelli Michela⁸,Manigrasso Michele⁸,Milone Marco⁸,De Palma Giovanni D⁸,Vertaldi Sara⁸,Chini Alessia⁸,Maione Francesco⁸,Marello Alessandra⁸,Selvaggi Francesco⁸,Sciaudone Guido⁸,Selvaggi Lucio⁸,Menegon Tasselli Francesco⁸,Fuschillo Giacomo⁸,Oddis Lidia⁸,Grande Simona⁸,Grande Michele⁸,Ascanelli Simona⁸,Chimisso Laura⁸,Aisoni Filippo⁸,Rossin Eleonora⁸,Pepe Francesco⁸,Marchetti Francesco⁸,Picardi Biagio⁸,Rossi Stefano⁸,Rossi Del Monte Simone⁸,Picarelli Matteo⁸,Muttillo Irnerio A⁸,Ratto Carlo⁸,Marra Angelo A⁸,Parello Angelo⁸,Litta Francesco⁸,Campennì Paola⁸,De Simone Veronica⁸,Pata Francesco⁸,Riboni Cristiana⁸,Rausa Emanuele⁸,Celentano Valerio⁸,

Affiliation:

1. Surgery of the Alimentary Tract, IRCCS Azienda Ospedaliero–Universitaria di Bologna, Bologna, Italy

2. Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy

3. Department of Advanced Medical and Surgical Sciences, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy

4. Colorectal Surgery, University Hospital Vall d’Hebron, Barcelona, Spain

5. Department of Environmental and Preventive Sciences, University of Ferrara, Ferrara, Italy

6. Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy

7. Colorectal Surgery, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy

8. for the COVID–Colorectal Cancer (CRC) Study Group

Abstract

ImportanceDelays in screening programs and the reluctance of patients to seek medical attention because of the outbreak of SARS-CoV-2 could be associated with the risk of more advanced colorectal cancers at diagnosis.ObjectiveTo evaluate whether the SARS-CoV-2 pandemic was associated with more advanced oncologic stage and change in clinical presentation for patients with colorectal cancer.Design, Setting, and ParticipantsThis retrospective, multicenter cohort study included all 17 938 adult patients who underwent surgery for colorectal cancer from March 1, 2020, to December 31, 2021 (pandemic period), and from January 1, 2018, to February 29, 2020 (prepandemic period), in 81 participating centers in Italy, including tertiary centers and community hospitals. Follow-up was 30 days from surgery.ExposuresAny type of surgical procedure for colorectal cancer, including explorative surgery, palliative procedures, and atypical or segmental resections.Main Outcomes and MeasuresThe primary outcome was advanced stage of colorectal cancer at diagnosis. Secondary outcomes were distant metastasis, T4 stage, aggressive biology (defined as cancer with at least 1 of the following characteristics: signet ring cells, mucinous tumor, budding, lymphovascular invasion, perineural invasion, and lymphangitis), stenotic lesion, emergency surgery, and palliative surgery. The independent association between the pandemic period and the outcomes was assessed using multivariate random-effects logistic regression, with hospital as the cluster variable.ResultsA total of 17 938 patients (10 007 men [55.8%]; mean [SD] age, 70.6 [12.2] years) underwent surgery for colorectal cancer: 7796 (43.5%) during the pandemic period and 10 142 (56.5%) during the prepandemic period. Logistic regression indicated that the pandemic period was significantly associated with an increased rate of advanced-stage colorectal cancer (odds ratio [OR], 1.07; 95% CI, 1.01-1.13; P = .03), aggressive biology (OR, 1.32; 95% CI, 1.15-1.53; P &lt; .001), and stenotic lesions (OR, 1.15; 95% CI, 1.01-1.31; P = .03).Conclusions and RelevanceThis cohort study suggests a significant association between the SARS-CoV-2 pandemic and the risk of a more advanced oncologic stage at diagnosis among patients undergoing surgery for colorectal cancer and might indicate a potential reduction of survival for these patients.

Publisher

American Medical Association (AMA)

Subject

General Medicine

Link

https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2798828/rottoli_2022_oi_221212_1668176867.11122.pdf

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