Polygenic Risk Scores for Breast Cancer—Can They Deliver on the Promise of Precision Medicine?
Author:
Affiliation:
1. Basser Center for BRCA, Perelman Center for Advanced Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
Publisher
American Medical Association (AMA)
Subject
General Medicine
Link
https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2782671/shah_2021_ic_210155_1627404505.67106.pdf
Reference8 articles.
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2. Evaluating the utility of polygenic risk scores in identifying high-risk individuals for eight common cancers.;Jia;JNCI Cancer Spectr,2020
3. The WISDOM personalized breast cancer screening trial: simulation study to assess potential bias and analytic approaches.;Eklund;JNCI Cancer Spectr,2019
4. CanRisk tool—a web interface for the prediction of breast and ovarian cancer risk and the likelihood of carrying genetic pathogenic variants.;Carver;Cancer Epidemiol Biomarkers Prev,2021
5. Integrating clinical and polygenic factors to predict breast cancer risk in women undergoing genetic testing.;Hughes;JCO Precis Oncol,2021
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