Body Mass Index and Risk of Colorectal Cancer Incidence and Mortality in Asia-Reference-Cited by-同舟云学术

Body Mass Index and Risk of Colorectal Cancer Incidence and Mortality in Asia

Published:2024-08-28 Issue:8 Volume:7 Page:e2429494
ISSN:2574-3805
Container-title:JAMA Network Open
language:en
Short-container-title:JAMA Netw Open

Author:

Paragomi Pedram¹,Zhang Zhongjie²,Abe Sarah Krull³,Islam Md. Rashedul³⁴,Rahman Md. Shafiur³⁵,Saito Eiko⁶,Shu Xiao-Ou⁷,Dabo Bashir⁸,Pham Yen Thi-Hai¹²,Chen Yu⁹¹⁰,Gao Yu-Tang¹¹¹²,Koh Woon-Puay¹³¹⁴,Sawada Norie¹⁵,Malekzadeh Reza¹⁶,Sakata Ritsu¹⁷,Hozawa Atsushi¹⁸,Kim Jeongseon¹⁹,Kanemura Seiki¹⁸,Nagata Chisato²⁰,You San-Lin²¹,Ito Hidemi²²,Park Sue K.²³,Yuan Jian-Min¹²,Pan Wen-Harn²⁴²⁵,Wen Wanqing⁷,Wang Renwei¹,Cai Hui¹⁸,Tsugane Shoichiro¹⁵,Pourshams Akram¹⁶,Sugawara Yumi¹⁸,Wada Keiko²⁰,Chen Chien-Jen²⁶,Oze Isao²⁷,Shin Aesun²³²⁸,Ahsan Habibul²⁹,Boffetta Paolo³⁰³¹,Chia Kee Seng³²,Matsuo Keitaro²⁷³³,Qiao You-Lin³⁴,Rothman Nathaniel³⁵,Zheng Wei⁷,Inoue Manami³,Kang Daehee²³,Luu Hung N.¹²

Affiliation:

1. Division of Cancer Control and Population Sciences, University of Pittsburgh Medical Center Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania

2. Department of Epidemiology, University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania

3. Division of Prevention, National Cancer Center Institute for Cancer Control, Tokyo, Japan

4. Department of Global Health Policy, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

5. Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan

6. Institute for Global Health Policy Research, National Center for Global Health and Medicine, Tokyo, Japan

7. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee

8. Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa

9. Department of Population Health, New York University Grossman School of Medicine, New York

10. Division of Environmental Medicine, New York University Grossman School of Medicine, New York

11. Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China

12. Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

13. Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

14. Singapore Institute for Clinical Sciences, Agency for Science Technology and Research, Singapore

15. Division of Cohort Research, National Cancer Center Institute for Cancer Control, Tokyo, Japan

16. Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran

17. Radiation Effects Research Foundation, Hiroshima, Japan

18. Tohoku University Graduate School of Medicine, Sendai, Japan

19. Graduate School of Science and Policy, National Cancer Center, Gyeonggi-Do, Republic of Korea

20. Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, Gifu, Japan

21. School of Medicine and Big Data Research Center, Fu Jen Catholic University, New Taipei City, Taiwan

22. Division of Cancer Information and Control, Department of Preventive Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan

23. Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea

24. Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan

25. Institute of Population Health Sciences, National Health Research Institutes, Miaoli County, Taiwan

26. Genomics Research Center, Academia Sinica, Taipei, Taiwan

27. Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan

28. Cancer Research Institute, Seoul National University, Seoul, Republic of Korea

29. Department of Public Health Sciences, The University of Chicago, Chicago, Illinois

30. Stony Brook Cancer Center, Stony Brook University, Stony Brook, New York

31. Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy

32. Saw Swee Hock School of Public Health, National University of Singapore, Singapore

33. Department of Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan

34. Center for Global Health, School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

35. Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, Bethesda, Maryland

Abstract

ImportanceThe global burden of obesity is increasing, as are colorectal cancer (CRC) incidence and mortality.ObjectivesTo assess the association between body mass index (BMI) and risks of incident CRC and CRC-related death in the Asian population.Design, Setting, and ParticipantsThis cohort study includes data pooled from 17 prospective cohort studies included in The Asia Cohort Consortium. Cohort enrollment was conducted from January 1, 1984, to December 31, 2002. Median follow-up time was 15.2 years (IQR, 12.1-19.2 years). Data were analyzed from January 15, 2023, through January 15, 2024.ExposureBody mass index, calculated as weight in kilograms divided by height in meters squared.Main Outcomes and MeasuresThe primary outcomes were CRC incidence and CRC-related mortality. The risk of events is reported as adjusted hazard ratios (AHRs) and 95% CIs for incident CRC and death from CRC using the Cox proportional hazards regression model.ResultsTo assess the risk of incident CRC, 619 981 participants (mean [SD] age, 53.8 [10.1] years; 52.0% female; 11 900 diagnosed incident CRC cases) were included in the study, and to assess CRC-related mortality, 650 195 participants (mean [SD] age, 53.5 [10.2] years; 51.9% female; 4550 identified CRC deaths) were included in the study. A positive association between BMI and risk of CRC was observed among participants with a BMI greater than 25.0 to 27.5 (AHR, 1.09 [95% CI, 1.03-1.16]), greater than 27.5 to 30.0 (AHR, 1.19 [95% CI, 1.11-1.29]), and greater than 30.0 (AHR, 1.32 [95% CI, 1.19-1.46]) compared with those with a BMI greater than 23.0 to 25.0 (P &lt; .001 for trend), and BMI was associated with a greater increase in risk for colon cancer than for rectal cancer. A similar association between BMI and CRC-related death risk was observed among participants with a BMI greater than 27.5 (BMI &gt;27.5-30.0: AHR, 1.18 [95% CI, 1.04-1.34]; BMI &gt;30.0: AHR, 1.38 [95% CI, 1.18-1.62]; P &lt; .001 for trend) and was present among men with a BMI greater than 30.0 (AHR, 1.87 [95% CI, 1.49-2.34]; P &lt; .001 for trend) but not among women (P = .15 for trend) (P = .02 for heterogeneity).Conclusions and RelevanceIn this cohort study that included a pooled analysis of 17 cohort studies comprising participants across Asia, a positive association between BMI and CRC incidence and related mortality was found. The risk was greater among men and participants with colon cancer. These findings may have implications to better understand the burden of obesity on CRC incidence and related deaths in the Asian population.

Publisher

American Medical Association (AMA)

Link

https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2822908/paragomi_2024_oi_240893_1724265065.13374.pdf

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