Misleading Reporting (Spin) in Noninferiority Randomized Clinical Trials in Oncology With Statistically Not Significant Results

Author:

Ito Chiyo12,Hashimoto Atsushi2,Uemura Kohei3,Oba Koji34

Affiliation:

1. Graduate School of Interdisciplinary Information Studies, The University of Tokyo, Tokyo, Japan

2. Clinical and Translational Research Center, Niigata University Medical and Dental Hospital, Niigata, Japan

3. Interfaculty Initiative in Information Studies, The University of Tokyo, Tokyo, Japan

4. Department of Biostatistics, School of Public Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

Publisher

American Medical Association (AMA)

Subject

General Medicine

Reference86 articles.

1. New evidence pyramid.;Murad;Evid Based Med,2016

2. The scientific impact of positive and negative phase 3 cancer clinical trials.;Unger;JAMA Oncol,2016

3. “Spin” in scientific writing: scientific mischief and legal jeopardy.;Fletcher;Med Law,2007

4. Reporting and interpretation of randomized controlled trials with statistically nonsignificant results for primary outcomes.;Boutron;JAMA,2010

5. Evaluation of spin in oncology clinical trials.;Wayant;Crit Rev Oncol Hematol,2019

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