Efficacy and Safety of Upadacitinib vs Dupilumab in Adults With Moderate-to-Severe Atopic Dermatitis

Author:

Blauvelt Andrew1,Teixeira Henrique D.2,Simpson Eric L.3,Costanzo Antonio45,De Bruin-Weller Marjolein6,Barbarot Sebastien7,Prajapati Vimal H.89101112,Lio Peter1314,Hu Xiaofei2,Wu Tianshuang2,Liu John2,Ladizinski Barry2,Chu Alvina D.2,Eyerich Kilian1516

Affiliation:

1. Oregon Medical Research Center, Portland

2. AbbVie Inc, North Chicago, Illinois

3. Department of Dermatology, Oregon Health & Science University, Portland

4. Dermatology Unit, Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy

5. Humanitas Clinical and Research Center, Scientific Institute for Research, Hospitalization and Healthcare, Rozzano, Italy

6. Department of Dermatology and Allergology, University Medical Center Utrecht, Utrecht, the Netherlands

7. Department of Dermatology, Nantes Université, Centre Hospitalier Universitaire de Nantes, Nantes, France

8. Division of Dermatology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada

9. Division of Community Pediatrics, Department of Pediatrics, University of Calgary, Calgary, Alberta, Canada

10. Division of Pediatric Rheumatology, Department of Pediatrics, University of Calgary, Calgary, Alberta, Canada

11. Skin Health & Wellness Centre, Calgary, Alberta, Canada

12. Dermatology Research Institute, Calgary, Alberta, Canada

13. Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois

14. Medical Dermatology Associates of Chicago, Chicago, Illinois

15. Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden

16. Department of Dermatology and Allergy, Technical University of Munich, Munich, Germany

Publisher

American Medical Association (AMA)

Subject

Dermatology

Reference20 articles.

1. Atopic dermatitis.;Weidinger;Nat Rev Dis Primers,2018

2. Atopic dermatitis.;Langan;Lancet,2020

3. Targeting the Janus kinase family in autoimmune skin diseases.;Howell;Front Immunol,2019

4. JAK inhibitors for atopic dermatitis: an update.;He;Am J Clin Dermatol,2019

5. Two phase 3 trials of dupilumab versus placebo in atopic dermatitis.;Simpson;N Engl J Med,2016

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