Association Between Titin Loss-of-Function Variants and Early-Onset Atrial Fibrillation

Author:

Choi Seung Hoan1,Weng Lu-Chen12,Roselli Carolina1,Lin Honghuang34,Haggerty Christopher M.5,Shoemaker M. Benjamin6,Barnard John7,Arking Dan E.8,Chasman Daniel I.19,Albert Christine M.10,Chaffin Mark1,Tucker Nathan R.12,Smith Jonathan D.11,Gupta Namrata1,Gabriel Stacey1,Margolin Lauren1,Shea Marisa A.2,Shaffer Christian M.6,Yoneda Zachary T.6,Boerwinkle Eric12,Smith Nicholas L.13,Silverman Edwin K.14,Redline Susan15,Vasan Ramachandran S.3,Burchard Esteban G.16,Gogarten Stephanie M.17,Laurie Cecelia17,Blackwell Thomas W.18,Abecasis Gonçalo18,Carey David J.19,Fornwalt Brandon K.5,Smelser Diane T.19,Baras Aris20,Dewey Frederick E.20,Jaquish Cashell E.21,Papanicolaou George J.21,Sotoodehnia Nona22,Van Wagoner David R.23,Psaty Bruce M.13222425,Kathiresan Sekar1,Darbar Dawood26,Alonso Alvaro27,Heckbert Susan R.1324,Chung Mina K.28,Roden Dan M.6,Benjamin Emelia J.32930,Murray Michael F.31,Lunetta Kathryn L.332,Lubitz Steven A.1233,Ellinor Patrick T.1233,

Affiliation:

1. Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts

2. Cardiovascular Research Center, Massachusetts General Hospital, Boston

3. National Heart, Lung, and Blood Institute and Boston University’s Framingham Heart Study, Framingham, Massachusetts

4. Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts

5. Department of Imaging Science and Innovation, Geisinger, Danville, Pennsylvania

6. Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee

7. Departments of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio

8. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland

9. Divisions of Preventive Medicine and Genetics, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts

10. Divisions of Preventive and Cardiovascular Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts

11. Departments of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, Ohio

12. Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston

13. Department of Epidemiology and Cardiovascular Health Research Unit, University of Washington, Seattle

14. Channing Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts

15. Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women’s Hospital, Boston, Massachusetts

16. Department of Bioengineering, School of Pharmacy, University of California, San Francisco

17. Department of Biostatistics, University of Washington, Seattle

18. Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor

19. Department of Molecular and Functional Genomics, Geisinger, Danville, Pennsylvania

20. Regeneron Genetics Center, Tarrytown, New York

21. Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland

22. Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle

23. Departments of Molecular Cardiology, Cleveland Clinic, Cleveland, Ohio

24. Kaiser Permanente Washington Health Research Institute, Seattle, Washington

25. Department of Health Services, University of Washington, Seattle

26. Division of Cardiology, Department of Medicine, University of Illinois, Chicago

27. Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia

28. Departments of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio

29. Department of Medicine, Boston University School of Medicine, Boston, Massachusetts

30. Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts

31. Genomic Medicine Institute, Geisinger, Danville, Pennsylvania

32. Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts

33. Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston

Publisher

American Medical Association (AMA)

Subject

General Medicine

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