Effect of Stress Ulcer Prophylaxis With Proton Pump Inhibitors vs Histamine-2 Receptor Blockers on In-Hospital Mortality Among ICU Patients Receiving Invasive Mechanical Ventilation

Author:

,Young Paul J.12,Bagshaw Sean M.3,Forbes Andrew B.4,Nichol Alistair D.567,Wright Stephen E.8,Bailey Michael69,Bellomo Rinaldo6910,Beasley Richard1,Brickell Kathy7,Eastwood Glenn M.10,Gattas David J.1112,van Haren Frank13,Litton Edward14,Mackle Diane M.1,McArthur Colin J.115,McGuinness Shay P.116,Mouncey Paul R.17,Navarra Leanlove1,Opgenorth Dawn3,Pilcher David5618,Saxena Manoj K.1219,Webb Steve A.20,Wiley Daisy17,Rowan Kathryn M.17

Affiliation:

1. Medical Research Institute of New Zealand, Wellington

2. Intensive Care Unit, Wellington Hospital, Wellington, New Zealand

3. Department of Critical Care Medicine, University of Alberta Hospital, Edmonton, Canada

4. Biostatistics Unit, Monash University, Melbourne, Australia

5. Intensive Care Unit, Alfred Hospital, Melbourne, Australia

6. Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Australia

7. University College Dublin-Clinical Research Centre, St Vincent’s Hospital, Dublin, Ireland

8. Intensive Care Unit, Freeman Hospital, Newcastle upon Tyne, England

9. University of Melbourne, Melbourne, Australia

10. Intensive Care Unit, Austin Hospital, Heidelberg, Australia

11. Intensive Care Unit, Royal Prince Alfred Hospital, Camperdown, Australia

12. George Institute for Global Health, University of New South Wales, Sydney, Australia

13. Intensive Care Unit, Canberra Hospital, Canberra, Australia

14. Intensive Care Unit, Fiona Stanley Hospital, Murdoch, Australia

15. Department of Critical Care Medicine, Auckland City Hospital, Auckland, New Zealand

16. Cardiothoracic and Vascular Intensive Care Unit, Auckland City Hospital, Auckland, New Zealand

17. Intensive Care National Audit and Research Centre, London, England

18. Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation, Camberwell, Australia

19. Intensive Care Unit, Bankstown Hospital, Bankstown, Australia

20. Intensive Care Unit, Royal Perth Hospital, Perth, Australia

Publisher

American Medical Association (AMA)

Subject

General Medicine

Reference20 articles.

1. Prevalence and outcome of gastrointestinal bleeding and use of acid suppressants in acutely ill adult intensive care patients.;Krag;Intensive Care Med,2015

2. Pantoprazole in patients at risk for gastrointestinal bleeding in the ICU.;Krag;N Engl J Med,2018

3. Stress ulcer prophylaxis with proton pump inhibitors or histamin-2 receptor antagonists in adult intensive care patients: a systematic review with meta-analysis and trial sequential analysis.;Barbateskovic;Intensive Care Med,2019

4. A multicentre feasibility study evaluating stress ulcer prophylaxis using hospital-based registry data.;Litton;Crit Care Resusc,2014

5. Opinions and practice of stress ulcer prophylaxis in Australian and New Zealand intensive care units.;Eastwood;Crit Care Resusc,2014

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