Effect of Cell-Free DNA Screening vs Direct Invasive Diagnosis on Miscarriage Rates in Women With Pregnancies at High Risk of Trisomy 21

Author:

Malan Valérie123,Bussières Laurence45,Winer Norbert67,Jais Jean-Philippe38,Baptiste Amandine5,Le Lorc’h Marc1,Elie Caroline5,O’Gorman Neil34,Fries Nicolas910,Houfflin-Debarge Véronique711,Sentilhes Loic71213,Vekemans Michel13,Ville Yves34,Salomon Laurent J.34710,

Affiliation:

1. Department of Histology-Embryology and Cytogenetics, Hôpital Necker–Enfants Malades, AP-HP, Paris, France

2. INSERM U1163, Hôpital Necker–Enfants Malades, Paris, France

3. Paris Descartes University, Sorbonne Paris Cité, Institut Imagine, Paris, France

4. Department of Obstetrics and Gynecology, Hôpital Necker–Enfants Malades, AP-HP, Paris, France

5. Clinical Unit Research/Clinic Investigation Center, Paris Descartes, Hôpital Necker–Enfants Malades, AP-HP, Paris, France

6. Department of Obstetrics and Gynecology, CHU de Nantes, UMR 1280 PHAN (Physiologie des Adaptations Nutritionnelles), INRA University, Nantes, France

7. Groupe de Recherche en Obstétrique et Gynécologie (GROG), Paris, France

8. Department of Biostatistics and Medical Informatics, Hôpital Necker–Enfants Malades, AP-HP, Paris, France

9. Department of Obstetrics and Gynecology, CHU de Montpellier, Montpellier, France

10. Collège Français d’Echographie Fœtale (CFEF), Chateaubriand, France

11. Department of Obstetrics and Gynecology, CHU de Lille, Lille, France

12. Department of Obstetrics and Gynecology, CHU d’Angers, Angers, France

13. Department of Obstetrics and Gynecology, CHU de Bordeaux, Bordeaux, France

Publisher

American Medical Association (AMA)

Subject

General Medicine

Reference36 articles.

1. First trimester ultrasound tests alone or in combination with first trimester serum tests for Down’s syndrome screening.;Alldred;Cochrane Database Syst Rev,2017

2. Analysis of cell-free DNA in maternal blood in screening for aneuploidies: updated meta-analysis.;Gil;Ultrasound Obstet Gynecol,2017

3. Cell-free DNA analysis for noninvasive examination of trisomy.;Norton;N Engl J Med,2015

4. ISUOG updated consensus statement on the impact of cfDNA aneuploidy testing on screening policies and prenatal ultrasound practice.;Salomon;Ultrasound Obstet Gynecol,2017

5. Committee opinion summary No. 640: cell-free DNA screening for fetal aneuploidy.;Obstet Gynecol,2015

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