Association Between Low-Density Lipoprotein Cholesterol–Lowering Genetic Variants and Risk of Type 2 Diabetes

Author:

Lotta Luca A.1,Sharp Stephen J.1,Burgess Stephen2,Perry John R. B.1,Stewart Isobel D.1,Willems Sara M.1,Luan Jian’an1,Ardanaz Eva3,Arriola Larraitz4,Balkau Beverley5,Boeing Heiner6,Deloukas Panos7,Forouhi Nita G.1,Franks Paul W.8,Grioni Sara9,Kaaks Rudolf10,Key Timothy J.11,Navarro Carmen12,Nilsson Peter M.13,Overvad Kim14,Palli Domenico15,Panico Salvatore16,Quirós Jose-Ramón17,Riboli Elio18,Rolandsson Olov19,Sacerdote Carlotta20,Salamanca-Fernandez Elena21,Slimani Nadia22,Spijkerman Annemieke M. W.23,Tjonneland Anne24,Tumino Rosario25,van der A Daphne L.23,van der Schouw Yvonne T.26,McCarthy Mark I.27,Barroso Inês7,O’Rahilly Stephen28,Savage David B.28,Sattar Naveed29,Langenberg Claudia1,Scott Robert A.1,Wareham Nicholas J.1

Affiliation:

1. MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom

2. Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

3. Navarre Public Health Institute, Pamplona, Spain4Navarra Institute for Health Research, Pamplona, Spain5CIBER Epidemiología y Salud Pública, Madrid, Spain

4. CIBER Epidemiología y Salud Pública, Madrid, Spain6Public Health Division of Gipuzkoa, San Sebastian, Spain7Instituto BIO-Donostia, Basque Government, San Sebastian, Spain

5. Inserm, CESP, U1018, Villejuif, France9Université of Paris-Sud, UMRS 1018, Villejuif, France

6. German Institute of Human Nutrition, Potsdam-Rehbruecke, Germany

7. Wellcome Trust Sanger Institute, Cambridge, United Kingdom

8. Department of Clinical Sciences, Lund University, Skane University Hospital, Malmö, Sweden13Umeå University, Umeå, Sweden

9. Epidemiology and Prevention Unit, Milan, Italy

10. German Cancer Research Centre, Heidelberg, Germany

11. University of Oxford, Oxford, United Kingdom

12. CIBER Epidemiología y Salud Pública, Madrid, Spain17Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain18Unit of Preventive Medicine and Public Health, School of Medicine, University of Murcia, Murcia, Spain

13. Department of Clinical Sciences, Lund University, Skane University Hospital, Malmö, Sweden

14. Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark20Aalborg University Hospital, Aalborg, Denmark

15. Cancer Research and Prevention Institute, Florence, Italy

16. Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy

17. Public Health Directorate, Asturias, Spain

18. School of Public Health, Imperial College London, London, United Kingdom

19. Umeå University, Umeå, Sweden

20. Unit of Cancer Epidemiology, Citta' della Salute e della Scienza Hospital-University of Turin and Center for Cancer Prevention, Turin, Italy26Human Genetics Foundation, Turin, Italy

21. CIBER Epidemiología y Salud Pública, Madrid, Spain27Andalusian School of Public Health, Granada, Spain28Instituto de Investigación Biosanitaria de Granada, Granada, Spain

22. International Agency for Research on Cancer, Lyon, France

23. National Institute for Public Health and the Environment, Bilthoven, the Netherlands

24. Danish Cancer Society Research Center, Copenhagen, Denmark

25. Azienda Sanitaria Provinciale di Ragusa, Ragusa, Italy

26. University Medical Center Utrecht, Utrecht, the Netherlands

27. Oxford Centre for Diabetes, Endocrinology and Metabolism, and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

28. Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom

29. Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland

Publisher

American Medical Association (AMA)

Subject

General Medicine

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