Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease

Author:

Khera Amit V.1,Won Hong-Hee2,Peloso Gina M.3,O’Dushlaine Colm4,Liu Dajiang5,Stitziel Nathan O.6,Natarajan Pradeep1,Nomura Akihiro1,Emdin Connor A.1,Gupta Namrata7,Borecki Ingrid B.4,Asselta Rosanna8,Duga Stefano8,Merlini Piera Angelica9,Correa Adolfo10,Kessler Thorsten11,Wilson James G.12,Bown Matthew J.13,Hall Alistair S.14,Braund Peter S.13,Carey David J.15,Murray Michael F.15,Kirchner H. Lester15,Leader Joseph B.15,Lavage Daniel R.15,Manus J. Neil15,Hartzel Dustin N.15,Samani Nilesh J.13,Schunkert Heribert16,Marrugat Jaume17,Elosua Roberto17,McPherson Ruth18,Farrall Martin19,Watkins Hugh19,Lander Eric S.7,Rader Daniel J.20,Danesh John21,Ardissino Diego22,Gabriel Stacey7,Willer Cristen23,Abecasis Gonçalo R.24,Saleheen Danish25,Dewey Frederick E.4,Kathiresan Sekar1,

Affiliation:

1. Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts2Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston3Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston

2. Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Samsung Medical Center, Seoul, Republic of Korea

3. Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts5Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts

4. Regeneron Genetics Center, Tarrytown, New Jersey

5. Department of Public Health Sciences, Institute for Personalized Medicine, Penn State College of Medicine, Hershey, Pennsylvania

6. Department of Medicine, Washington University School of Medicine, St Louis, Missouri9Department of Genetics, Washington University School of Medicine, St Louis, Missouri10McDonnell Genome Institute, Washington University School of Medicine, St Louis, Missouri

7. Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts

8. Department of Biomedical Sciences, Humanitas University, Milan, Italy12Humanitas Clinical and Research Center, Milan, Italy

9. Ospedale Niguarda, Milano, Italy

10. Department of Medicine, University of Mississippi Medical Center, Jackson

11. Munich Heart Alliance, München, Germany16Deutsches Herzzentrum München, Technische Universität München, Deutsches Zentrum für Herz-Kreislauf-Forschung, München, Germany

12. Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson

13. NIHR Leicester Cardiovascular Biomedical Research Unit, Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom

14. Leeds Institute of Cardiovascular and Metabolic Medicine, Leeds University, Leeds, United Kingdom

15. Geisinger Health System, Danville, Pennsylvania

16. Deutsches Herzzentrum München, Technische Universität München, Deutsches Zentrum für Herz-Kreislauf-Forschung, München, Germany

17. Cardiovascular Epidemiology and Genetics, Hospital del Mar Research Institute, Barcelona, Spain

18. University of Ottawa Heart Institute, Ottawa, Ontario, Canada

19. Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom24Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

20. Department of Genetics, University of Pennsylvania, Philadelphia

21. Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom27Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom28NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom29Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia

22. Division of Cardiology, Azienda Ospedaliero–Universitaria di Parma, Parma, Italy31Associazione per lo Studio Della Trombosi in Cardiologia, Pavia, Italy

23. Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor33Department of Human Genetics, University of Michigan, Ann Arbor34Department of Internal Medicine, University of Michigan, Ann Arbor

24. Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor

25. Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia

Publisher

American Medical Association (AMA)

Subject

General Medicine

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