Association of Genetic Variants in NUDT15 With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel Disease-Reference-Cited by-同舟云学术

Association of Genetic Variants in NUDT15 With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel Disease

Published:2019-02-26 Issue:8 Volume:321 Page:773
ISSN:0098-7484
Container-title:JAMA
language:en
Short-container-title:JAMA

Author:

Walker Gareth J.¹²,Harrison James W.³,Heap Graham A.¹²,Voskuil Michiel D.⁴,Andersen Vibeke⁵,Anderson Carl A.⁶,Ananthakrishnan Ashwin N.⁷,Barrett Jeffrey C.⁶,Beaugerie Laurent⁸,Bewshea Claire M.²,Cole Andy T.⁹,Cummings Fraser R.¹⁰,Daly Mark J.¹¹,Ellul Pierre¹²,Fedorak Richard N.¹³,Festen Eleonora A. M.⁴,Florin Timothy H.¹⁴,Gaya Daniel R.¹⁵,Halfvarson Jonas¹⁶,Hart Ailsa L.¹⁷,Heerasing Neel M.¹²,Hendy Peter¹²,Irving Peter M.¹⁸,Jones Samuel E.³,Koskela Jukka¹¹,Lindsay James O.¹⁹,Mansfield John C.²⁰,McGovern Dermot²¹,Parkes Miles²²,Pollok Richard C. G.²³,Ramakrishnan Subramaniam²⁴,Rampton David S.²⁵,Rivas Manuel A.¹¹,Russell Richard K.²⁶,Schultz Michael²⁷,Sebastian Shaji²⁸,Seksik Philippe⁸,Singh Abhey¹,So Kenji¹,Sokol Harry⁸,Subramaniam Kavitha²⁹,Todd Anthony³⁰,Annese Vito³¹,Weersma Rinse K.⁴,Xavier Ramnik¹¹,Ward Rebecca³,Weedon Michael N.³,Goodhand James R.¹²,Kennedy Nicholas A.¹²,Ahmad Tariq¹²,

Affiliation:

1. Department of Gastroenterology, Royal Devon and Exeter Hospital NHS Foundation Trust, Exeter, England

2. IBD Pharmacogenetics Group, University of Exeter, Exeter, England

3. University of Exeter Medical School, Exeter, England

4. Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, the Netherlands

5. Medical Department, Regional Hospital Viborg, Viborg, Denmark

6. Wellcome Trust Sanger Institute, Hinxton, England

7. Department of Gastroenterology, Massachusetts General Hospital, Boston

8. Department of Gastroenterology, Saint-Antoine Hospital and Sorbonne Universite, Paris, France

9. Derby Digestive Diseases Centre, Royal Derby Hospital, Derby Teaching Hospitals NHS Foundation Trust, Derby, England

10. Department of Gastroenterology, Southampton General Hospital, University Hospital Southampton NHS Foundation Trust, Southampton, England

11. Broad Institute, Harvard University, Cambridge, Massachusetts

12. Department of Gastroenterology, Mater Dei Hospital, Msida, Malta

13. Division of Gastroenterology, University of Alberta, Edmonton, Canada

14. Mater Research Institute, University of Queensland, South Brisbane, Australia

15. Department of Gastroenterology, Glasgow Royal Infirmary, NHS Greater Glasgow and Clyde, Glasgow, Scotland

16. Division of Gastroenterology, Örebro University, Örebro, Sweden

17. Department of Gastroenterology, St Mark’s Hospital, London North West Healthcare NHS Trust, Harrow, England

18. Department of Gastroenterology, Guy’s and St Thomas’ NHS Foundation Trust, London, England

19. Centre for Immunobiology, Blizard Institute, Barts and the London School of Medicine, Queen Mary University of London, London, England

20. Department of Gastroenterology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, England

21. F. Widjaja Foundation Inflammatory Bowel Disease and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California

22. Department of Gastroenterology, Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, England

23. Department of Gastroenterology, St George’s Healthcare NHS Trust, Tooting, England

24. Gastrointestinal and Liver Services, Warrington and Halton Hospitals NHS Foundation Trust, Warrington, England

25. Department of Gastroenterology, Royal London Hospital, Barts Health NHS Trust, London, England

26. Department of Paediatric Gastroenterology, Royal Hospital for Children, NHS Greater Glasgow and Clyde, Glasgow, Scotland

27. Dunedin Hospital, Dunedin, New Zealand

28. Gastroenterology and Hepatology, Hull and East Yorkshire Hospitals NHS Trust, Hull, England

29. Canberra Hospital, Canberra, Australia

30. Department of Haematology, Royal Devon and Exeter Hospital NHS Foundation Trust, Exeter, England

31. Division of Gastroenterology, Azienda Ospedaliero Universitaria Careggi, Florence, Italy

Publisher

American Medical Association (AMA)

Subject

General Medicine

Link

http:///jama/article-pdf/321/8/773/17519045/jama_walker_2019_oi_190011.pdf

Reference37 articles.

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4. Thiopurine treatment in inflammatory bowel disease: clinical pharmacology and implication of pharmacogenetically guided dosing.;Teml;Clin Pharmacokinet,2007

5. Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn’s disease and severe myelosuppression during azathioprine therapy.;Colombel;Gastroenterology,2000

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