Association of Low-Density Lipoprotein Cholesterol–Related Genetic Variants With Aortic Valve Calcium and Incident Aortic Stenosis

Author:

Smith J. Gustav1,Luk Kevin2,Schulz Christina-Alexandra3,Engert James C.4,Do Ron5,Hindy George3,Rukh Gull3,Dufresne Line2,Almgren Peter3,Owens David S.6,Harris Tamara B.7,Peloso Gina M.8,Kerr Kathleen F.9,Wong Quenna9,Smith Albert V.10,Budoff Matthew J.11,Rotter Jerome I.11,Cupples L. Adrienne12,Rich Stephen13,Kathiresan Sekar14,Orho-Melander Marju3,Gudnason Vilmundur10,O’Donnell Christopher J.15,Post Wendy S.16,Thanassoulis George4

Affiliation:

1. Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden2Department of Heart Failure and Valvular Disease, Skåne University Hospital, Lund, Sweden3Department of Clinical Sciences, Lund University, Malmö, Sweden4Program in Medical and Pop

2. McGill University Health Center, Preventive and Genomic Cardiology, Montreal, Quebec, Canada

3. Department of Clinical Sciences, Lund University, Malmö, Sweden

4. McGill University Health Center, Preventive and Genomic Cardiology, Montreal, Quebec, Canada6McGill University Health Center and Research Institute, Department of Medicine, Montreal, Quebec, Canada

5. Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston

6. Department of Medicine, University of Washington, Seattle

7. National Institute on Aging, Bethesda, Maryland

8. Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts

9. Department of Biostatistics, University of Washington, Seattle

10. Icelandic Heart Association Research Institute, Kopavogur, Iceland12Faculty of Medicine, University of Iceland, Reykjavik, Iceland

11. Los Angeles Biomedical Research Institute at Harbor–UCLA, Los Angeles, California

12. Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts15Framingham Heart Study, Framingham, Massachusetts

13. University of Virginia, Charlottesville

14. Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts7Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston17Cardiology Division, Massachusetts General Hospi

15. Framingham Heart Study, Framingham, Massachusetts17Cardiology Division, Massachusetts General Hospital, Boston18NHLBI Cardiovascular Epidemiology and Human Genomics Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland

16. Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland

Publisher

American Medical Association (AMA)

Subject

General Medicine

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