Association of Type and Location ofBRCA1andBRCA2Mutations With Risk of Breast and Ovarian Cancer

Author:

Rebbeck Timothy R.1,Mitra Nandita2,Wan Fei2,Sinilnikova Olga M.3,Healey Sue4,McGuffog Lesley5,Mazoyer Sylvie3,Chenevix-Trench Georgia4,Easton Douglas F.5,Antoniou Antonis C.5,Nathanson Katherine L.6,Laitman Yael7,Kushnir Anya8,Paluch-Shimon Shani7,Berger Raanan9,Zidan Jamal10,Friedman Eitan7,Ehrencrona Hans11,Stenmark-Askmalm Marie12,Einbeigi Zakaria13,Loman Niklas14,Harbst Katja14,Rantala Johanna15,Melin Beatrice16,Huo Dezheng17,Olopade Olufunmilayo I.17,Seldon Joyce18,Ganz Patricia A.18,Nussbaum Robert L.19,Chan Salina B.20,Odunsi Kunle21,Gayther Simon A.22,Domchek Susan M.6,Arun Banu K.23,Lu Karen H.23,Mitchell Gillian24,Karlan Beth Y.25,Walsh Christine25,Lester Jenny25,Godwin Andrew K.26,Pathak Harsh26,Ross Eric27,Daly Mary B.28,Whittemore Alice S.20,John Esther M.29,Miron Alexander30,Terry Mary Beth31,Chung Wendy K.32,Goldgar David E.33,Buys Saundra S.34,Janavicius Ramunas35,Tihomirova Laima36,Tung Nadine37,Dorfling Cecilia M.38,van Rensburg Elizabeth J.38,Steele Linda39,Neuhausen Susan L.39,Ding Yuan Chun39,Ejlertsen Bent40,Gerdes Anne-Marie40,Hansen Thomas v. O.41,Ramón y Cajal Teresa42,Osorio Ana43,Benitez Javier44,Godino Javier45,Tejada Maria-Isabel46,Duran Mercedes47,Weitzel Jeffrey N.48,Bobolis Kristie A48,Sand Sharon R.48,Fontaine Annette48,Savarese Antonella49,Pasini Barbara50,Peissel Bernard51,Bonanni Bernardo52,Zaffaroni Daniela51,Vignolo-Lutati Francesca53,Scuvera Giulietta51,Giannini Giuseppe54,Bernard Loris55,Genuardi Maurizio56,Radice Paolo57,Dolcetti Riccardo58,Manoukian Siranoush51,Pensotti Valeria59,Gismondi Viviana60,Yannoukakos Drakoulis61,Fostira Florentia61,Garber Judy30,Torres Diana62,Rashid Muhammad Usman63,Hamann Ute64,Peock Susan5,Frost Debra5,Platte Radka5,Evans D. Gareth65,Eeles Rosalind66,Davidson Rosemarie67,Eccles Diana68,Cole Trevor69,Cook Jackie70,Brewer Carole71,Hodgson Shirley72,Morrison Patrick J.73,Walker Lisa74,Porteous Mary E.75,Kennedy M. John76,Izatt Louise77,Adlard Julian78,Donaldson Alan79,Ellis Steve5,Sharma Priyanka80,Schmutzler Rita Katharina81,Wappenschmidt Barbara81,Becker Alexandra81,Rhiem Kerstin81,Hahnen Eric81,Engel Christoph82,Meindl Alfons83,Engert Stefanie83,Ditsch Nina83,Arnold Norbert84,Plendl Hans Jörg85,Mundhenke Christoph84,Niederacher Dieter86,Fleisch Markus86,Sutter Christian87,Bartram C. R.87,Dikow Nicola87,Wang-Gohrke Shan88,Gadzicki Dorothea89,Steinemann Doris89,Kast Karin90,Beer Marit91,Varon-Mateeva Raymonda92,Gehrig Andrea93,Weber Bernhard H.94,Stoppa-Lyonnet Dominique95,Sinilnikova Olga M.96,Mazoyer Sylvie97,Houdayer Claude98,Belotti Muriel99,Gauthier-Villars Marion99,Damiola Francesca97,Boutry-Kryza Nadia100,Lasset Christine101,Sobol Hagay102,Peyrat Jean-Philippe103,Muller Danièle104,Fricker Jean-Pierre104,Collonge-Rame Marie-Agnès105,Mortemousque Isabelle106,Nogues Catherine107,Rouleau Etienne108,Isaacs Claudine109,De Paepe Anne110,Poppe Bruce110,Claes Kathleen110,De Leeneer Kim110,Piedmonte Marion111,Rodriguez Gustavo112,Wakely Katie113,Boggess John114,Blank Stephanie V.115,Basil Jack116,Azodi Masoud117,Phillips Kelly-Anne24,Caldes Trinidad118,de la Hoya Miguel118,Romero Atocha118,Nevanlinna Heli119,Aittomäki Kristiina120,van der Hout Annemarie H.121,Hogervorst Frans B. L.122,Verhoef Senno122,Collée J. Margriet123,Seynaeve Caroline124,Oosterwijk Jan C.121,Gille Johannes J. P.125,Wijnen Juul T.126,Garcia Encarna B. Gómez127,Kets Carolien M.128,Ausems Margreet G. E. M.129,Aalfs Cora M.130,Devilee Peter131,Mensenkamp Arjen R.128,Kwong Ava132,Olah Edith133,Papp Janos133,Diez Orland134,Lazaro Conxi135,Darder Esther136,Blanco Ignacio137,Salinas Mónica137,Jakubowska Anna138,Lubinski Jan138,Gronwald Jacek138,Jaworska-Bieniek Katarzyna139,Durda Katarzyna138,Sukiennicki Grzegorz138,Huzarski Tomasz138,Byrski Tomasz138,Cybulski Cezary138,Toloczko-Grabarek Aleksandra138,Zlowocka-Perlowska Elzbieta138,Menkiszak Janusz140,Arason Adalgeir141,Barkardottir Rosa B.141,Simard Jacques142,Laframboise Rachel143,Montagna Marco144,Agata Simona144,Alducci Elisa144,Peixoto Ana145,Teixeira Manuel R.146,Spurdle Amanda B.4,Lee Min Hyuk147,Park Sue K.148,Kim Sung-Won149,Friebel Tara M.2,Couch Fergus J.150,Lindor Noralane M.151,Pankratz Vernon S.151,Guidugli Lucia152,Wang Xianshu152,Tischkowitz Marc153,Foretova Lenka154,Vijai Joseph155,Offit Kenneth155,Robson Mark156,Rau-Murthy Rohini156,Kauff Noah156,Fink-Retter Anneliese157,Singer Christian F.157,Rappaport Christine157,Gschwantler-Kaulich Daphne157,Pfeiler Georg157,Tea Muy-Kheng157,Berger Andreas157,Greene Mark H.158,Mai Phuong L.158,Imyanitov Evgeny N.159,Toland Amanda Ewart160,Senter Leigha161,Bojesen Anders162,Pedersen Inge Sokilde163,Skytte Anne-Bine162,Sunde Lone164,Thomassen Mads165,Moeller Sanne Traasdahl165,Kruse Torben A.165,Jensen Uffe Birk164,Caligo Maria Adelaide166,Aretini Paolo166,Teo Soo-Hwang167,Selkirk Christina G.168,Hulick Peter J.168,Andrulis Irene169

Affiliation:

1. Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia2Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia

2. Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia

3. Centre de Recherche en Cancérologie de Lyon, UMR Inserm, Centre Léon Bérard, Lyon, France

4. Department of Genetics and Computational Biology, Queensland Institute of Medical Research, Brisbane, Australia

5. Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

6. Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia6Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia

7. Sheba Medical Center, Tel Aviv, Israel

8. Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel Hashomer, Israel

9. Oncology Institute, Sheba Medical Center, Tel Hashomer, Israel

10. Oncology Institute, Rivkah Ziv Medical Center Zefat, Israel

11. Department of Oncology, Lund University, Lund, Sweden12Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden

12. Division of Clinical Genetics, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden

13. Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden

14. Department of Oncology, Lund University, Lund, Sweden

15. Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden

16. Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden

17. Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, Illinois

18. UCLA Schools of Medicine and Public Health, Division of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Center, Los Angeles, California

19. Department of Medicine and Genetics, University of California, San Francisco

20. Cancer Risk Program, Helen Diller Family Cancer Center, University of California, San Francisco

21. Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York

22. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles

23. University of Texas MD Anderson Cancer Center, Houston

24. Division of Cancer Medicine, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia 25Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia

25. Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California

26. Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City

27. Fox Chase Cancer Center, Philadelphia, Pennsylvania

28. Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California

29. Department of Epidemiology, Cancer Prevention Institute of California, Fremont

30. Dana-Farber Cancer Institute, Boston, Massachusetts,

31. Department of Epidemiology, Columbia University, New York, New York

32. Departments of Pediatrics and Medicine, Columbia University, New York, New York

33. Department of Dermatology, University of Utah School of Medicine, Salt Lake City

34. Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City

35. Vilnius University Hospital Santariskiu Clinics, Hematology, Oncology, and Transfusion Medicine Center, Department of Molecular and Regenerative Medicine, State Research Institute Innovative Medicine Center, Vilnius, Lithuania

36. Latvian Biomedical Research and Study Centre, Riga, Latvia

37. Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts

38. Department of Genetics, University of Pretoria, Pretoria, South Africa

39. Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California

40. Departments of Oncology or Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

41. Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

42. Oncology Service, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain

43. Human Genetics Group, Spanish National Cancer Centre (CNIO), and Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain

44. Human Genetics Group and Genotyping Unit, Spanish National Cancer Centre (CNIO), and Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain

45. Hospital clinico Universitario “Lozano Blesa,” Instituto de investigación sanitaria de Aragón (IIS), Zaragoza, Spain

46. Molecular Genetics Laboratory (Department of Genetics), Cruces University Hospital Barakaldo, Bizkaia, Spain

47. Institute of Biology and Molecular Genetics. Universidad de Valladolid (IBGM-UVA), Valladolid, Spain

48. Clinical Cancer Genetics, City of Hope Clinical Cancer Genetics Community Research Network, Duarte, California

49. Unit of Genetic Counselling, Medical Oncology Department, Istituto Nazionale Tumori Regina Elena, Rome, Italy

50. Department of Medical Science, University of Turin, and AO Città della Salute e della Scienza, Turin, Italy

51. Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy

52. Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy

53. AO Città della Salute e della Scienza, Turin, Italy

54. Department of Molecular Medicine, University La Sapienza, Rome, Italy

55. Department of Experimental Oncology, Istituto Europeo di Oncologia, Milan, Italy57Cogentech Cancer Genetic Test Laboratory, Milan, Italy

56. Institute of Medical Genetics, Catholic University, “A. Gemelli” Hospital, Rome, Italy

57. Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy60IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy

58. Cancer Bioimmunotherapy Unit, Centro di Riferimento Oncologico, IRCCSCRO Aviano National Cancer Institute, Aviano (PN), Italy

59. Cogentech Cancer Genetic Test Laboratory, Milan, Italy60IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy

60. Unit of Hereditary Cancer, IRCCS AOU San Martino–IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy

61. Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research “Demokritos” Aghia Paraskevi Attikis, Athens, Greece

62. Instituto de Genética Humana, Pontificia Universidad Javeriana, Bogotá, Colombia65Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany

63. Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany 66Department of Basic Sciences, Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH & RC), Lahore, Pakistan

64. Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany

65. Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals, NHS Foundation Trust, Manchester, United Kingdom

66. Oncogenetics Team, Institute of Cancer Research and Royal Marsden, NHS Foundation Trust, London, United Kingdom

67. Ferguson-Smith Centre for Clinical Genetics, Yorkhill Hospitals, Glasgow, United Kingdom

68. Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, United Kingdom

69. West Midlands Regional Genetics Service, Birmingham Women’s Hospital Healthcare NHS Trust, Edgbaston, Birmingham, United Kingdom

70. Sheffield Clinical Genetics Service, Sheffield Children’s Hospital, Sheffield, United Kingdom

71. Department of Clinical Genetics, Royal Devon and Exeter Hospital, Exeter, United Kingdom

72. Clinical Genetics Department, St Georges Hospital, University of London, United Kingdom

73. Northern Ireland Regional Genetics Centre, Belfast City Hospital, Belfast, United Kingdom

74. Oxford Regional Genetics Service, Churchill Hospital, Oxford, United Kingdom

75. South East of Scotland Regional Genetics Service, Western General Hospital, Edinburgh, United Kingdom

76. Academic Unit of Clinical and Molecular Oncology, Trinity College Dublin and St James’s Hospital, Dublin, Eire

77. South East Thames Regional Genetics Service, Guy’s Hospital London, United Kingdom

78. Yorkshire Regional Genetics Service, Leeds, United Kingdom

79. South West Regional Genetics Service, Bristol, United Kingdom

80. Department of Hematology and Oncology, University of Kansas Medical Center, Kansas City

81. Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), and Center for Molecular Medicine Cologne (CMMC), Medical Faculty, University of Cologne and University Hospital Cologne, Cologne, Germany

82. Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany

83. Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Munich, Germany

84. Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, Campus Kiel, Germany

85. Institute of Human Genetics, University Medical Center Schleswig-Holstein, Campus Kiel, Germany

86. Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany

87. Institute of Human Genetics, Department of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany

88. Department of Gynaecology and Obstetrics, University Hospital Ulm, Ulm, Germany

89. Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany

90. Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany

91. Institute of Human Genetics, Technical University Dresden, Dresden, Germany

92. Institute of Human Genetics, Campus Virchov Klinikum, Charite Berlin, Berlin, Germany

93. Centre of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institute of Human Genetics, University of Würzburg, Würzburg, Germany

94. Institute of Human Genetics, University of Regensburg, Regensburg, Germany

95. Institut Curie, Department of Tumour Biology, Paris, France98Institut Curie, INSERM U830, Paris, France99Université Paris Descartes, Sorbonne Paris Cité, France

96. Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon–Centre Léon Bérard, Lyon, France101INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France

97. INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France

98. Institut Curie, Department of Tumour Biology, Paris, France99Université Paris Descartes, Sorbonne Paris Cité, France

99. Institut Curie, Department of Tumour Biology, Paris, France

100. Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon–Centre Léon Bérard, Lyon, France

101. Université Lyon 1, CNRS UMR5558, Lyon, France103Unité de Prévention et d’Epidémiologie Génétique, Centre Léon Bérard, Lyon, France

102. Département Oncologie Génétique, Prévention et Dépistage, INSERM CIC-P9502, Institut Paoli-Calmettes/Université d’Aix-Marseille II, Marseille, France

103. Laboratoire d’Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France

104. Unité d’Oncogénétique, CLCC Paul Strauss, Strasbourg, France

105. Service de Génétique Biologique-Histologie-Biologie du Développement et de la Reproduction, Centre Hospitalier Universitaire de Besançon, Besançon, France

106. Service de Génétique, Centre Hospitalier Universitaire Bretonneau, Tours, France

107. Oncogénétique Clinique, Hôpital René Huguenin/Institut Curie, Saint-Cloud, France

108. Laboratoire d’Oncogénétique, Hôpital René Huguenin/Institut Curie, Saint-Cloud, France

109. Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC

110. Center for Medical Genetics, Ghent University, Ghent, Belgium

111. GOG Statistical and Data Center, Buffalo, New York

112. Evanston Hospital, Evanston, Illinois

113. Tufts University, Medford, Massachusetts

114. University of North Carolina, Chapel Hill

115. New York University, New York, New York

116. Ohio State, Good Samaritan Hospital, Cincinnati

117. Yale University School of Medicine, New Haven, Connecticut

118. Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC, Madrid, Spain

119. Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland

120. Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland

121. Department of Genetics, University Medical Center, Groningen University, Groningen, The Netherlands

122. Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, The Netherlands

123. Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands

124. Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands

125. Department of Clinical Genetics, VU University Medical Centre, Amsterdam, The Netherlands

126. Department of Human Genetics and Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands

127. Department of Clinical Genetics and GROW, School for Oncology and Developmental Biology, MUMC, Maastricht, The Netherlands

128. Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

129. Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands

130. Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands

131. Department of Human Genetics and Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands

132. Hong Kong Hereditary Breast Cancer Family Registry, Hong Kong135Cancer Genetics Center, Hong Kong Sanatorium and Hospital, Hong Kong136Department of Surgery, University of Hong Kong, Hong Kong

133. Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary

134. Oncogenetics Laboratory, Vall d’Hebron Institute of Oncology (VHIO), Universitat Autonoma de Barcelona, Barcelona, Spain139University Hospital of Vall d’Hebron, Barcelona, Spain

135. Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain

136. Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI-Catalan Institute of Oncology, Girona, Spain

137. Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain

138. Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland

139. Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland144Postgraduate School of Molecular Medicine, Warsaw Medical University, Warsaw, Poland

140. Department of Surgical Gynecology and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University, Szczecin, Poland

141. Department of Pathology, Landspitali University Hospital, Reykjavík, Iceland147BMC, Faculty of Medicine, University of Iceland, Reykjavik, Iceland

142. Canada Research Chair in Oncogenetics, Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec Research Center, Quebec City, Quebec, Canada149Laval University, Quebec City, Quebec, Canada

143. Medical Genetics Division, Centre Hospitalier Universitaire de Québec, Quebec City, Quebec, Canada151Immunology and Molecular Oncology Unit, Veneto Institute of Oncology, IOV-IRCCS, Padua, Italy

144. Immunology and Molecular Oncology Unit, Veneto Institute of Oncology, IOV-IRCCS, Padua, Italy

145. Department of Genetics, Portuguese Oncology Institute, Porto, Portugal

146. Department of Genetics, Portuguese Oncology Institute, Porto, Portugal153Biomedical Sciences Institute (ICBAS), University of Porto, Portugal

147. Department of Surgery, Soonchunhyang University and Hospital, Seoul, Korea

148. Department of Preventive Medicine, Seoul National University College of Medicine and Cancer Research Institute, Seoul National University, Seoul, Korea

149. Department of Surgery, Daerim St Mary’s Hospital, Seoul, Korea

150. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota159Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota

151. Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota

152. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota

153. Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal, Quebec, Canada161Department of Medical Genetics, University of Cambridge, Cambridge, United Kingdom

154. Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute and MF MU, Brno, Czech Republic

155. Clinical Genetics Service, Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York

156. Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, New York

157. Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria

158. Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland

159. N. N. Petrov Institute of Oncology, St Petersburg, Russia

160. Divison of Human Cancer Genetics, Departments of Internal Medicine and Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus

161. Divison of Human Genetics, Department of Internal Medicine, Comprehensive Cancer Center, Ohio State University, Columbus

162. Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark

163. Section of Molecular Diagnostics, Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark

164. Department of Clinical Genetics, Aarhus University Hospital, Aarhus N, Denmark

165. Department of Clinical Genetics, Odense University Hospital, Odense C, Denmark

166. Section of Genetic Oncology, Department of Oncology, University of Pisa and University Hospital of Pisa, Pisa, Italy

167. Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia176Department of Surgery, Faculty of Medicine, University Malaya Cancer Research Institute, University Malaya, Kuala Lumpur, Malaysia

168. NorthShore University HealthSystem, Department of Medicine, Evanston, Illinois

169. Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada

Publisher

American Medical Association (AMA)

Subject

General Medicine

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