Molecular Diagnostic Yield of Chromosomal Microarray Analysis and Whole-Exome Sequencing in Children With Autism Spectrum Disorder

Author:

Tammimies Kristiina1,Marshall Christian R.2,Walker Susan3,Kaur Gaganjot3,Thiruvahindrapuram Bhooma3,Lionel Anath C.3,Yuen Ryan K. C.3,Uddin Mohammed3,Roberts Wendy4,Weksberg Rosanna5,Woodbury-Smith Marc6,Zwaigenbaum Lonnie7,Anagnostou Evdokia8,Wang Zhuozhi3,Wei John3,Howe Jennifer L.3,Gazzellone Matthew J.3,Lau Lynette2,Sung Wilson W. L.3,Whitten Kathy9,Vardy Cathy10,Crosbie Victoria10,Tsang Brian3,D’Abate Lia3,Tong Winnie W. L.3,Luscombe Sandra11,Doyle Tyna10,Carter Melissa T.12,Szatmari Peter13,Stuckless Susan14,Merico Daniele3,Stavropoulos Dimitri J.15,Scherer Stephen W.16,Fernandez Bridget A.17

Affiliation:

1. The Centre for Applied Genomics, Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada2Center of Neurodevelopmental Disorders (KIND), Pediatric Neuropsychiatry Unit, Department of Women’s and Children’s Health, K

2. The Centre for Applied Genomics, Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada3Genome Diagnostics, Department of Pediatrics Laboratory Medicine, The Hospital for Sick Children, Toronto, Canada

3. The Centre for Applied Genomics, Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada

4. Autism Research Unit, The Hospital for Sick Children, Toronto, Ontario, Canada

5. Department of Pediatrics and Genome Biology Program, The Hospital for Sick Children and Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada

6. Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada

7. Department of Pediatrics, University of Alberta, Edmonton, Canada

8. Bloorview Research Institute, Toronto, Ontario, Canada

9. Provincial Medical Genetics Program, Eastern Health, St John’s, Newfoundland and Labrador, Canada

10. Child Health Program, Eastern Health, St John’s, Newfoundland and Labrador, Canada13Discipline of Pediatrics, Memorial University of Newfoundland, St John’s, Newfoundland and Labrador, Canada

11. Child Health Program, Eastern Health, St John’s, Newfoundland and Labrador, Canada

12. Department of Pediatrics, Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, Toronto, Ontario, Canada

13. Centre for Addiction and Mental Health, The Hospital for Sick Children, University of Toronto, Toronto, Canada

14. Disciplines of Genetics and Medicine, Memorial University of Newfoundland, St John’s, Newfoundland and Labrador, Canada

15. Genome Diagnostics, Department of Pediatrics Laboratory Medicine, The Hospital for Sick Children, Toronto, Canada15Cytogenetics Laboratory, Department of Pediatrics Laboratory Medicine, The Hospital for Sick Children, Toronto, Canada

16. The Centre for Applied Genomics, Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada16Department of Molecular Genetics and the McLaughlin Centre, University of Toronto, Toronto, Canada

17. Provincial Medical Genetics Program, Eastern Health, St John’s, Newfoundland and Labrador, Canada14Disciplines of Genetics and Medicine, Memorial University of Newfoundland, St John’s, Newfoundland and Labrador, Canada

Publisher

American Medical Association (AMA)

Subject

General Medicine

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