Interpreting the Results of Intention-to-Treat, Per-Protocol, and As-Treated Analyses of Clinical Trials-Reference-Cited by-同舟云学术

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Interpreting the Results of Intention-to-Treat, Per-Protocol, and As-Treated Analyses of Clinical Trials

Published:2021-08-03 Issue:5 Volume:326 Page:433
ISSN:0098-7484
Container-title:JAMA
language:en
Short-container-title:JAMA

Author:

Smith Valerie A.¹²,Coffman Cynthia J.²³,Hudgens Michael G.⁴

Affiliation:

1. Department of Population Health Sciences, Duke University, Durham, North Carolina

2. Center of Innovation to Accelerate Discovery and Practice Transformation (ADAPT), Durham VA Medical Center, Durham, North Carolina

3. Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina

4. Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill

Publisher

American Medical Association (AMA)

Subject

General Medicine

Link

https://jamanetwork.com/journals/jama/articlepdf/2782658/jama_smith_2021_gm_210002_1627852659.59255.pdf

Reference4 articles.

1. Effect of catheter ablation vs antiarrhythmic drug therapy on mortality, stroke, bleeding, and cardiac arrest among patients with atrial fibrillation: the CABANA randomized clinical trial.;Packer;JAMA,2019

2. The intention-to-treat principle: how to assess the true effect of choosing a medical treatment.;Detry;JAMA,2014

3. Beyond the intention-to-treat in comparative effectiveness research.;Hernán;Clin Trials,2012

4. Per-protocol analyses of pragmatic trials.;Hernán;N Engl J Med,2017

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