Detection of Pathogenic Variants With Germline Genetic Testing Using Deep Learning vs Standard Methods in Patients With Prostate Cancer and Melanoma-Reference-Cited by-同舟云学术

Detection of Pathogenic Variants With Germline Genetic Testing Using Deep Learning vs Standard Methods in Patients With Prostate Cancer and Melanoma

Published:2020-11-17 Issue:19 Volume:324 Page:1957
ISSN:0098-7484
Container-title:JAMA
language:en
Short-container-title:JAMA

Author:

AlDubayan Saud H.¹²³⁴,Conway Jake R.¹²⁵,Camp Sabrina Y.¹²,Witkowski Leora⁶,Kofman Eric¹²,Reardon Brendan¹²,Han Seunghun¹²⁷,Moore Nicholas¹²,Elmarakeby Haitham¹²⁸,Salari Keyan⁹,Choudhry Hani¹⁰,Al-Rubaish Abdullah M.¹¹,Al-Sulaiman Abdulsalam A.¹¹,Al-Ali Amein K.¹¹,Taylor-Weiner Amaro²⁵,Van Allen Eliezer M.¹²

Affiliation:

1. Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Harvard University, Boston, Massachusetts

2. Cancer Program, Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge

3. Division of Genetics, Brigham and Women’s Hospital, Boston, Massachusetts

4. College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia

5. Division of Medical Sciences, Department of Biomedical Informatics, Harvard University, Boston, Massachusetts

6. Genetics Training Program, Harvard Medical School, Harvard University, Boston, Massachusetts

7. Program in Biological and Biomedical Sciences, Division of Medical Sciences, Harvard University, Boston, Massachusetts

8. Department of System and Computer Engineering, Al-Azhar University, Cairo, Egypt

9. Department of Urology, Massachusetts General Hospital, Boston

10. Department of Biochemistry, Cancer Metabolism and Epigenetic Unit, Faculty of Science, Cancer and Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia

11. College of Medicine, Imam Abdulrahman bin Faisal University, Dammam, Saudi Arabia

Publisher

American Medical Association (AMA)

Subject

General Medicine

Link

https://jamanetwork.com/journals/jama/articlepdf/2772962/jama_aldubayan_2020_oi_200115_1605024515.70993.pdf

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5. Association of inherited pathogenic variants in checkpoint kinase 2 (CHEK2) with susceptibility to testicular germ cell tumors.;AlDubayan;JAMA Oncol,2019

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