RNA Interference With Zilebesiran for Mild to Moderate Hypertension
Author:
Bakris George L.1, Saxena Manish23, Gupta Anil4, Chalhoub Fadi5, Lee Jongtae6, Stiglitz Daniel6, Makarova Nune6, Goyal Nitender6, Guo Weinong6, Zappe Dion6, Desai Akshay S.7, , Carr George8, Case Christopher8, Jaeger Lauren8, Bruns Lisa8, Stratman Ginger8, Kidwell Christy8, Cunningham Suzin8, Piccone Nicholas8, Klein Mordecai8, Acuna Maria8, Arora Srishti8, Clark Amanda8, Fink Ezekiel8, Garcia Cesia8, George Astrid8, Gray Elizabeth8, Mahaffey Caroline8, McElheney Maria8, Ortiz Elizabeth8, Saumya Sunny8, Wallace Adele8, Watts Jenelle8, Zambrana Daisy8, Denham Douglas8, Rivera Erica8, Avworo Ayoade8, Hedges Parke8, Fancher Corri8, Abadier Rafik8, Braud Lisa8, Cenatiempo Laura8, Elwood Amanda8, Gray Linda8, Gray Peter8, Griffin Kimberly8, Khan Hasibul8, Kongquee Nadeen8, LaTorraca Susan8, Liles Tiffany8, Livingston Jill8, Lozano Marc8, Lupton Amy8, Lyles Tiffany8, Mardini Deana8, Moss Susan8, Packer Karen8, Patel Aakash8, Russ Tina8, Scinicariello Brianna8, Trull Shannon8, Warren Blair8, Chalhoub Fadi8, Angel Susan8, Dhakhwa Sujeeta8, Gabon Ivy8, Goodwin Leticia8, Joshi Jones Nandita8, Joyce Mark8, Kamble Niketa8, McFall Brooke8, Githiiyu Rose8, Robinson Leticia8, Tomlinson Lauren8, Hadziavdic Emir8, Vega Stephany8, Greenwald James8, Achan Jessica8, Ruiz Lucille8, Buksh Mehwish8, Chauhan Omkar8, Derisseau Elisee8, Ferguson Faith8, Grabowski Monika8, Gumerova Larisa8, Hernandez Miriam8, Martin Kenna8, Patel Krina8, Nanda Dibnain8, Perez Jose8, Ribeca Corey8, Rueda Elijah8, Sordi Guth Ana8, Zaki Nader8, Green Ebony8, Mondoc Nina8, Buynak Robert8, Andree Stephanie8, Brazinsky Martha8, Fuller Lisa8, Green Nikki8, Ibrahim Hannade8, Idowu Marilyn8, Lee Miranda8, Lewis Erica8, Luna Goldie8, McNeal Rachel8, Owens Alicia8, Perez Consuelita8, Petty Taryn8, Smith Megan8, Volom Patricia8, Webb Angela8, Williams Destiny8, Yarosz Mark8, Gabra Nashwa8, Andrawis Nabil8, Aziz Amy8, Hanna Magda8, Manalo Josefina8, Helow Victoria8, Davila William8, Crisp Sydney8, Douglas Yvonne8, Everett Jenna8, Graham Sarah8, Heard Ellen8, Mackie Michelle8, Mayer Suman8, Moore Lisa8, Resurreccion Stephanie8, Sidey Jennifer8, Stephens Michael8, Strickland Mary8, Van Camp Dawn8, Wilder Stephanie8, Witt Anne8, Wolfer Jolenne8, Groben Lucas8, Aeschliman Lindsey8, Audlehelm Emily8, Fitz Casey8, Greene Judi8, Hippen Emily8, Johnson Michelle8, Latcham Allan8, Leggett Shekela8, Link Keeta8, Lovell James8, Marlow Kourtney8, Marske Cynthia8, Maxwell Kelsey8, Newsom-Henderson Charlotte8, Oelberg Darcie8, Ollinger Kathleen8, Risius Rebecca8, Ryther Kylea8, Waddell Alyssa8, Zellerman Tyler8, Albornoz Santofimio Martin8, Plantholt Stephen8, Beatty Morgan8, Blubaugh Heather8, Bootz Tina8, Cole Jeffrey8, Conners Jasmine8, Coombs Vicki8, Goddard Chloe8, Ince Carlos8, Kiddy Gail8, Klimuszka Barbara8, Kuhn Frederick8, Lowry David8, Previll Patricia8, Rioux Stephanie8, Scott Jasmine8, Shepherd Britney8, Urffer Amy8, Smiley Sarah8, Lucksinger Gregg8, Alvord Allison8, Anderson Jordan8, Block Courtney8, Chan Ashley8, Delgado John8, Frost Kambrea8, Gadbois Levi8, Hamlin Danuel8, Johnson Sarah8, Juncal Vivianna8, Kelly Kary8, Kelly Emily8, Kelly Lilly8, Kerwin Avery8, Kuehl Audrey8, Ostovar Jaleh8, Rackley Ryan8, Rocha George8, Sandberg Lacee8, Sheghewi Sarah8, Smith Tiffany8, Taucher Ben8, Vasquez Cecilia8, Villa Rodriguez Francisca8, Weisbart Jay8, Wescom Veronica8, Williams Keenan8, Overcash Jeffrey Scott8, Anorve Angela8, Asmann Hunter8, Bovee Gordon8, Castillo Laura8, Chu Hanh8, Coslet Jordan8, Davis Allison8, Dinan Mary8, Dubbula Amanda8, Esparza Jacob8, Foster Ann8, Garcia Andrea8, Gonzales Jessica8, Gonzalez Lizette8, Kappen Pat8, Kornblatt Allison8, Lauderdale Brandon8, Lee Kia8, Lindholm Sylvia8, Lindsay Ashliegh8, Llanos Gomez Luis8, Marquez Adrienna8, Meza Catherine8, Odom Shandel8, Orel Makenna8, Paselio Shanna8, Penziner Samuel8, Pu Helen8, Quillin Kimberly8, Ramirez Cesar8, Ramirez Roxanna8, Salgado Monica8, Shores Marcy8, Taitingfong Raquel8, Tande Jennifer8, Tuiletufuga Van8, Tyler Katrina8, Vega Linda8, Zepeda Karla8, Anderson Corey8, Carhill Nikki8, Clark Benjamin8, Dean Lisa8, Devine Naomi8, DiPeri Sophia8, Espinal Gladys8, Hawkins Ronald8, Irra Gabriela8, Ledezma Angela8, Lopez-Wood Georgina8, Luna Micaela8, Mansour Wael8, Marriott Tasha8, Perez Ashley8, Ramsey James8, Reedy William8, Spinks Hannah8, Tanori Cecilia8, Tatelbaum David8, Vasquez Rudy8, Vasquez Kim8, Vigil Jori8, Worthen Isabel8, Yu Devin8, Zuniga Jessica8, Dennis Patrick8, Alvarado Lauren8, Cox Armand8, Cullaro Victoria8, Dunbar John8, Giorlando Katherine8, Hannan London8, Hastings Tyler8, Hoskins Geoff8, Krambeck Emily8, Laurent Juliana8, Martinez Olga Michelle8, Mister Reggie8, Moss Autumn8, Muli Margaret8, Quinn Nicolette8, Reed Brittany8, Robinson Adam8, Saavedra Casey8, Simon Caitlin8, Smith Derek8, Touchet Dylan8, Wright Annie8, Trevino Miguel8, DeVries Benjamin8, Allison-Hicks Sara8, Light Timothy8, Rubach Wendy8, Mai Kimberly8, Osborn Tracey8, Sheets Lori8, Carver Dusty8, Reichman Alan8, Lotfi Djamchid8, Berrios Nelson8, Vulichi Sangeetha8, Naguleswaran Tulashi8, Subhan Yvonne8, Rios Monica8, Baron Diana8, Khowaja Abdul8, Nair Siddharth8, Vicente Michael8, Gonzalez Gomez Luvia Lizette8, Acevedo Gomez Uriel Salvador8, Lamichhane Janak8, Ekomoda Efe8, Nair Akhila8, Maldonado Shana8, Naqvi Mobina8, Dayani Fahim8, Patro Sontoshi8, Golandaz LubnaGazal8, Jaka Amin8, Rios Santiago8, Gurung Maushami8, Gongloor Pratik8, Coreas David8, Demir Tarik8, Celik Zehra8, McGill Lora8, Usdan Lisa8, Arnold Valerie8, Heckle Keerthi8, Scatamacchia Carolyn8, Anthony Codi8, Marsh Carol8, Fair Jernell8, Stewart Anekeya8, Hamlet Rebecca8, Presley Robyn8, Granberry Charles8, Flowers Melissa8, Houpt Cathy8, O'Brien Debra8, Evans Kelsey8, Williams Mary8, Sinatra Julia8, Powell Irene8, Flagg Tavia8, Pipkin LaKeshia8, Wheeler Vanessa8, Wells Erin8, Gruber Brandi8, Jones Amber8, Toor Monica8, Iskiwitz Kelly8, Boyd Mia8, Epps Sharneiseca8, Cole Frank8, Grayson-Mathis Charlotte8, Web Maci8, Turner Catrina8, Reese Krystal8, Robinson Dana8, Goodwin Atira8, Parker Kyle8, Ward Chantelle8, Solomon Amber8, Lawson Taylor8, Pledger Marquita8, Lane Peterson Amanda8, Carignan Monique8, Oguoma-Richards David8, Jones Stacy8, McFarland-Head Kiara8, Bundeff Brittany8, Wojtowicz Stephanie8, Holland Cynthia8, Sanders Taylor8, Simon Lee8, Lawrence Caitlin8, Bolton Brittany8, Lemoine Kandice8, Harris Kasey8, Kingsley Hilary8, Bryant Danielle8, Clawson Korie8, Murphy Colleen8, Crawford Allison Dale8, Newman Gregory8, Preece Dedra8, Zook Pamela8, Roznos Taylor8, Russell Sharla8, Rodriguez Richard8, Roy Angela8, Layle Stacey8, Mehra Purvi8, Bowen Samantha8, Johnson Daniel8, Guillen Natalie8, Leone Sofia8, McCormick Guinevere8, Hermann Laurel8, Sarno Lerner8, Abellatif Taher8, Cleghorn Monica8, Elansary Aya8, Israel Athalyah8, Leeward Michelle8, Parra Claudia8, Harris Sydney8, Patel Prianka8, Cawley Megan8, Castro Myrna8, Miroshnikova Tatyana8, Dever Michael8, Venereo Jorge8, Paez Henry8, Isla Andres8, Martin Yailin8, Fernandez Ana8, Hernandez Isabel8, Isla Lavoy Andrew8, Rios Nancy8, Hernandez Armando8, Denenberg Michael8, McTier Treacy8, Reynolds Caroline8, Thomas Lacie8, Eubanks Connie8, Oliver Tori8, Jacobs Michael8, Mirkil Vincent8, Menasche Kathleen8, Yee Michael8, Alvarado Vasquez Bonny8, Garcia Candice8, Elio Laura8, Arenas Allan8, Buena Clarissa8, Garcia Cristina8, Cannon Michael8, Novotny Erin8, Oliver Michelle8, Cannon Amanda8, Gatdula Mark8, Gillenwater Cyn8, Rafi Adam8, Derian Wissam8, Ramsey Miranda8, Culbreth Evan8, Fessler Catherine8, Sorrill Kelly8, Mauri Monica8, Rosen Jeffrey8, Acosta Olga8, Brauchle Walter8, Castaneda Dadllany8, Castells Mailyn8, Castro Daniela8, Cespedes Laplace Maria Bibiana8, Flerisme Magdala8, Garcia Rocio8, Gomez Julio8, Hidalgo Michael8, Jimenez Gabriela8, Legon Miguel8, Lella Victoria8, Lemus Kimanys8, Rico-Aramillo Sheilla8, Rodriguez Maria8, Rodriguez Yelida8, Salazar Latisha8, Santana Carlos8, Tercero Nelly8, Martin Earl E.8, Acevedo Maria8, Anderson Amy8, Baig Talha8, Baker Rana8, Basrai Reemsha8, Cabrera Nora8, Caroll Cassidy8, Chatmon Shanika8, Cheema Sukhvinder8, Chowdhry Anum8, Cordero Nicole8, Deandres Carolina8, Deshpande Mounika8, Dileep Ambily8, Dolfi Kimberly8, Eng Lara8, Fountain Niccirria8, Gali Ramani8, Hernandez Adrienne8, Iskandar Arsani8, Khan Riaz8, Knight Adrianna8, Kundapati Soni8, Lobo Irma8, Lokhandwala Zahra8, Lokhandwala Zara8, Mahmood Faryal8, Marediya Rifa8, Martin Earl F8, Melendez Mirella8, Moosa Asfand8, Motiwala Alefiyah8, Muhebb Shamnun8, Murray Monica8, Rehman Muneeb8, Rivera Ariel8, Shah Ashay8, Solorzano Sara8, Somani Laila8, Soneira Loreta8, Starr Amy8, Thompson Danielle8, Torres Andrea8, Tran Elizabeth8, Ullah Mohammad Ali8, Valentine Allie8, Vaquerano Laura8, Yake Amanda8, Yousif Yousra8, Zaldivar Ashley8, Byars William8, Brown Hillary8, Claire Gaskin Anne8, Clayton Caitlynn8, Davis Christopher8, Dillon Sydney8, Driggers Belinda8, Ferrell Anfernee8, Green Danielle Elizabeth8, Hunt Lisa8, Jeffers Cathleen8, Kirkland Cindy8, Lopez Lina8, Mayfield Ronald8, Mercer Carole8, Parsons Kathy8, Patton Sharon8, Puck Kayla8, Restrepo Lina8, Sheppard Tanya8, Teachman Gina8, Velez Jessica8, Whitehead Amanda8, Jain Mahendra8, Asanji Gloria8, Garrett Jennifer8, Gill Katie8, Hester DeAndrea8, Jain Bela8, Mitchell Yvette8, Becker Teresa8, McKeown-Biagas Cecilia8, Fragoso Veronica8, Holloway Lisa8, Kowalski Tracy8, Barr Shakira8, Colville Bonnie8, Yang Chen-Ho8, Glasper Danitra8, Phuah Allan8, Miller Vicki8, Schmidt Sheila8, Jafri Ashraf8, Sureshbabu Waheeda8, Mir Leena8, Sharma Stuti8, Asaad Saja8, Hasnain Muhammad8, Ngo Tru8, Hari Devi8, Oheri Ikenna8, Patwary Asma8, Mohamed Mahmoud8, Hernandez Priscilla8, Gioia Jonatan8, Dalal Abdeali8, Ngban Pauline8, Smith Sandra8, Martinez Leal Bernardo8, Assaf Akram8, Martinez Alondra8, Khan Khola8, Castello Jacqueline8, Potapenko Mariya8, Wahaj Zurzar8, Elmachtoub Faris8, Akhtar Amna8, Areeb Siddiqui Muhammad8, Jamal Maira8, Rizvi Mohammad8, Sainz Karina8, Lucky-Dania Sarah8, Villarreal Stacy8, Fernandez William8, Hampton Shamarrian8, Bellamy Jerry8, Brown Lonisha8, Doran Evan8, Manzanares Eduardo8, Palmer James8, Sanders Aaron8, Bokhari Faraya8, Fenuyi Omowunmi8, Greer Clarissia8, Jang Hansol8, Juanillo Andrea8, Reese Crystal8, Narla Dheeraj8, Okoko Ijeoma8, Woodham Cara8, Eaton Rose8, Khawaja Shariqa8, Mushtag Tehreem8, Nisar Bhutto Asifa8, Solorsano Sara8, Ahmed Sajeel8, Shamim Rabia8, Gonzalez Norma8, Ardoin Felicia8, Moore Joshua8, Nuncio Nina8, Ray Eric8, Sikes Kara8, Troutman Imani8, West Natasha8, Wilson Quiana8, Young Nikisha8, Baloch Misbah8, Karimjee Najmuddin8, Carroll Kristy8, Broachwala Sakina8, Calais Natalee8, Laabs Jessica8, Marler Karen8, Rizvi Samana8, Syed Amar8, Syed Narjis8, Rizvi Zamir8, Hariwala Zohair8, Gloyd Patty8, Rizvi Abid8, Marcum Benjamin8, Carswell Joshua8, Fanning Cortney8, Bull Lesslie8, Corta Peter8, James Holly8, Martinez David8, Scurlark Robin8, Elliott Stephanie8, Beck Sydney8, Beck Cayla8, Glover Sarah8, Bonson Jasmine8, Patel Tanisha8, Matthew Garrett8, Davidoff Kyla8, Vesely Jim8, Horton Cyrus8, Barbour Rebecca8, Pereira Isabel8, Rivero Gina8, Alston Denise8, Miller Paulina8, Downing Frances8, Sanchez Crespo Nelia8, Schwartz Howard8, Mederos Surisaday8, Tamayo Janet Sentil8, Shapiro Craig8, Mallet Orbein8, Plotka Karenda8, Valladares Carlos8, Palmer Karenda8, Deltejo Dayana8, Garcia Katherine8, Camacho Marilein8, Chanza Yarixa8, Morera Jocelyn8, Davis Claudette8, Dawson Karlene8, Rosales Vivian8, Torres Dunia8, Pinero Maria8, Cruz Catherine8, Rivera Beatriz8, Balebona Patricia8, Basurco Andrea8, Montoya Jenny8, Yaniz Mikael8, Petit Phar Pedro8, Filgueiras Christy8, Fernandez May8, Skrine Latauri8, Alcantara Aaliarys8, Parodis Isnier8, Parodis Jessica8, Jara Jailene8, Alouption Joslandey8, Yan Malvin8, Padilla Jesse8, Cruz Carolina8, Bran Bianca8, Flores Vanessa8, Perez Leandro8, Labovitz Arthur8, Roth Tracey8, Javier Julian8, Jimenez Lorenzo8, Ojeda Carmen8, Caceres Maria8, Misir Caren8, Rudd Kyle8, Ramos Juan8, Deeb Wasim8, Bisharat Mohannad8, Dennis-Saltz Amy8, Sutton David8, Magee James8, Ashchi Majdi8, Goldfaden Rebecca8, Sheikh-Ali Mae8, Kelly Stacey8, Nicolas Saikali Elias8, Rodel Ramirez Gloria8, Domingo Debbie8, Hodge William8, Greenewalt Adrienne8, Stamschror Lauren8, Preston Kaitlyn8, Petschonek Leann8, Graf Katie8, Sutton Lynsey8, Edson Meghan8, Charron Madison8, Taylor Mika8, Knisely Emily8, Gore Ashwini8, Jones Thomas8, Johns Barry8, Sheldon Jennifer8, Merritt Kayla8, Hichkad Lisa8, Barbee Leah8, Riley Amanda8, Alexander Lindsay8, Dasher Lilly8, Torres Lopez Elio Argimiro8, Baez Bonilla Rafael8, Loza Anibal8, Hernandez Dunia8, Perez Yaili8, Perez Alejandro8, Perez Yalily8, Medina Denisse8, Mantero Emilio8, Vega Ramses8, Pedraza Noel8, Sosa Damian8, Robles Lys8, Machado Yennifer8, Sosa Yoandra8, Guzman David8, Grio Maricor8, Frias Juan8, Kelly Sharon8, Leibowitz Mark8, Nelson John8, Handy Cheryll 8, Greenberg Alina8, Vega Norma8, Francisco Angelica8, Soto Coralia8, Arcadia Sinthia8, Francisco Eulalia8, Escareno Nicol8, Ayala Nelly8, Muniz Jennifer8, Espino Jose8, Vargas Daniel8, Jimenez Rosie8, Lopez Stephanie8, Gallaga Iliana 8, Heredia Genesis 8, Barranco Santana Elizabeth8, Mendoza-Rodriguez Rafael8, Cancel Santana Sara8, Román Alejandra8, Arroyo Torres Irmaris8, Franceschini Velma8, Garcia Brenda8, Jimenez Nancy8, Irizarry Ortiz Michele8, Torres Antommattei Armando8, Comulada-Rivera Angel8, Pintado Andrea8, Ortiz Sonia8, Rodriguez Adamaris8, Mojica Ramirez Rosa8, Olofintuyi Anthony8, Alvarez Ricardo8, Pitts Jay8, Samraj Jackelyn8, Vasbinder Alma8, Averett Amaya8, Kane Thomas8, Farley Harlicia8, Kendall Thomas8, Kemmerlin Richard8, Saunders Jackie8, Livingston Yolanda8, McLean Barry8, Mayer Maureen8, Goodwin Valerie8, Ngugi Evelyne8, Mishra Prateek8, Carter Hannah8, Szymela Lorie8, Imran Ali8, Abdallah Saiaf8, Clarke Nadia8, Hernandez Latog Sylvania8, Moore Broderick8, Lopez Miguel8, Tagsip Maureen8, Nepali Prakash8, Kumaran Nivi8, Jacinto Greta8, Magsino Catherine8, Batalla Freddie8, Imran Feroza8, Montgomery Richard8, Riggs Stephanie8, Haamid Shavonna8, Whitt Catherine8, Hopper William8, Smith Dominique8, Kordsmeier Julia8, Sherron Courtney8, Plummer Miyah8, Jimenez Sherisse8, Newkirk Airelle8, Murray Laura8, Scott Haley8, Whitney Rebecca8, Castro Monica8, Rhames Michelle8, Cortes-Maisonet Gregorio8, Miranda Martinez Luis8, Allende-Vigo Myriam8, Vila Karina8, Santiago Rivera Michelle8, Yunker Valerie8, Rivera Bryan8, Rodriguez Alex8, Rivera Carla8, Reyes Blanco Genesis8, Batista Colon Keven8, Cruz Mariely8, Nweke Chinedu8, Okafor Norah8, Nweke Angela8, Chaves-Montoya Daisy8, Patrick Heather8, Alvarez Stephanie8, Momeh Eunice8, Anaele Cyriacus8, McArthur Katherine8, Longonje Peter8, Husbands Danielle8, Williams Iasia8, Dillingham Christine8, Sanchez Sayyah Gloria8, Carey Laura8, Brock Clarissa8, Hussain Rubaba8, Sultana Khadiza8, Mohammad Omar8, Lopez Jennifer8, Bittencourt Valeria8, Prasad Sneha8, Akther Nafsun8, Smith Timothy8, Rocco Sheri8, Straatmann Donna8, Stoneman Jill8, Maryas Elizabeth8, Gravier Johanna8, Faggett Walter8, Jimenez Andres8, Maya Alvarez Maria8, Evora Wendy8, Herrera Alcira8, Leonardi Lorena8, Karns Adam8, Sisneros Edith8, Hong Sarom8, Rudyk Iurii8, Medentseva Olena8, Alexeeva Maryna8, Strakhova Nataliya8, Lozyk Tetyana8, Babichev Denys8, Yushko Kostiantyn8, Tseluyko Vira8, Zhadan Andriy8, Butko Olena8, Mishchenko Oksana8, Radchenko Olha8, Karpenko Oleksandr8, Klimko Polina8, Berezhniak Anna8, Todoriuk Liudmyla8, Bezuglova Svitlana8, Mitskevych Liubov8, Kizim Svitlana8, Nevolina Inna8, Galchenko Oksana8, Korzh Oleksii8, Pankova Olena8, Fylenko Yana8, Ziabchenko Valeriia8, Krasnokutskiy Sergiy8, Liashok Artem8, Donets Oleksandra8, Mishustina Anna8, Khrustalyova Liliya8, Donets Dmytro8, Rybachok Yuliia8, Senchylo Vyacheslav8, Lyakhova Iryna8, Takhaieva Olena8, Shkroba Anna8, Shchypak Diana8, Tryshchuk Nadiya8, Pieshkova Olga8, Karaia Olena8, Yakovleva Anna8, Horoshko Olha8, Lohdanidi Tetiana8, Belei Nestor8, Kuzmenko Inga8, Demchuk Tetiana8, Cherniuk Sergii8, Kozliuk Alina8, Kovalenko Volodymyr8, Adarichev Valerii8, Vakaliuk Igor8, Tymochko Nataliia8, Sovtus Volodymyra8, Haliuk Nadiia8, Gaudet Daniel8, Côté Fanny8, Milot Jean-Philippe8, Roy Nathalie8, Larouche Andrea8, Piché Johanne8, Charest Laurie-Anne8, Dufour Josiane8, Pageau Joannie8, Audet-Verreault Noemie8, Côté Lyne8, Gagnon Melissa8, Côté Véronique8, Morin Denise8, Fortin-Mimeault Jessica8, Brassard Marc-Olivier8, Gagne Helene8, Rousseau Sophie8, Sia Ying Tung8, Guzzetti Ezequiel8, Alejandro Gisbert Ramon8, Dias Mariana8, de Oliveira Mariana8, Cote Claudia8, Rodrigues Izabel8, Blanchard Johanne8, Labbe Laurence8, Dumoulin Lemay Sabrina8, Beauchemin Kathleen8, Turcotte Roxanne8, Beaudoin Annabelle8, Saliphod Chansamone8, Lamontagne Chantal8, Trudel Josiane8, Beaudoin Carolyne8, Blanchard Josée8, Larouche Annie8, Robinaud Cecile8, Paré Valérie8, Bergeron Alexandre8, Bilodeau Maude8, Bellavance Ethel8, Betit Eve8, Fortier Karine8, Racine Josee8, Perras Dinah8, Boulanger Elyse8, Beauchesne Christelle8, Lehoux Sarah8, Turgeon Vickie8, Cote Rachele8, Tardif Marie-Eve8, Aggarwal Naresh8, Aggarwal Puja8, Patel Bharti8, Dhaliwal Gurdeep8, Aggarwal Preeti8, Tellier Guy8, Gagne Gilbert8, Laperriere Luc8, Shalala Jennifer8, Danchuk Janelle8, Barrette Catherine8, Lauzon Lydia8, Langille Natalie8, Gagné Sarah8, Lupien Joanie8, Brochu Raphael8, Coallier Sophie8, Vaillancourt Catherine8, Lachance Pierre8, Carbonneau Diane8, Thibault Helene8, Bouchard Luc8, St-Cyr Andreanne8, Rioux Johanne8, Quenneville Laureanne8, Gagnon Constance8, Nony Theana8, Laberge Pascale8, Corbin Annabelle8, Patry Isabelle8, Savage Sophie8, MacNeil Melanie8, Murdock Andrea8, Inglis Jill8, Libbus Katelyn8, Smith Kathryn8, Johnson Deseray8, Walters-Findlay Linda8, Harris Laura8, Hutchison Taylor8, Rafuse Autumn8, Thorsen Julie8, MacDonald Greg8, Akhras Ronald8, Assef Richard8, Irani Elise8, Khayat Rania8, Guidolin Scott8, Gupta Anil8, Price David8, Gandhi Amisha8, Chhabra Ajay8, Gandhi Bhavya8, Acharya Shrey8, Panchal Maheshwari8, Kansal Bindu8, Bailey Gordon8, Harvalik Paula8, Demchuk Kerri8, Saxena Manish8, Collier David8, David Colvell8, Quiros Benildo Jr8, Patel Mital8, Balawon Armida8, Galera Francis8, Michalska Ania8, Piniera Brian8, Uddin Rahat8, Abbott Joanna8, Faulkner Karen8, Yousef Tamer8, Love Kyle8, Zagdanski Ariella8, Slaney Susan8, Anderson Michelle8, Leath Aimee8, Dunlop Cheryl8, Hardy Elizabeth8, Wall Shannon8, El-Koubani Osman8, Kelt Tracy8, Connolly Billy-Jean8, Marmion Cheryl8, Alapati Maheswari8, Simmons Louise8, Colquhoun Caroline8, Clyde Darren8, Mooty Adrian8, Mullen Nicole8, Viljoen Marianne8, Trevor Lucy8, Pretswell Carol8, Austin Catherine8, Munthali Chigomezgo8, Munsoor Imrozia8, Venkate Gowda Madhu8, Ozunlu Pembe8, Keighley Peter8, Jones Alison8, James Annette8, Pollitt Joanne8, Littlewood Wendy8, Al-Sheikhly Lena8, Lee David8, Nistor Denise8, Roberts Elaine8, Mawdsley Gayle8, Sobolewska Kamila8, Hannis Katrina8, Wojtkiewicz Klaudia8, Stopford Lauren8, Halliwell Lindsay8, Mort Veronica8, McGrath Victoria8, Osborne Harry8, Merrick Alison8, Basikolo Cathrine8, Ghysels Inge8, Fenlon Laura8, Beech Lucy8, Munoz Olga Lusquinos8, Bilton Sarah8, Goddard Lyne8, Gillon Tracey8, Taylor Stacy8, Tyson Brianne8, Connor Victoria8, Felber Hannah8, Fallows Angela8, Clowes Jacqueline8, Cheung Shirley8
Affiliation:
1. University of Chicago Medicine, Chicago, Illinois 2. Barts Health NHS Trust, London, United Kingdom 3. Queen Mary University of London, London, United Kingdom 4. Albion Finch Medical Centre, Toronto, Ontario, Canada 5. Clinical Neuroscience Solutions, Jacksonville, Florida 6. Alnylam Pharmaceuticals, Cambridge, Massachusetts 7. Cardiovascular Division, Brigham and Women’s Hospital, Boston, Massachusetts 8. for the KARDIA-1 Study Group
Abstract
ImportanceAngiotensinogen is the most upstream precursor of the renin–angiotensin–aldosterone system, a key pathway in blood pressure (BP) regulation. Zilebesiran, an investigational RNA interference therapeutic, targets hepatic angiotensinogen synthesis.ObjectiveTo evaluate antihypertensive efficacy and safety of different zilebesiran dosing regimens.Design, Setting, and ParticipantsThis phase 2, randomized, double-blind, dose-ranging study of zilebesiran vs placebo was performed at 78 sites across 4 countries. Screening initiation occurred in July 2021 and the last patient visit of the 6-month study occurred in June 2023. Adults with mild to moderate hypertension, defined as daytime mean ambulatory systolic BP (SBP) of 135 to 160 mm Hg following antihypertensive washout, were randomized.InterventionsRandomization to 1 of 4 subcutaneous zilebesiran regimens (150, 300, or 600 mg once every 6 months or 300 mg once every 3 months) or placebo (once every 3 months) for 6 months.Main Outcomes and MeasuresThe primary end point was between-group difference in least-squares mean (LSM) change from baseline to month 3 in 24-hour mean ambulatory SBP.ResultsOf 394 randomized patients, 377 (302 receiving zilebesiran and 75 receiving placebo) comprised the full analysis set (93 Black patients [24.7%]; 167 [44.3%] women; mean [SD] age, 57 [11] years). At 3 months, 24-hour mean ambulatory SBP changes from baseline were −7.3 mm Hg (95% CI, −10.3 to −4.4) with zilebesiran, 150 mg, once every 6 months; −10.0 mm Hg (95% CI, −12.0 to −7.9) with zilebesiran, 300 mg, once every 3 months or every 6 months; −8.9 mm Hg (95% CI, −11.9 to −6.0) with zilebesiran, 600 mg, once every 6 months; and 6.8 mm Hg (95% CI, 3.6-9.9) with placebo. LSM differences vs placebo in change from baseline to month 3 were −14.1 mm Hg (95% CI, −19.2 to −9.0; P < .001) with zilebesiran, 150 mg, once every 6 months; −16.7 mm Hg (95% CI, −21.2 to −12.3; P < .001) with zilebesiran, 300 mg, once every 3 months or every 6 months; and −15.7 mm Hg (95% CI, −20.8 to −10.6; P < .001) with zilebesiran, 600 mg, once every 6 months. Over 6 months, 60.9% of patients receiving zilebesiran had adverse events vs 50.7% patients receiving placebo and 3.6% had serious adverse events vs 6.7% receiving placebo. Nonserious drug-related adverse events occurred in 16.9% of zilebesiran-treated patients (principally injection site reactions and mild hyperkalemia) and 8.0% of placebo-treated patients.Conclusions and RelevanceIn adults with mild to moderate hypertension, treatment with zilebesiran across a range of doses at 3-month or 6-month intervals significantly reduced 24-hour mean ambulatory SBP at month 3.Trial RegistrationClinicalTrials.gov Identifier: NCT04936035
Publisher
American Medical Association (AMA)
Reference23 articles.
1. The preventable causes of death in the United States: comparative risk assessment of dietary, lifestyle, and metabolic risk factors.;Danaei;PLoS Med,2009 2. Global burden of hypertension and systolic blood pressure of at least 110 to 115 mm Hg, 1990-2015.;Forouzanfar;JAMA,2017 3. Cardiovascular disease, chronic kidney disease, and diabetes mortality burden of cardiometabolic risk factors from 1980 to 2010: a comparative risk assessment.;Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration;Lancet Diabetes Endocrinol,2014 4. Uncontrolled hypertension increases risk of all-cause and cardiovascular disease mortality in US adults: the NHANES III Linked Mortality Study.;Zhou;Sci Rep,2018 5. Assessment and management of blood-pressure variability.;Parati;Nat Rev Cardiol,2013
Cited by
21 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
|
|