Representativeness of Participants Eligible to Be Enrolled in Clinical Trials of Aducanumab for Alzheimer Disease Compared With Medicare Beneficiaries With Alzheimer Disease and Mild Cognitive Impairment

Author:

Anderson Timothy S.1,Ayanian John Z.23,Souza Jeffrey4,Landon Bruce E.4

Affiliation:

1. Division of General Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts

2. Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor

3. Editor, JAMA Health Forum

4. Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts

Publisher

American Medical Association (AMA)

Subject

General Medicine

Reference6 articles.

1. Evaluation of aducanumab for Alzheimer disease: scientific evidence and regulatory review involving efficacy, safety, and futility.;Alexander;JAMA,2021

2. Evaluation of Medicare claims data as a tool to identify dementia.;Lee;J Alzheimers Dis,2019

3. Centers for Medicare & Medicaid Services. Chronic Conditions Data Warehouse. Accessed July 10, 2021. https://www2.ccwdata.org/web/guest/condition-categories

4. ClinicalTrials.gov. 221AD302 Phase 3 Study of Aducanumab (BIIB037) in Early Alzheimer’s Disease (EMERGE). Accessed July 10, 2021. https://clinicaltrials.gov/ct2/show/NCT02484547

5. ClinicalTrials.gov. 221AD301 Phase 3 Study of Aducanumab (BIIB037) in Early Alzheimer’s Disease (ENGAGE). Accessed July 10, 2021. https://clinicaltrials.gov/ct2/show/NCT02477800

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