Intravenous Vitamin C for Patients Hospitalized With COVID-19-Reference-Cited by-同舟云学术

Intravenous Vitamin C for Patients Hospitalized With COVID-19

Published:2023-11-14 Issue:18 Volume:330 Page:1745
ISSN:0098-7484
Container-title:JAMA
language:en
Short-container-title:JAMA

Author:

,Florescu Simin ¹,Stanciu Delia¹,Zaharia Mihaela ¹, Kosa Alma¹,Codreanu Daniel¹,Fareed Komal¹,Kidwai Aneela¹,Kaye Callum¹,Coutts Amanda¹,MacKay Lynn¹,Summers Charlotte¹,Polgarova Petra ¹,Farahi Neda¹,Fox Eleonore¹,Sapsford David¹,Bongaerts Katherine¹,Featherstone Peter¹,Ng Anthony¹,McWilliam Stephen¹,Hawcutt Daniel¹,Rad Laura¹,O’Malley Laura¹,Whitbread Jennifer¹,Jones Dawn¹,Dore Rachael¹,Saunderson Paula ¹,Kelsall Olivia¹,Cowley Nicholas¹,Wild Laura¹,Thrush Jessica¹,Wood Hannah¹,Austin Karen¹,Donnelly Adrian¹,Kelly Martin¹,Smyth Naoise¹,O’Kane Sinéad¹,McClintock Declan¹,Warnock Majella¹,Campbell Ryan ¹,McCallion Edmund¹, Azaiz Amine¹,Charron Cyril¹,Godement Mathieu¹,Geri Guillaume¹,Vieillard-Baron Antoine¹,Johnson Paul¹,McKenna Shirley¹,Hanley Joanne¹,Currie Andrew¹,Allen Barbara¹,McGoldrick Clare ¹,McMaster Moyra¹,Mani Ashwin¹,Mathew Meghena¹,Kandeepan Revathi¹,Vignesh Chandrashekar¹,Ramakrishnan Nagarajan¹,James Augustian ¹,Elvira Evangeline¹,Pratheema Ramachandran¹,Babu Suresh¹,Ebenezer Rabindrarajan¹,Krishnamoorthy S¹,Ranganathan Lakshmi¹,Ganesan Manisha¹,Shree Madhu¹,Piva Simone¹,Focà Emanuele¹,Rizzoni Damiano¹,Boari Gianluca¹,Marchesi Mattia¹,Butler Magdalena¹,Cowdrey Keri-Anne¹,Mason Brittany¹,Woolett Melissa¹,Duffy Eamon¹,Chen Yan¹,Nakamuro Hiromi¹,O’Connor Caroline¹,West Lauren¹,El-Khawas Khaled¹,Richardson Angus¹,Hill Dianne¹,Commons Robert¹,Abdelkharim Hussam¹,Saxena Manoj¹,Muteithia Margaret¹,Dobell-Brown Kelsey¹,Jha Rajeev¹,Kalogirou Michael¹,Ellis Christine¹,Krishnamurthy Vinodh¹,O’Connor Aibhilin¹,Thurairatnam Saranya¹,Mukherjee Dipak¹,Kaliappan Agilan¹,Vertue Mark¹,Nicholson Anne¹,Riches Joanne¹,Maloney Gracie¹,Kittridge Lauren¹,Solesbury Amanda¹,Ramos Angelo¹,Collins Daniel¹,Brickell Kathy¹,Reid Liadain¹,Smyth Michelle¹,Breen Patrick¹,Spain Sandra¹,Curley Gerard¹,McEvoy Natalie¹,Geoghegan Pierce¹,Clarke Jennifer¹,Silversides Jon¹,McGuigan Peter¹,Ward Kathryn¹,O’Neill Aisling¹,Finn Stephanie¹,Wright Chris¹,Green Jackie¹,Collins Érin¹,Major Emmet¹,McAuley Julie¹,Carter Angus¹,Smith Julie¹,Boschert Catherine¹,Slieker Kitty¹,Ewalds Esther¹,Sanders Arnate¹,Wittenberg Wendy¹,Geurts Heidi¹,Poojara Latesh¹,Sara Treena¹,Nand Kiran¹,Reeve Brenda¹,Dechert William¹,Phillips Barbara ¹,Oritz-Ruiz de Gordoa Laura¹,Campbell Marion¹,Dos Santos Filipa¹,Hansen Dan¹,Mullan Dee¹,Affleck Julia¹,Shaikh Arif¹,Murray Andrew¹,Ramanan Mahesh¹,Frakking Thuy¹,Pinnell Jez¹,Robinson Matt ¹,Gledhill Lisa¹,Wood Tracy¹,Sanghavi Ritesh¹,Bhonagiri Deepak¹,Ford Megan¹,Parikh Harshel G.¹,Avard Bronwyn¹,Nourse Mary¹,McDonald Bree¹,Edmunds Natasha¹,Hoiting Oscar¹,Peters Marco¹,Rengers Els¹,Bindels Manon¹,Evers Mirjam¹,Prinssen Anton¹,Morgan Matt¹,Cole Jade ¹,Hill Helen¹,Davies Michelle¹,Williams Angharad ¹,Thomas Emma¹,Davies Rhys¹,Wise Matt¹,Law Daniel¹,Grimm Patrick¹,Soukup Jens¹,Wetzold Richard¹,Löbel Madlen¹,Starke Lisa¹,Lellouche Francois ¹,Lizotte Patricia¹,Auvet Adrien¹,Ravry Celine¹,Creange Vanessa¹,Boivin Anne-Helene¹,Barreau Amélie¹,Vandewoestyne Sophie¹,Declercq Pierre-Louis¹,Marchalot Antoine¹,Saladin Cecile¹,Gelinotte Stephanie¹,Eraldi Jean-Pierre¹,Bourgerol François¹,Beuzelin Marion¹,Jean-Philippe Rigaud¹,Pourcine Franck¹,Monchi Mehran¹,Pradel Gael¹,Hausermann Marie-Helene¹,Boudineau Michel¹,Nguyen-Valat Thi-My-Hue¹,Guitton Christophe¹,Marnai Remy¹,Leroyer Marie-Helene¹,Landais Michaël¹,Darreau Cedric¹,Saint Martin Marjorie¹,Tirot Patrice¹,Chudeau Nicolas¹,Brasselet Aurélie¹,Volkov Lev¹,Callahan Jean-Christophe¹,Meunier Juliette¹,Douillard Thomas¹,Le Basnier Elliot¹,Veillard Marion¹,Vivier Dominique¹,Luis David¹,Mercier Romain¹,Sagnier Anne¹,Verrier Nathalie¹,Caplin Cecile¹,Richecoeur Jack¹,Combaux Daniele¹,Siami Shidasp¹,Aparicio Christelle¹,Vautier Sarah¹,Jeblaoui Asma¹,Lemaire-Brunel Delphine¹,D’Aragon Frédérick¹,Bérard Dominique¹,Grondin-Beaudoin Brian¹,Leclair Marc-André¹,Lesur Olivier¹,Mayette Michaël¹,Poulin Yannick¹,Quiroz-Martinez Hector¹,St-Arnaud Charles¹,Carbonneau Elaine¹,Bolduc Brigitte¹,Bélisle Julie¹,Bouchard Marie-Pier¹,Côté Line¹,Martineau Joannie¹,Naisby Alexandra¹,Robert-Petit Louise¹,Thibault Marie-Ève¹,Leblond Julie¹,Plantefeve Gaetan ¹,Leparco Cécile¹,Contou Damien¹,Fartoukh Muriel¹,Courtin Laura¹,Labbe Vincent¹,Voiriot Guillaume¹,Salhi Sara¹,Chassé Michaël¹,Pierre Aslanian¹,Bélisle Sylvain¹,Carrier François Martin¹,Charbonney Emmanuel¹,Girard Martin¹,Guimond Jean-Gilles¹,Halwagi Antoine¹,Kolan Christophe¹,Robillard Nicholas¹,Boumahni Dounia ¹,Benettaib Fatna¹,Cantin Marie-Ève¹,Coutu-Beaudry Katherine¹,Ghamraoui Ali¹,Lamothe Francesca¹,Lebrasseur Martine¹,Prie Cindy¹,Salamé Maya¹,Archambault Patrick¹,Côté Émilie¹,Beaudoin Rosalie¹,Noel-Hunter Monia¹,Boutin Mireille¹,Couture Laurie¹,Sement Arnaud¹,Gachet Alexandre¹,Hanisch Alexis¹,Haffiane Abdelmagid¹,Boivin Anne-Hélène¹,Barreau Amelie¹,Guerineau Elodie¹,Poupblanc Séverine¹,Egreteau Pierre-Yves¹,Lefevre Montaine¹,Bocher Simon¹,Le Loup Guillaume¹,Le Guen Lenaïg¹,Carn Vanessa¹,Bertel Melanie¹,Antcliffe David¹,Templeton Maie ¹,Rojo Roceld¹,Coghlan Phoebe¹,Smee Joanna ¹,Barker Gareth¹,Finn André¹,Kreß Gabriele¹,Hoff Uwe¹,Hinrichs Carl¹,Nee Jens¹,Mackay Euan ¹,Cort Jon¹,Whileman Amanda¹,Spencer Thomas¹,Spittle Nick¹,Beavis Sarah¹,Padmakumar Anand¹,Dale Katie¹,Hawes Joanne¹,Moakes Emma¹,Gascoyne Rachel ¹,Pritchard Kelly¹,Stevenson Lesley¹,Cooke Justin¹,Nemeth-Roszpopa Karolina¹,Adhikari Sheetal¹,Gauli Basanta¹,Kunwar Puja¹,Muller Grégoire¹,Nay Mai-Anh¹,Kamel Toufik¹,Benzekri Dalila¹,Jacquier Sophie¹,Runge Isabelle¹,Mathonnet Armelle¹,Barbier François¹,Bretagnol Anne¹,Carter Jay¹,Van Der Heyden Kymbalee¹,Mehrtens Jan¹,Morris Anna¹,Morgan Stacey¹,Burke Tara¹,Mercier Emmanuelle¹,Chartier Delphine¹,Salmon Charlotte¹,Dequin Pierre-François¹,Garot Denis¹,Quenot Jean Pierre¹,Garrier Ludivine¹,Villot Solenne¹,Audry Mathilde¹,Brassard Eric¹,Francoeur Charles¹,Lauzier François¹,Leblanc Guillaume¹,St-Onge Maude¹,Bellemare David¹,Cloutier Ève ¹,Daher Rana ¹,Costerousse Olivier¹,Boulanger Marie-Claude¹,Couillard-Chénard Émilie¹,Mallard Louis-Charles¹,Thibeault Frédérique¹,Tremblay Antoine¹,Francois Bruno¹,Gay Alexandra¹,Anne-Laure Fedou¹,Ramali Mohamed¹,HC Ooi¹,Ghosh Alison¹,Osagie Rawlings¹,Arachchige Malka¹,Hartley Melissa¹,Shu Ki Lok Jennifer¹,Plummer Bethany¹,Hin Lui Lok¹,Bloomfield Jack¹,Balls-Burgess Sam¹,Seigne Patick¹,Philip Annlin¹,Cleary Joanne¹,O'Neill Lorraine¹,Kelly Niamh¹,Bamford Peter¹,Reid Andrew¹,Cawley Kathryn¹,Faulkner Maria¹,Pickering Charlotte¹,Raj Ashok ¹,Tsinaslanidis Georgios¹,Khade Reena ¹,Agha Gloria¹,Sekiwala Rose¹,Smith Tim¹,Brewer Chris¹,Gregory Jane¹,Limb James¹,Cowton Amanda¹,O’Brien Julie¹,Postlethwaite Kelly¹,Malakouti Salim¹,Music Edvin¹,Ricketts Dan¹,King Andrew¹,Clermont Gilles¹,Bart Robert¹,Mayr Florian¹,Schoenling Andrew¹,Andreae Mark¹,Shetty Varun¹,Brant Emily¹,Malley Brian¹,Donadee Chenell¹,Horvat Christopher¹,Girard Timothy¹,Sackrowitz Rachel¹,Weissman Alexandra¹,Yealy Donald¹,Barton David¹,Talia Nadine¹,Nikitas Nikitas¹,Wells Colin¹,McMillan Helen¹,Stowe Bethan¹,Spencer Kayleigh¹,Stapleton Liana¹,van den Oever Huub¹,Kruisdijk-Gerritsen Arriette¹,Haidar Ghady ¹,Bain William¹,Barbash Ian¹,Fitzpatrick Meghan¹,Kitsios Georgios¹,Moghbeli Kaveh¹,Rosborough Brian¹,Shah Faraaz¹,Suber Tomeka¹,Stanley Timothy¹,Castle James¹,Carr Zoe¹,Alegria Ana¹,Turki Salah¹,Elsefi Tarek¹,Crisp Nikki¹,Allen Louise¹,Truman Nicholas¹,Smith Matthew¹,Chukkambotla Sri¹,Goddard Wendy¹,Duberley Stephen¹,Khan Meherunnisa¹,Kazi Aayesha¹,Simpson Joanna¹,Duke Graeme¹,Chan Peter¹,Carter Brittney¹,Hunter Stephanie¹,Voigt Ingo¹,Schueler Robert¹,Blank Elisabeth¹,Hüning Vanessa¹,Steffen Melanie¹,Goralski Patricia¹,Regli Adrian¹,Pellicano Susan¹,Palermo Annamaria¹,Eroglu Ege¹,Bihari Shailesh¹,Laver Russell D.¹,Shrestha Tapaswi¹,Jin Xia¹,McIntyre Joanne¹,McCullagh Iain¹,Cairns Tom¹,Hanson Helen¹,Patel Bijal¹,Clement Ian¹,Evetts George¹,Touma Omar ¹,Holland Susan¹,Hodge Christopher¹,Taylor Holly¹,Alderman Meera¹,Barnes Nicky¹,Da Rocha Joana¹,Smith Catherine¹,Brooks Nicole¹,Weerasinghe Thanuja¹,Sinclair Julie-Ann¹,Abusamra Yousuf¹,Doherty Ronan¹,Cudlipp Joanna ¹,Singh Rajeev¹,Yu Haili¹,Daebis Admad ¹,NG Christopher¹,Kendrick Sara ¹,Saran Anita¹,Makky Ahmed ¹,Greener Danni¹,Rowe-Leete Louise¹,Edwards Alexandra¹,Bland Yvonne¹,Dolman Rozzie¹,Foster Tracy¹,Conway Robert¹,Csabi Peter¹,Szawarski Piotr¹,Hajdu Bence¹,Tamm Tina¹,Bryden Emma¹,Glynou Loukia¹,Graniewski Jaroslaw¹,Kuybida Yuriy¹,Jones Samantha¹,Kavanagh Lisa¹,Singler Karen¹,Laffey John¹,McNicholas Bairbre¹,Scully Michael¹,Casey Siobhan ¹,Kernan Maeve¹,Brennan Aoife¹,Rangan Ritika¹,Tully Riona¹,Corbett Sarah¹,McCarthy Aine ¹,Duffy Oscar¹,Burke David¹,Linnett Vanessa¹,Sanderson Amanda¹,Ritzema Jenny¹,Wild Helen¹,Lucas Rachael¹,Marriott Yvonne¹,Khare Divya¹,Pinder Meredith¹,Gopinath Amitha ¹,Kannan Thogulava¹,Dean Steven¹,Vanmali Piyush¹,Depuydt Pieter¹,De Waele Jan¹,De Bus Liesbet¹,Fierens Jan¹,Bracke Stephanie¹,Vermassen Joris¹,Vermeiren Daisy¹,Van Hecke Jolien¹,De Smeytere Anouska¹,Pugh Richard¹,Lean Richard¹,Qiu Xinyi¹,Scanlan Jeremy¹,Evans Andrew¹,Davies Gwyneth¹,Lewis Joanne¹,Rees Stephanie¹,MacKay Callum¹,Craddock Richard¹,Davies Jennifer¹,Williams Hannah¹,Manley Rachel¹,Garrod Esther¹,Tee Ameilia¹,Plesnikova Yvonna¹,Khoud Ahmed¹,Coetzee Samantha¹,Puxty Kathryn¹,Cathcart Susanne¹,Rimmer Dominic¹,Bagot Catherine¹,Scott Kathryn¹,Martin Laila¹,MacTavish Pamela¹,Murphy Ryan¹,Carmichael Samantha¹,Tait Jennifer¹,Nygren Maria¹,Yusuff Hakeem¹,Isgro Graziella¹,Brightling Chris¹,Bourne Michelle¹,Craner Michelle¹,Boyles Rebecca¹,Alexander Brian¹,Roberts Tracey¹,Nelli Apoorva¹,Rosenstein-Sisson Rachel¹,Speyer Rebecca¹,Pech Yadira¹,McCullough James¹,Tallott Mandy¹,Vazquez-Grande Gloria¹,Marten Nicole¹,Liu Theresa¹,Siddiqui Atif¹,Khanal Sushil¹,Amatya Sameena¹,Shrestha Sabita¹,Pathak Shreya¹,Mali Sharmila¹,Bhattarai Bina¹,Szakmany Tamas ¹,Cherian Shiney¹,Williams Gemma¹,James Christie¹,Waters Abby¹,Duric Natalie¹,Almeshhedani Hasham¹,Jesty Robert¹,Spiers Catriona¹,Prout Rachel¹,Stedman Roger¹,Davies Louisa¹,Pegler Suzannah¹,Kyeremeh Lynsey¹,Moorhouse Louise¹,Watters Malcolm¹,Arbane Gill¹,Bociek Aneta¹,Ostermann Marlies¹,D’Amato Fabiola¹,GrauNovellas Neus¹,Mathew Moncy¹,Lim Rosario¹,van Nieuwkoop Kees¹,Ottens Thomas¹,Visser Yorik¹,van den Berg Lettie ¹,van der Kraan-Donker Annemarie¹,Meade Maureen¹,Belley-Côté Émilie¹,Hand Lori¹,Brett Stephen¹,Arias Sonia ¹,Hall Rebecca¹,Paneru Hem¹,Koirala Sabin¹,Paudel Pratibha¹,Shakya Roshni¹,Kayastha Srijana¹,Karki Rakshya¹,Wilson Maggie¹,Vaara Suvi¹,Pettilä Leena¹,Heinonen Jonna¹,Pettilä Ville¹,Jain Susan¹,Gupta Abhinav¹,Holbrook Catherine ¹,Antoine Pierre¹,Meziani Ferhat¹,Allam Hayat¹,Cattelan Jessy¹,Clere-Jehl Raphael¹,Helms Julie¹,Kummerlen Christine¹,Merdji Hamid¹,Monnier Alexandra¹,Rahmani Hassene¹,Antoine Studer¹,Schneider Francis¹,Castelain Vincent¹,Morel Guillaume¹,L’Hotellier Sylvie¹,Ochin Evelina¹,Vanjak Christian¹,Rouge Patrick¹,Bendjemar Lynda¹,Albert Martin¹,Serri Karim¹,Cavayas Alexandros¹,Duplaix Mathilde¹,Williams Virginie¹,Catorze Nuno José Teodoro Amaro dos Santos¹,Pereira Tiago Nuno Alfaro Lima¹,Ferreira Ricardo Manuel Castro¹,Bastos Joana Margarida Pereira Sousa¹,Batista Teresa Margarida Oliveira¹,Badie Julio¹,Berdaguer Fernando¹,Malfroy Sylvain¹,Mezher Chaouki¹,Bourgoin Charlotte¹,Moneger Guy¹,Bouvier Elodie¹,Muñoz-Bermúdez Rosana¹,Marin-Corral Judith¹,Degracia Anna¹,Gómez Francisco¹,López Maria¹,Pérez-Terán Purificación¹,Vilá Clara¹,Bigas Judit¹,Roche-Campo Ferran¹,Franch-LLasat Diego¹,Concha Pablo¹,Domingo-Marco Joana¹,Reverté-Villarroya Silvia¹,Sauras-Colón Esther¹,Masdeu-Eixarch Gaspar¹,Aceto Romina¹,Aghemo Alessio¹,Badalamenti Salvatore¹,Brunetta Enrico¹,Ciccarelli Michele¹,Constantini Elena¹,Greco Massimiliano¹,Folci Marco¹,Selmi Carlo¹,Voza Antonio¹,Occhipinti Giovanna¹,Constantino Claudia¹,Cuffaro Raffaele¹,Russelli Giovanna¹,Martucci Gennaro¹,Landoni Giovanni¹,Aldo Bonizzoni Matteo¹,Galbiati Carola¹,Nakhnoukh Cristina¹,Lembo Rosalba¹,Mascherpa Glenda¹,Giardina Giuseppe¹,Belletti Alessandro¹,Ripa Marco¹,Rovere-Querini Patrizia¹,Di Lucca Giuseppe¹,Bonaccorso Alessandra¹,Alessandro Carà Gianmarco¹,Russo Giada¹,Salvati Stefano¹,Tomasi Enrico¹,Henning Jeremy¹,Bonner Stephen¹,Hugill Keith¹,Cirstea Emanuel ¹,Wilkinson Dean¹,Jones Jessica¹,Altomy Mohammed¹,Headlam Evie¹,Karlikowski Michal¹,Sutherland Helen¹,Wilhelmsen Elva¹,Woods Jane¹,North Julie¹,Brodbeck Andreas¹,Mackintosh Katherine¹,Garvey James¹,Bothma Pieter¹,Tupper-Carey Daryl¹,Ikhena Ikhuemose¹,Osborne Jason¹,Waugh Victoria¹,Pletz Mathias¹,Hagel Stefan¹,Ankert Juliane¹,Kolanos Steffi¹,Bloos Frank¹,Simons Koen¹,van Zuylen Tamara¹,Bouman Angela¹,Kumar Nikhil¹,Panwar Rakshit¹,Poulter Amber-Louise¹,Sunkara Krishna¹,Rochwerg Bram¹,Karachi Tim¹,Oczkowski Simon¹,Centofanti John¹,Millen Tina¹,Camargo Mercedes¹,Khaled Alia¹,Sundaran Dhinesh¹,Hollos Laszlo¹,Williams Anna¹,Turns Margaret ¹,Walsh Joanne ¹,Al Qasim Eman¹,Alswaidan Lolowa¹,Hegazy Mohamed¹,Arishi Hatim¹,Al Amri Ali¹,AlQahtani Samah¹,Naidu Brintha¹,Tlayjeh Haytham¹,Hussain Sajid¹,Al Enezi Farhan¹,Abdukahil Sheryl Ann¹,Hopkins Phil¹,Smith John¹,Noble Harriet ¹,O’Reilly Kevin¹,Mehta Reena¹,Wong Onyee ¹,Makanju Esther¹,Rao Deepak¹,Sikondari Nyma ¹,Saha Sian¹,Corcoran Ele¹,Pappa Evita¹,Cockrell Maeve¹,Donegan Clare¹,Balaie Morteza¹,Depante Maria¹,Nickoleit-Bitzenberger Daniela¹,Schaaf Bernhard¹,Meermeier Werner¹,Prebeg Katharina¹,Azzaui Harun¹,Hower Martin¹,Brieger Klaus-Gerd¹,Elender Corinna¹,Sabelhaus Timo¹,Riepe Ansgar¹,Akamp Ceren¹,Kremling Julius¹,Klein Daniela¹,Landsiedel-Mechenbier Elke¹,Laha Shondipon¹,Verlander Mark¹,Williams Alexandra¹,Jha Avinash¹,Megarbane Bruno¹,Voicu Sebastian¹,Deye Nicolas¹,Malissin Isabelle¹,Sutterlin Laetitia¹,Mrad Aymen¹,Lehalleur Adrien¹,Naim Giulia¹,Nguyen Philippe¹,Ekhérian Jean-Michel¹,Boué Yvonnick¹,Sidéris Georgios¹,Vodovar Dominique¹,Guérin Emmanuelle¹,Grant Caroline¹,Brain Matthew¹,Mckeon Laurie¹,Chen Lixian¹,Tresize Tarnya¹,Unwin Maria¹,Laugs Fabian¹,Lunde Ragnar¹,Blanck Wendy¹,Paramasivam Elankumaran¹,Wilby Elizabeth¹,Ogg Bethan¹,Howcroft Clare¹,Aspinwall Angelique¹,Charlton Sam¹,Gould Richard¹,Mistry Deena¹,Awan Sidra¹,Bedford Caroline¹,Carr-Wilkinson Joanne ¹,Hall Andrew¹,Cooke Jill¹,Gardiner-Hill Caroline¹,Maloney Carolyn¹,Brunskill Nigel¹,Watchorn Olivia¹,Hardy Chloe¹,Qureshi Hafiz¹,Flint Neil¹,Nicholson Sarah¹,Southin Sara¹,Nicholson Andrew¹,Ghattaoraya Amardeep¹,Harding Daniel¹,O’Halloran Sinead¹,Collins Amy¹,Smith Emma¹,Trues Estefania¹,Borgatta Barbara¹,Turner-Bone Ian¹,Reddy Amie¹,Wilding Laura¹,Wilson Craig¹,Surti Zuhra¹,Aneman Anders¹,Dugan Christopher¹,Chin Edison¹,Miller Jennene¹,White Hayden¹,Estensen Kristen¹,Morrison Lynette¹,Sutton Joanne¹,Cooper Melanie¹,Warnapura Loku¹,Agno Ronan¹,Sathianathan Prasannakumari ¹,Shaw Deborah¹,Ijaz Nazia¹,Spong Adam¹,Sabaretnam Suganya¹,Burns Dean¹,Lang Eva¹,Tate Margaret¹,Fischer Roy¹,Biradar Vishwanath¹,Soar Natalie¹,Golden David¹,Davey Miriam¹,Seaman Rebecca¹,Osborne Alexander¹,Bannard-Smith Jonathan¹,Clark Richard¹,Birchall Kathrine¹,Henry Joanne¹,Pomeroy Fiona¹,Quayle Rachael¹,Wylie Katharine¹,Sukuraman Anila¹,John Maya¹,Sibin Sindhu¹,Leditschke Anne¹,Finnis Mackenzie¹,Jongebloed Katherine¹,Roumen Rudy¹,de Groot Klaas¹,Khwaja Kosar¹,Campisi Josie¹,van Vonderen Marit¹,Stienstra Riejanne¹,Kampschreur Linda¹,Pietersma Mario¹,van Gulik Laura¹,Makowski Arystarch¹,Misztal Beata¹,Haider Syeda¹,Liao Angela¹,Squires Rebecca¹,Oborska Aneta¹,Kayani Abdul¹,Kalchko-Veyssal Selver¹,Prabakaran Rajalakshmi¹,Hadebe Bernard¹,Williams Tony¹,Song Rima¹,Girijadevi Dinuraj¹,Lai Vivian¹,Morpeth Susan¹,Mwembani Tina¹,Stewart Richard¹,Mwaura Esther¹,Mew Louise¹,Wren Lynn¹,Willams Felicity¹,Sutherland Sara-Beth¹,Rebello Rashmi¹,Rehman Atique¹,Bharaj Kiranjit¹,Shehabi Yahya¹,Al-Bassam Wisam¹,Hulley Amanda¹,Kadam Umesh¹,Sathianathan Kushaharan¹,Burgess Richard¹,Doble Patricia¹,Graham Libby¹,Shovelton Charmaine¹,Dean Tessa¹,Purnell Rebecca¹,Thomas Ashly¹,Masood Sobia¹,Salahuddin Nawal¹,Khanal Kishor¹,Dheke Krishan¹,Rai Namrata¹,Maharjan Mili¹,Aryal Diptesh¹,Koirala Kanchan¹,Luitel Subekshya¹,Seppelt Ian¹,Whitehead Christina¹,Lowrey Julie¹,Gresham Rebecca¹,Masters Kristy¹,Hamlyn Vincent¹,Hawkins Nancy¹,Roynon-Reed Anna¹,Cutler Sean¹,Lewis Sarah¹,Martin-Lazaro Juan¹,Newman Tabitha¹,Zdanavidiene Ausra¹,Smallshaw Karen¹,Hand James¹,Aravindan Latha¹,Asghar Adeeba¹,Bartholomew Jazz¹,Bayne Madeleine¹,Beddows Seonaid¹,Birch Catherine¹,Brend Morwenna¹,Byrne Rahim¹,Campbell Debbie¹,Campbell Hilary¹,Chambers Emma¹,Clinton Alison¹,Collins Joanne¹,Crawshaw Sarah¹,Dawson Laura Ann¹,Donaldson Kate¹,Drake Chelsea¹,Dyas Sarah¹,Ellis Yvette¹,Gilmour Kate¹,Goodwin Jayne¹,Halden Sandra¹,Hall Alistair S¹,Hanson Jane¹,Harper Heather¹,Harrison Susan¹,Hayes Amber¹,Hodgson Helen¹,Hurford Sally-Anne¹,Jackson Shane¹,Levett Chris¹,Lock Stephen¹,Lockett Teresa¹,Logan Meg¹,Lomme Kaatje¹,Luo Ji¹,Marsh Emma¹,McKenna Sonia¹,Mguni Nhlanhla¹,Monaghan Holly¹,Murphy Sheenagh¹,Muzengi Natasha¹,Naz Mobeena¹,O'Kell Eleanor¹,Oliver Anne¹,O'Reilly Joanna¹,Pearson Karen¹,Porter David¹,Potter Alison¹,Rook Clare¹,Rounds Charles¹,Sheffield Jonathan¹,Shirley Kim¹,Siewerski Chris¹,Skinner Tabitha¹,Speight Holly¹,Sutu Mihaela¹,Unsworth Adam¹,Van’t Hoff William¹,Walker Susan¹,Williams Penny¹,Williamson Dawn¹,Williamson James D¹,Tsang Jennifer¹,Duan Erick¹,Ali Karim¹,Farjou George¹,Chung Han-Oh¹,Jensen Lorraine¹,Patterson Lisa¹,Nielsen-Smith Diane¹,Becevel Julia¹,Cavers Christine¹,Ding Josephine¹,irish Jamie¹,Jomy Jane¹,Austin Pauline¹,Chapman Susan¹,Cabrelli Louise¹,Fletcher Simon¹,Nortje Jurgens¹,Fottrell-Gould Deirdre¹,Randell Georgina¹,Stammers Katie¹,Healey Gail¹,Pinto Marta¹,Woodward Robert¹,Oliver Martyn¹,Harvey James¹,Convery Karen¹,Brown Zarah¹,Taylor Sian¹,Fraser Catherine¹,Glister Georgina¹,Hindle Grace¹,O Rourke Kate¹,Borrill Zoe¹,Duncan Tracy¹,Ustianowski Andrew¹,Uriel Alison¹,Eltayeb Ayaa¹,Alfonso Jordan¹,Hey Samuel¹,Shaw Joanne¹,Fox Claire¹,Lindergard Gabriella¹,Charles Bethan¹,Blackledge Bethany¹,Connolly Karen¹,Harris Jade¹,Cuesta Jeronimo¹,Xavier Kugan¹,Purohit Dharam¹,Elhassan Munzir¹,Haldeos Anne¹,Vincent Rachel¹,Abdelrazik Marwa¹,Jenkins Samuel¹,Ganesan Arunkumar¹,Kumar Rohit¹,Carter David¹,Bakthavatsalam Dhanalakshmi¹,Frater Alasdair¹,Saleem Malik¹,Madarbukus Daanyaal¹,Everitt Robert¹,Bridges Sarah¹,Karim Hina¹,Zaman Mohsin¹,Elmahi Einas¹,Jones Andrea¹,Hall Kathryn¹,Phillips Matt¹,Terrill Lenae¹,Mills Gary¹,Raithatha Ajay¹,Bauchmuller Kris¹,Ryalls Kim¹,Harrington Kate¹,Bowler Helen¹,Sall Jas¹,Bourne Richard¹,Howell Alice¹,Lye Alison¹,Kirk Rosemary¹,Jarman Claire¹,Yates Bryan¹,Kilner Mari¹,Bomken Charlotte¹,Reynolds Jessica¹,Gross Jamie¹,Massey Natalie¹,Adebambo Olumide¹,Long Matilda¹,Tony Kiran¹,Kohli Sonny¹,Cui Fulan¹,Khera Vikas¹,Rehsia Sachdeep¹,Perez Adic¹,Bharti Dalisha¹,Handa Surbhi¹,Shields Fiona¹,Henschke Alice¹,Juffermans Nicole¹,Koopmans Matty¹,Rowland Matthew¹,Hutton Paula¹,Bashyal Archana¹,Davidson Neil¹,Hird Clare¹,Beer Sally¹,Wilson Jean¹,Polley Grace¹,Chhablani Manish¹,Phalod Gunjan¹,Kirkby Amy¹,Archer Simon¹,Netherton Kimberley ¹,Reschreiter Henrik¹,Camsooksai Julie¹,Patch Sarah¹,Jenkins Sarah¹,Humphrey Charlotte¹,Langridge Emma¹,Flynn Gordon¹,Harrington Claire¹,Kruger Peter¹,Walsham James¹,Meyer Jason¹,Harward Meg¹,Mackay Josephine¹,Jones Cassie¹,Sathe Sonia¹,Roche Lisa¹,Davies Ellie¹,Skinner Denise¹,Gaylard Jane¹,Newman Julie¹,Pogson David¹,Rose Steve¹,Daly Zoe¹,Brimfield Lutece¹,Nown Angie¹,Parekh Dhruv¹,Bergin Colin¹,Bates Michelle¹,McGhee Christopher¹,Lynch Daniella¹,Bhandal Khushpreet¹,Tsakiridou Kyriaki¹,Bamford Amy¹,Cooper Lauren¹,Whitehouse Tony¹,Veenith Tonny¹,Forster Elliot¹,O'Connell Martin¹,Page Shannon¹,Haider Nafeesah¹,Adams Nick¹,Sim Malcolm¹,Hay Sophie¹,Henderson Steven¹,Valentine Eliza¹,Ralston Maximillian¹,McCreath Gordan¹,Arnott Andrew¹,Orlikowska Izabela¹,Parker Natasha¹,Katary Amro¹,Bell Gillian¹,Wilcox Louise¹,Mataliotakis Michail¹,Smith Paul¹,Ali Murtaza¹,Isguzar Agah¹,Phull Mandeep-Kaur¹,Zaidi Abbas¹,Pogreban Tatiana¹,Rosaroso Lace¹,O’Brien Neale¹,Visentin Elisa¹,Harvey Daniel¹,Lowe Benjamin¹,Meredith Megan¹,Ryan Lucy¹,Clark Amy¹,Peters Cecilia¹,Walton Catherine¹,Joseph Treesa¹,Gibbins Alexandra¹,Sampson Julia¹,Morris Lucy¹,Dent Martin¹,Haghi Theerata¹,Schouten Jeroen¹,Pickkers Peter¹,Roovers Noortje¹,Klop-Riehl Margreet¹,van der Eng Hetty¹,van de Veerdonk Frank¹,Sloots-Cuppen Sonja¹,Preijers Lieke¹,Polfliet Margot¹,Heming Nicholas¹,Moine Pierre¹,Maxime Virginie¹,Bossard Isabelle¹,Nicholier Tiphaine¹,Clair Bernard¹,Orlikowski David¹,Bounab Rania¹,Abdeladim Lilia¹,Baker Stuart¹,Tabah Alexis¹,Duroux Maree¹,Ratcliffe Megan¹,Sy Eric¹,Mailman Jonathan¹,Lee Stephen¹,Kassir Sandy¹,England Jenna¹,López Rafael¹,Rodríguez-Gómez Jorge¹,Cárcel Sheila¹,Carmona Rosario¹,de la Fuente Carmen¹,Rodriguez Marina¹,de la Torre Cisneros Julian¹,Jan Hassing Robert ¹,Greven Frances¹,Huijbens Danique¹,Verheij Harald¹,Roebers L¹,Miles Helen¹,Attokaran Antony¹,Buehner Ulrike¹,Williams Erin¹,Plummer Mark¹,O’Connor Stephanie¹,Glasby Kathleen¹,Rivett Justine¹,Brown Nerissa¹,Kutsogiannis Demetrios¹,Chowdhury Raiyan¹,Davidow Jon¹,Johnston Curtis¹,Kim Michael¹,Macala Kimberley ¹,Markland Darren¹,Matheson Doug¹,Parker Arabesque¹,Paton-Gay Damian¹,Robinson Andrea¹,Thompson Patrica¹,Hewer Tayne¹,Rooney Kevin¹,Rodden Natalie¹,Thomson Nicola¹,McGlynn Deborah¹,Abel Lynn¹,Gemmell Lisa¹,Sundaram Radha¹,Hornsby James¹,Walden Andrew¹,Keating Liza¹,Frise Matthew¹,Rai Sabi¹,Bartley Shauna¹,Schuster-Bruce Martin¹,Pitts Sally¹,Miln Rebecca¹,Purandare Laura¹,Vamplew Luke¹,Patel Brijesh¹,Dempster Debra¹,Gummadi Mahitha¹,Dormand Natalie¹,Wang Shu¹,Spivey Michael¹,Bean Sarah¹,Burt Karen¹,Moore Lorraine¹,Hammonds Fiona¹,Richards Carol¹,Chapman Rachel¹,Cornell Thomas¹,Campbell Lewis¹,Smyth Kirsty¹,Ross Elizabeth¹,Mackenzie Brittney¹,Day Christopher¹,Zitter Letizia¹,Benyon Sarah¹,Singh Jayaprakash¹,Lynch Ceri ¹,Mikusek Justyna¹,Deacon Bethan¹,Turner Keri¹,Baker Evelyn¹,Hickey John¹,Champanerkar Shreekant¹,Aitken Lindianne ¹,LewisProsser Lorraine¹,Ahmad Norfaizan ¹,Wiles Matt¹,Willson Jayne¹,Grecu Irina¹,Martin Jane¹,Wrey Brown Caroline¹,Arias Ana-Marie¹,Bevan Emily¹,Westlake Samantha¹,Craven Thomas¹,Hope David¹,Singleton Jo¹,Clark Sarah¹,McCulloch Corrienne¹,Biddie Simon¹,Marshall Lucy¹,Birch Sophie¹,Britton Kate¹,Welters Ingeborg¹,Hamilton David¹,Williams Karen¹,Shaw David¹,Mulla Suleman¹,Waite Alicia¹,Roman Jaime¹,Martinez Maria¹,Johnston Brian¹,Medhurst Laura¹,Beresford Stephanie¹,Ayee Robert¹,Puthucheary Zudin¹,Martin Timothy¹,Santos Filipa¹,Uddin Ruzena ¹,Fernandez Maria¹,Seidu Fatima¹,Somerville Alastair¹,Pakats Mari-Liis¹,Begum Salma¹,Shahid Tasnin ¹,Dias Priya¹,Presneill Jeffrey¹,Barge Deborah¹,Byrne Kathleen¹,Vuylsteke Alain¹,Chan Charles¹,Victor Saji¹,Waterson Sharon¹,McNamara Robert¹,Boardman Melanie¹,Gattas David¹,Buhr Heidi¹,Coles Jennifer¹,Matsa Ramprasad¹,Gellamucho Minerva¹,Sernicola Elisa¹,Bailey Lucy¹,Creagh-Brown Ben¹,Marriot Cheryl¹,Salberg Armorel¹,Zouita Louisa¹,Stone Sarah¹,Michalak-Glinska Natalia¹,Donlon Sinead¹,Mtuwa Shelia¹,Mayangao Irving¹,Verula Jerik¹,Burda Dorota¹,Harris Celia¹,Jones Emily¹,Bradley Paul¹,Tarr Esther¹,Harden Lesley¹,Piercy Charlie¹,Smith Eleanor¹,Nolan Jerry¹,Kerslake Ian¹,Cook Tim¹,Simpson Tom¹,Dalton James¹,Demetriou Carrie¹,Mitchard Sarah¹,Ramos Lidia¹,White Katie¹,Johnson Toby¹,Headdon William¹,Spencer Stephen¹,White Alison¹,Howie Lucy¹,Smith Natalie¹,Riddell Phillip¹,Hierons Sarah¹,Evans Gabrielle¹,Didiodato Giulio¹,Igric Ana¹,Cruise Kelly¹,Ding Ian¹,Shelep Victoria¹,Pietersen Debra¹,Pokhrel Sujata¹,Reay Michael¹,Jenkins Steve¹,Watts Angela¹,Traverse Eleanor¹,Jennings Stacey¹,Anumakonda Vikram¹,Tuckwell Caroline¹,Harrow Kath¹,Matthews Julie¹,McGarry Karen¹,Moore Vanessa¹,Smith Lucie¹,Summerfield Anna¹,Dark Paul¹,Harvey Alice¹,Doonan Reece¹,McMorrow Liam¹,Knowles Karen¹,Pendlebury Jessica¹,Lee Stephanie¹,Perez Jane¹,Marsden Tracy¹,Taylor Melanie¹,Michael Angiy ¹,Collis Matthew¹,Claxton Andrew¹,Habeichi Wadih¹,Horner Dan¹,Slaughter Melanie¹,Thomas Vicky¹,Proudfoot Nicola¹,Keatley Claire¹,Mclaughlan Danielle¹,Donnison Phil¹,Casey Ruth¹,Irving Ben¹,Matimba-Mupaya Wadzanai¹,Reed Catherine¹,Anthony Alpha¹,Trim Fiona¹,Cambalova Lenka¹,Robertson Debra¹,Wilson Anna¹,Eapen Beena¹,Hulme Jonathan¹,Kannan Santhana¹,Kinney Fiona¹,Senya Ho¹,Hayes Anne¹,Diridis Kristina¹,Ramamurthi Balaji¹,Bleasdale John¹,Mokhtar Nabih¹,Newbould David¹,Arora Anand¹,Saluja Rupali¹,Sharma Deepak¹,Haiba Khalid¹,Donnelly Kieran¹,Sherwood Nick¹,Joseph Sibet¹,Potter Sarah¹,Henry Lavinia¹,Ratnam Valli¹,Gill Mandy¹,Kirk Jill¹,Shelton Sarah¹,Schweikert Sacha¹,Wibrow Bradley¹,Mevavala Bhaumik¹,Asif Namra¹,Khoso Nasir¹,Taqdees Huda¹,Frey Christian¹,Scano Riccardo¹,McKee Madeleine¹,Murphy Peter¹,Thomas Matt¹,Worner Ruth¹,Faulkner Beverley¹,Gendall Emma¹,Hayes Kati¹,Blakemore Hayley¹,Borislavova Borislava¹,Smith Kerry¹,Stephens Deanna¹,Deshpande Kush¹,van Haren Frank¹,Konecny Pam¹,Inskip Deborah¹,Tung Raymond¹,Hayes Leanne¹,Murphy Lorna¹,Neill Andy¹,Reidy Bryan¹,O’Dwyer Michael¹,Ryan Donal¹,Ainscough Kate¹,Hamilton-Davies Colin¹,Chan Carmen¹,Mfuko Celina¹,Abbass Hakam¹,Mandadapu Vineela¹,Leaver Susannah¹,Patel Kamal¹,Farnell-Ward Sarah¹,Saluzzio Romina¹,Rawlins Sam¹,Sicat Christine¹,Fernandes Edna¹,De Keulenaer Bart¹,Ferrier Janet¹,Fysh Ed¹,Dawda Ashlish¹,Al-Hazzani Waleed¹,Ligori Tania¹,Soth Mark¹,Clarke France¹,Matic Karlo¹,Copland Mary¹,Hoad Neala¹,Sawyer Ashley¹,Banach Dorota¹,Fernández de Pinedo Artaraz Ziortza ¹,Cabreros Leilani¹,Latham Victoria¹,Wong Jenny¹,Gurung Anita¹,Mohammed Amal¹,Jepson Eleanor¹,Kruisselbrink Rebecca¹,Brochard Laurent¹,Burns Karen¹,Sandhu Gyan¹,Khalid Imrana¹,White Ian¹,Croft Maria¹,Holland Nicky¹,Pereira Rita¹,Frost Victoria¹,Wells Karen¹,Chin Teri¹,Aquino Maia¹,Nair Priya¹,Buscher Hergen¹,Reynolds Claire¹,Campion Alexandra¹,Hall Amelia¹,Santamaria John¹,Haydon Tim¹,Homes Jennifer¹,Zaki Ahmed¹,Johnson David¹,Garrard Hywel¹,Juhaz Vera¹,Brown Louise¹,Pemberton Abigail¹,Roy Alistair¹,Rostron Anthony¹,Woods Lindsey¹,Cornell Sarah¹,Amaral Andre¹,Angriman Federico¹,Cuthbertson Brian¹,Fowler Rob¹,Piquette Dominique¹,Scales Damon¹,Tillman Bourke¹,Marinoff Nicole¹,Kaur Navjot¹,Adeel Zoya¹,Kamra Maneesha¹,Khan Hamzah¹,Murali Deeptha¹,Ruxandra Pinto¹,Sabananthan Thivya¹,Sugumaran Thuva¹,Garrett Peter¹,Murray Lauren¹,Brailsford Jane¹,Pillai Suresh¹,Harford Rachel¹,Ivatt Helen¹,Evans Debra¹,Richards Suzanne¹,Roberts Eilir¹,Bowen James¹,Ainsworth James¹,Williams Marie¹,Kuitunen Anne¹,Karlsson Sari¹,Vahtera Annukka¹,Kiiski Heikki¹,Ristimäki Sanna¹,Albrett Jonathan¹,Jackson Carolyn¹,Kirkham Simon¹,Tamme Kadri¹,Reinhard Veronika¹,Ellervee Anneli¹,Põldots Liisi¹,Rennit Pille¹,Svitškar Nikolai¹,Chen Jonathan¹,Miller Amanda¹,McCracken Phoebe¹,Young Meredith¹,Board Jasmin¹,Martin Emma¹,Kasipandian Vidya¹,Patel Amit¹,Allibone Suzanne¹,Mary-Genetu Roman¹,English Shane¹,Seely Andrew¹,McIntyre Lauralyn¹,Watpool Irene¹,Porteous Rebecca¹,Miezitis Sydney¹,Haines Jessica¹,Brady Kara¹,Vale Cassandra¹,Shekar Kiran¹,Lavana Jayshree¹,Parmar Dinesh¹,Peake Sandra¹,Williams Patricia¹,Kurenda Catherine¹,Wijewardena Gayathri¹,Hormis Anil¹,Walker Rachel¹,Collier Dawn¹,Kimpton Sarah¹,Oakley Susan¹,Graham Cheryl¹,Maynard Victoria¹,Bhagani Sanjay¹,De Neef Mark¹,Garcia Sara¹,Maharajh Amitaa ¹,Nandani Aarti¹,Dobson Jade¹,Fernando Gloria¹,Eastgate Christine¹,Gomez Keith¹,Abdi Zakee¹,Pakou Glykeria¹,Tatham Kate¹,Jhanji Shaman¹,Black Ethel¹,Dela Rosa Arnold¹,Howle Ryan¹,Baikady Ravishankar¹,Tully Redmond¹,Drummond Andrew¹,Dearden Joy¹,Philbin Jennifer¹,Munt Sheila¹,Gopal Shameer¹,Pooni Jagtar-Singh¹,Ganguly Saibal¹,Smallwood Andrew¹,Metherell Stella¹,Naeem Anas¹,Fagan Laura¹,Turner Elizabeth¹,Mariappa Vasanth¹,Smith Judith¹,Foulds Angela¹,Revill Adam¹,Bhattarai Binita¹,Maharjan Sabi¹,Maharjan Radhika¹,Phuyal Aarti¹,Shrestha Namrata¹,Meijer Karina¹,Postma Douwe¹,Thedinga Karen¹,de Jonge Evert¹,Wigbers Jeanette¹,del Prado Michael¹,Cremer Olaf¹,Mulier Jelle¹,Rademaker Emma¹,Peters Anna¹,Romberg Birgit¹,Leavis Helen¹,Schutgens Roger¹,Troeman Darren¹,van Opdorp Marjolein¹,Besten Henny¹,Brakké Karen¹,Barber Russell¹,Hilldrith Anette¹,Sloan Andrew¹,Okubanjo Maryanne¹,Francis Olesya¹,Barker Stephanie¹,Butler Susan¹,Hewitt Claire¹,Lee Kelvin¹,Tavares Silvia¹,Kluge Stefan¹,Nierhaus Axel¹,Jarczak Dominik¹,Roedl Kevin¹,Kochanek Matthias¹,Rueß-Paterno Giusi¹,Mc-Kenzie Josette¹,Eichenauer Dennis¹,Shimabukuro-Vornhagen Alexander¹,Göpel Siri¹,Eisenbeis Simone¹,Rissen Reimer¹,Conzelmann Nadine¹,Wilcox Elizabeth¹,del Sorbo Lorenzo¹,Abdelhady Hesham¹,Romagnuolo Tina¹,Simpson Scott¹,Maiden Matthew¹,Horton Michelle¹,Trickey Jemma¹,Brohi Farooq¹,Jagannathan Vijay¹,Clark Michele¹,Purvis Sarah¹,Wetherill Bill¹,Dushianthan Ahilanandan ¹,Cusack Rebecca¹,de Courcy-Golder Kim¹,Salmon Karen¹,Burnish Rachel¹,Smith Simon¹,Jackson Susan¹,Ruiz Winningtom ¹,Duke Zoe¹,Johns Magaret ¹,Male Michelle¹,Gladas Kirsty¹,Virdee Satwinder ¹,Swabe Jacqueline¹,Tomlinson Helen¹,Baker Alice¹,Carter Michael¹,Roberts Belinda¹,Greene Emma¹,Rohde Gernot¹,Grünewaldt Achim¹,Bojunga Jörg¹,Petros Sirak¹,Pasieka Bastian¹,Kunz Kevin¹,Laudi Sven¹,Seidel Antje¹,Ullmann Hannah¹,Schlegel Christian¹,Weismann Dirk¹,Frey Anna¹,Drayss Maria¹,Goebeler M.E.¹,Flor Thomas¹,Fragner Gertrud¹,Wahl Nadine¹,Totzke Juliane¹,Sayehli Cyrus¹,Bewley Jeremy¹,Sweet Katie¹,Grimmer Lisa¹,Johnson Rebekah¹,Wyatt Rachel¹,Morgan Karen¹,Varghese Siby¹,Willis Joanna¹,Stratton Emma¹,Kyle Laura¹,Putensen Daniel¹,Drury Kay¹,Skorko Agnieszka¹,Dell Abbie¹,Wright Kim¹,Webster Denise¹,Corcoran Kathleen¹,Kolovou Angeliki¹,Efford Georgia¹,McCullagh Liz¹,Bremmer Pamela¹,Ward Geraldine¹,Bassford Christopher¹,Sligl Wendy¹,Baig Nadia¹,Rewa Oleksa¹,Bagshaw Sean¹,Markota Andrej¹,Kalamar Žiga¹,Svenšek Franc¹,Marinšek Martin¹,Fluher Jure¹,Jerenec Katja¹,Kit Barbara¹,Živko Iris¹,Linstrum Kelsey¹,Basile Kim¹,Stavor Dara¹,Burbee Dylan¹,McNamara Amanda¹,Wunderley Renee¹,Bensen Nicole¹,Richardson Aaron¹,Adams Peter¹,Vita Tina¹,Buhay Megan¹,Scholl Denise¹,Gilliam Matthew¹,Winters James¹,Doherty Kaleigh¹,Berryman Emily¹,Ghaffari Mehrdad¹,Marroquin Oscar¹,Quinn Kevin¹,Garrard William¹,Kalchthaler Kyle¹,Beard Gregory¹,Skrtich Aimee¹,Bagavathy Kavitha¹,Drapola Debra¹,Wells Alan¹,Bryan-Morris Kayla¹,Arnold John¹,Reynolds Bob¹,Hussain Mahwish¹,Dunsavage Janice¹,Saiyed Salim¹,Hernandez Erik¹,Goldman John¹,Brown Cynthia¹,Comp Susan¹,Raczek James¹,Morris Jenny¹,Vargas Jr. Jesus¹,Weiss Daniel¹,Hensley Joseph¹,Kochert Erik¹,Wnuk Chris¹,Nemeth Christopher¹,Mowery Brent¹,Hutchinson Christina¹,Winters Lauren¹,McAdams David¹,Walker Gena¹,Minnier Tami¹,Wisniewski Mary¹,Mayak Katelyn¹,McCreary Erin¹,Martin Elise¹,Bariola Ryan¹,Viehman Alex¹,Daley Jessica¹,Lopus Alyssa¹,Schmidhofer Mark¹,Ambrosino Richard¹,Keen Sherbrina ¹,Toffalo Sue¹,Stambaugh Martha¹,Trimmer Ken¹,Perri Reno¹,Casali Sherry¹,Medva Rebecca¹,Massar Brent¹,Beyerl Ashley¹,Burkey Jason¹,Keeler Sheryl¹,Lowery Maryalyce¹,Oncea Lynne¹,Daugherty Jason¹,Sevilla Chanthou¹,Woelke Amy¹,Dice Julie¹,Weber Lisa¹,Roth Jason¹,Ferringer Cindy¹,Beer Deborah¹,Fesz Jessica¹,Carpio Lillian¹,Colin Gwenhael¹,Zinzoni Vanessa¹,Maquigneau Natacha¹,Henri-Lagarrigue Matthieu¹,Pouplet Caroline¹,Reill Lorenz¹,Distler Michael¹,Maselli Astrid¹,Martynoga Robert¹,Trask Kara¹,Butler Amelia¹,Newlands Jessica¹,Henderson Kelly¹,Attwood Ben¹,Parsons Penny¹,Campbell Bridget¹,Smith Alex¹,Hakak Sheeba¹,Murphy Aisling¹,Joyce Kirsten¹,Page Valerie¹,Zhao Xiao¹,Oza Deepali¹,Abrahamson Gail¹,Sheath Ben¹,Ellis Chiara¹,Guanco Mark¹,Hoxha Elvira¹,Hegazy Ahmed¹,Nordin Nazril¹,Denham Lynn¹,Young Paul¹,Lesona Eden¹,Navarra Leanlove¹,Delaney Kirsha¹,Marmol Joy¹,Latino Reece¹,Qiu Shan¹,Monaghan Maree¹,Rhodes Jonathan¹,Anderson Thomas¹,Morris Sheila¹,Madani Yasser¹,Nayyar Vineet¹,Bowen David¹,Kong Jing¹,Monzon Angelica¹,Fuchs Ralph¹,Lambert Bridget¹,Tai Charlotte¹,Thomas Amy¹,Keen Alexandra¹,Tierney Carey¹,Omer Nimca¹,Bacon Gina¹,Evans Amy¹,Binnie Alexandra¹,Powell Elizabeth¹,McMillan Alexandra¹,Luk Tracy¹,Aref Noah¹,Denmade Craig¹,Sadera Girendra ¹,Jacob Reni¹,Jones Cathy¹,Hughes Debbie¹,Elgendy Ahmad¹,Geng Wenli¹,Digby Stephen¹,Southern David¹,Reddy Harsha¹,Hulse Sarah¹,Campbell Andrew¹,Garton Mark¹,Watkins Claire¹,Smuts Sara¹,The Stephanie¹,Smith Oliver¹,Harris John¹,Quinn Alison¹,Simpson Benjamin¹,McMillan Catherine¹,Finch Cheryl¹,Hill Claire¹,Cooper Josh¹,Brittain Michael¹,Teo Hoon¹,Waddington Natalia¹,Budd Joanna¹,Small Charlotte¹,O’Leary Ryan¹,Birch Janine¹,Collins Emma¹,Holland Andrew¹,Alexander Peter¹,Felton Tim¹,Ferguson Susan¹,Sellers Katharine¹,Ward Luke¹,Bentley Andrew¹,Fiouni Sofia¹,Yates David¹,Birkinshaw Isobel¹,Kell Kay¹,Scott Zoe¹,Pearson Harriet¹,Wittekamp Bastiaan¹,Grady Bart¹,Platenkamp Ellen¹,Hashmi Madiha¹,Ali Maryam¹,Hassan Noor¹,Panjwani Ashok¹,Umrani Zulfiqar¹,Shaikh Mohiuddin¹,Siddiqui Ayesha¹,Ain Quratul¹,Kanwal Darakhshan¹,van Bree Sjoerd¹,Bouw-Ruiter Marianne¹,Osinga Margreet¹, van Zanten Arthur¹,Adhikari Neill KJ¹,Annane Djillali¹,Battista Marie-Claude¹,Cohen Dian¹,Cook Deborah¹,Day Andrew¹,Guyatt Gordon¹,Heyland Daren¹,Kanji Salmaan¹,Tirupakuzhi Vijayaraghavan Bharath Kumar¹,Lamontagne Francois¹,Masse Marie-Helene¹,McGuinness Shay¹,Menard Julie¹,Parke Rachael¹,Pinto Ruxandra¹,Sprague Sheila¹,Bouffard Lucie¹,Gritsas Ari¹,Buckingham Lisa¹,Têtu Amélie¹,Malenfant Francis¹,Turcotte Pierre¹,Al-Beidh Farah¹,Angus Derek¹,Annane Djillai¹,Arabi Yaseen¹,Beane Abigail¹,Berry Scott¹,Bhimani Zahra¹,Bonten Marc¹,Bradbury Charlotte¹,Brunkhorst Franck¹,Burrell Aidan¹,Buxton Meredith¹,Cecconi Maurizio¹,Cheng Allen¹,Cove Matthew¹,Derde Lennie¹,Escourt Lise¹,Goossens Herman¹,Gordon Anthony¹,Green Camron¹,Haniffa Rashan¹,Hill Thomas¹,Huang David¹,Ichihara Nao¹,Lawler Patrick¹,Marshall John¹,McArthur Colin¹,McAuley Daniel¹,McGQuilten Zoe¹,McVerry Bryan¹,Mouncey Paul¹,Murthy Srinivas¹,Nichol Alistair¹,Parker Jane¹,Reyes Luis Felipe¹,Rowan Kathryn¹,Saito Hiroki¹,Santos Marlene¹,Seymour Christopher¹,Shankar-Hari Manu¹,Turgeon Alexis¹,Turner Anne¹,Webb Steve¹,Zarychanski Ryan¹,McEldrew Rebecca¹,KC Shirish¹,Tolppa Timo¹,Rashan Sumayyah¹,Singh Vanessa¹,van Bentum-Puijk Wilma¹,Brugman Curt¹,Groeneveld Erika¹,Jafarzadeh Mina¹,Jongenelen Irene¹,Keijzer-Timmers Nicole¹,Kester Esmee¹,Koelink Maaike¹,Okundaye Clementina¹,Parker Lorraine¹,Patil Sonal¹,Peters Svenja¹,Rietveld Ilse¹,Sayada Sarah¹,Smit Albertine¹,van Amerongen Roosmarijn¹,Vermont - van der Staaij Janine¹,Doran Peter¹,Anjum Aisha ¹,Au Carly¹,Lane Janis-Best¹,Fagboden Elizabeth¹,Barton Frances¹,Charles Walton¹,Miller Lorna¹,Parry-Billings Karen¹,Peters Sam¹,Richards-Belle Alvin¹,Saull Michelle¹,Sprinckmoller Stefan¹,Wiley Daisy¹,Darnell Robert¹,Stronach Lucy¹,Wada Asako¹,Beqaj Besa¹,Forbes Andrew¹,Green Cameron¹,Heritier Stephane¹,Hills Thomas¹,McEldrew Bec¹,McQuilten Zoe¹,Trapani Tony¹,Manoharan Venika¹,Dondrop Arjen M¹,Bin Hasan Mohd Shahnaz¹,Jayakumar Devachandran¹,Kalla Ismail ¹,Murray Lyle¹,Siika Wangari¹,Brunkhorst Frank¹,Ehrmann Stephan¹,Povoa Pedro¹,Horvat Chrisptopher¹,Doi Yohei¹,Fujitani Shigeki¹,Honda Hitoshi¹,Jindai Kazuaki¹,Kamata Kazuhiro¹,Kato Hideaki¹,Kunishima Hiroyuki¹,Nakazono Kenichi¹,Shintani Ayumi¹,Yamagishi Yoshiaki¹,Yamashita Chizuru¹,Beasley Richard¹,Daneman Nick¹,Fowler Robert¹,McGloughlin Steve¹,Paterson David¹,Hullegie Sebastiaan¹,Litton Edward¹,Murphy Srinivas¹,Venkatesh Bala¹,de Jong Menno¹,Uyeki Tim¹,Baillie Kenneth¹,Netea Mihai¹,Orr Katrina¹,Patanwala Asad¹,Tong Steve¹,Cooper Nichola¹,Galea James¹,Ogungbenro Kayode¹,Patawala Asad¹,Tong Steven¹,Youngstein Taryn¹,Carrier Marc¹,Fergusson Dean¹,Goligher Ewan¹,Hunt Beverley¹,Kumar Anand¹,Laffan Mike¹,Lother Sylvain¹,Middledorp Saskia¹,Neal Matthew¹,Stanworth Simon¹,Anstey Matthew¹,de Man Angelique¹,Udy Andrew¹,Abraham Jacinta¹,Arnold Donald¹,Begin Phillipe¹,Charlewood Richard¹,Chasse Michael¹,Cooper Jamie¹,Coyne Mark¹,Daly James¹,Estcourt Lise¹,Gosbell Iain¹,Harvala-Simmonds Heli¹,Hills Tom¹,MacLennan Sheila¹,McDyer John¹,Menon David¹,Pridee Nicole¹,Roberts David¹,Thomas Helen¹,Tinmouth Alan¹,Triulzi Darrell¹,Walsh Tim¹,Wood Erica¹,Calfee Carolyn¹,O’Kane Cecilia¹,Shyamsundar Murali¹,Sinha Pratik¹,Thompson Taylor¹,Young Ian¹,Ferguson Niall¹,Hodgson Carol¹,Neto Ary¹,Orford Neil¹,Phua Jason¹,Baron Rebecca¹,Epelman Slava ¹,Ezekowitz Justin¹,Frankfurter Claudia ¹,Gommans Frank ¹,Kwan Yvonne¹,Kim Edy¹,Leaf David ¹,Owen David¹,Pollock Katrina¹,Puskarich Michael¹,Vaduganathan Muthiah¹,van Kimmenade Roland¹,Harrison David¹,Higgins Alisa¹,Lampro Lamprini¹,Mason Alexina¹,Mila de la Fuente Gema¹,Leffelaar Evelien¹,Schotsman Joost¹,Boyd Craig¹,Harland Cain¹,Shearer Audrey¹,Wren Jess¹,Clermont Giles¹,Ricketts Daniel¹,Fazla Fathima¹,Muvindi Himasha¹,Ishani Pramodya¹,Rashan Aasiyah¹,Udayanga Ishara ¹,Detry Michelle¹,Fitzgerald Mark¹,Lewis Roger¹,McGlothlin Anna¹,Saunders Christina¹,Berry Lindsay¹,Lorenzi Elizabeth¹,Adhikari Neill K. J.²³,Hashmi Madiha⁴,Tirupakuzhi Vijayaraghavan Bharath Kumar⁵⁶,Haniffa Rashan⁷⁸,Beane Abi⁷⁸,Webb Steve A.⁹¹⁰,Angus Derek C.¹¹¹²,Gordon Anthony C.¹³¹⁴,Cook Deborah J.¹⁵¹⁶¹⁷,Guyatt Gordon H.¹⁷,Berry Lindsay R.¹⁸,Lorenzi Elizabeth¹⁸,Mouncey Paul R.¹⁹,Au Carly¹⁹,Pinto Ruxandra²,Ménard Julie²⁰,Sprague Sheila²¹,Masse Marie-Hélène²⁰,Huang David T.²²,Heyland Daren K.²³,Nichol Alistair D.⁹²⁴²⁵²⁶,McArthur Colin J.²⁷,de Man Angelique²⁸,Al-Beidh Farah²⁹,Annane Djillali³⁰³¹,Anstey Matthew³²³³,Arabi Yaseen M.³⁴³⁵,Battista Marie-Claude²⁰,Berry Scott¹⁸,Bhimani Zahra³⁶,Bonten Marc J. M.³⁷³⁸,Bradbury Charlotte A.³⁹,Brant Emily B.⁴⁰,Brunkhorst Frank M.⁴¹,Burrell Aidan²⁶⁴²,Buxton Meredith⁴³,Cecconi Maurizio⁴⁴⁴⁵,Cheng Allen C.⁴⁶⁴⁷,Cohen Dian⁴⁸⁴⁹,Cove Matthew E.⁵⁰,Day Andrew G.⁵¹,Derde Lennie P. G.³⁸⁵²,Detry Michelle A.¹⁸,Estcourt Lise J.⁵³⁵⁴,Fagbodun Elizabeth O.⁵⁵,Fitzgerald Mark¹⁸,Goossens Herman⁵⁶,Green Cameron⁹,Higgins Alisa M.⁹,Hills Thomas E.⁵⁷,Ichihara Nao⁵⁸,Jayakumar Devachandran⁵⁹,Kanji Salmaan⁶⁰⁶¹,Khoso Muhammad Nasir⁶²,Lawler Patrick R.⁶³⁶⁴⁶⁵,Lewis Roger J.¹⁸,Litton Edward⁶⁶,Marshall John C.⁶⁷,McAuley Daniel F.⁶⁸⁶⁹,McGlothlin Anna¹⁸,McGuinness Shay P.⁵⁷⁷⁰⁷¹,McQuilten Zoe K.⁷²,McVerry Bryan J.⁷³,Murthy Srinivas⁷⁴,Parke Rachael L.⁵⁷⁷⁰⁷⁵,Parker Jane C.²⁴,Reyes Luis Felipe⁷⁶⁷⁷,Rowan Kathryn M.¹⁹,Saito Hiroki⁷⁸,Salahuddin Nawal⁷⁹,Santos Marlene S.⁸⁰,Saunders Christina T.¹⁸,Seymour Christopher W.⁴⁰,Shankar-Hari Manu⁸¹⁸²,Tolppa Timo⁸³,Trapani Tony⁷¹,Turgeon Alexis F.⁸⁴⁸⁵,Turner Anne M.⁵⁷,Udy Andrew A.⁷¹⁸⁶,van de Veerdonk Frank L.⁸⁷,Zarychanski Ryan⁸⁸,Lamontagne François²⁰⁸⁹

Affiliation:

1. The LOVIT-COVID Investigators, on behalf of the Canadian Critical Care Trials Group, and the REMAP-CAP Investigators

2. Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

3. Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada

4. Department of Critical Care Medicine, Ziauddin University, Karachi, Pakistan

5. Department of Critical Care Medicine, Apollo Hospitals, Chennai, India

6. George Institute for Global Health India, New Delhi

7. Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, Scotland

8. Mahidol Oxford Tropical Medicine Research Unit, Bangkok, Thailand

9. Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia

10. St John of God Health Care, Perth, Australia

11. University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania

12. University of Pittsburgh, Pittsburgh, Pennsylvania

13. Division of Anaesthetics, Pain Medicine, and Intensive Care, Imperial College London, London, England

14. St Mary’s Hospital, Imperial College Healthcare NHS Trust, London, England

15. Department of Medicine, McMaster University, Hamilton, Ontario, Canada

16. Department of Critical Care, St Joseph’s Healthcare Hamilton, Hamilton, Ontario, Canada

17. Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada

18. Berry Consultants LLC, Austin, Texas

19. Intensive Care National Audit and Research Centre, London, England

20. Research Centre of the Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada

21. Department of Surgery, McMaster University, Hamilton, Ontario, Canada

22. School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania

23. Department of Critical Care Medicine, Queen’s University, Kingston, Ontario, Canada

24. Faculty of Medicine, Nursing, and Health Sciences, Monash University, Clayton, Australia

25. University College Dublin, Dublin, Ireland

26. Alfred Health, Melbourne, Australia

27. Department of Critical Care Medicine, Auckland City Hospital, Auckland, New Zealand

28. Department of Intensive Care Medicine, Amsterdam University Medical Centers, Amsterdam, the Netherlands

29. Imperial College London, London, England

30. UVSQ University Paris Saclay, Institut-Hospitalo Universitaire Prometheus, Paris, France

31. Médecine Intensive-Réanimation, Hôpital Raymond-Poincaré, Garches, France

32. Sir Charles Gairdner Hospital, Nedlands, Australia

33. University of Western Australia, Perth

34. King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia

35. King Abdullah International Medical Research Center, Riyadh, Saudi Arabia

36. St Michael’s Hospital, Unity Health Toronto, Toronto, Ontario, Canada

37. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands

38. European Clinical Research Alliance on Infectious Diseases, Utrecht, the Netherlands

39. University of Bristol, Bristol, England

40. Department of Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania

41. Department of Anaesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany

42. Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia

43. Global Coalition for Adaptive Research, Larkspur, California

44. Department of Biomedical Sciences, Humanitas University, Milan, Italy

45. IRCCS Humanitas Research Hospital, Milan, Italy

46. Monash Infectious Disease, Monash Health and School of Clinical Sciences, Monash University, Clayton, Australia

47. School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia

48. Bishop’s University, Sherbrooke, Quebec, Canada

49. Massawippi Valley Foundation, Ayer’s Cliff, Quebec, Canada

50. Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

51. Kingston Health Sciences Centre and Queen’s University, Kingston, Ontario, Canada

52. Intensive Care Centre, University Medical Centre Utrecht, Utrecht, the Netherlands

53. Department of Haematology, NHS Blood and Transplant, Bristol, England

54. Radcliffe Department of Medicine, University of Oxford, Oxford, England

55. Imperial Clinical Trials Unit, Imperial College London, London, England

56. Laboratory of Medical Microbiology, University of Antwerp, Antwerp, Belgium

57. Medical Research Institute of New Zealand, Wellington

58. Department of Cardiovascular Surgery, School of Medicine, Jikei University, Tokyo, Japan

59. Dr Kamakshi Memorial Hospital Apollo, Chennai, India

60. Ottawa Hospital, Ottawa, Ontario, Canada

61. Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

62. South City Hospital, Karachi, Pakistan

63. University Health Network, Toronto, Ontario, Canada

64. University of Toronto, Toronto, Ontario, Canada

65. McGill University Health Centre, Montreal, Quebec, Canada

66. Fiona Stanley Hospital, Department of Intensive Care Unit, University of Western Australia, Perth

67. Department of Surgery, University of Toronto, Toronto, Ontario, Canada

68. Queen’s University of Belfast, Belfast, Northern Ireland

69. Centre for Infection and Immunity, Royal Victoria Hospital, Belfast, Northern Ireland

70. Auckland City Hospital, Cardiothoracic and Vascular Intensive Care Unit, Auckland, New Zealand

71. Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Australia

72. Monash University, Monash Health, Clayton, Australia

73. Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania

74. Department of Pediatrics, University of British Columbia, Vancouver, Canada

75. School of Nursing, University of Auckland, Auckland, New Zealand

76. Department of Infectious Diseases, Universidad de La Sabana, Chia, Colombia

77. Department of Critical Care Medicine, Clinica Universidad de La Sabana, Chia, Colombia

78. Department of Emergency and Critical Care Medicine, St Marianna University Yokohama Seibu Hospital, Yokohama, Japan

79. National Institute of Cardiovascular Diseases, Karachi, Pakistan

80. Department of Critical Care, St Michael’s Hospital, Toronto, Ontario, Canada

81. Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, Scotland

82. Royal Infirmary of Edinburgh, NHS Lothian, Edinburgh, Scotland

83. National Intensive Care Surveillance, Colombo, Sri Lanka

84. Department of Anesthesiology and Critical Care, Université Laval, Quebec City, Quebec, Canada

85. Population Health and Optimal Health Practices Research Unit, Departments of Traumatology, Emergency Medicine, and Critical Care Medicine, Université Laval Research Center, CHU de Québec-Université Laval, Quebec City, Quebec, Canada

86. Department of Intensive Care and Hyperbaric Medicine, Alfred Hospital, Melbourne, Australia

87. Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands

88. Department of Internal Medicine, University of Manitoba, Winnipeg, Canada

89. Department of Medicine, Université de Sherbrooke, Sherbrooke, Quebec, Canada

Abstract

ImportanceThe efficacy of vitamin C for hospitalized patients with COVID-19 is uncertain.ObjectiveTo determine whether vitamin C improves outcomes for patients with COVID-19.Design, Setting, and ParticipantsTwo prospectively harmonized randomized clinical trials enrolled critically ill patients receiving organ support in intensive care units (90 sites) and patients who were not critically ill (40 sites) between July 23, 2020, and July 15, 2022, on 4 continents.InterventionsPatients were randomized to receive vitamin C administered intravenously or control (placebo or no vitamin C) every 6 hours for 96 hours (maximum of 16 doses).Main Outcomes and MeasuresThe primary outcome was a composite of organ support–free days defined as days alive and free of respiratory and cardiovascular organ support in the intensive care unit up to day 21 and survival to hospital discharge. Values ranged from –1 organ support–free days for patients experiencing in-hospital death to 22 organ support–free days for those who survived without needing organ support. The primary analysis used a bayesian cumulative logistic model. An odds ratio (OR) greater than 1 represented efficacy (improved survival, more organ support–free days, or both), an OR less than 1 represented harm, and an OR less than 1.2 represented futility.ResultsEnrollment was terminated after statistical triggers for harm and futility were met. The trials had primary outcome data for 1568 critically ill patients (1037 in the vitamin C group and 531 in the control group; median age, 60 years [IQR, 50-70 years]; 35.9% were female) and 1022 patients who were not critically ill (456 in the vitamin C group and 566 in the control group; median age, 62 years [IQR, 51-72 years]; 39.6% were female). Among critically ill patients, the median number of organ support–free days was 7 (IQR, −1 to 17 days) for the vitamin C group vs 10 (IQR, −1 to 17 days) for the control group (adjusted proportional OR, 0.88 [95% credible interval {CrI}, 0.73 to 1.06]) and the posterior probabilities were 8.6% (efficacy), 91.4% (harm), and 99.9% (futility). Among patients who were not critically ill, the median number of organ support–free days was 22 (IQR, 18 to 22 days) for the vitamin C group vs 22 (IQR, 21 to 22 days) for the control group (adjusted proportional OR, 0.80 [95% CrI, 0.60 to 1.01]) and the posterior probabilities were 2.9% (efficacy), 97.1% (harm), and greater than 99.9% (futility). Among critically ill patients, survival to hospital discharge was 61.9% (642/1037) for the vitamin C group vs 64.6% (343/531) for the control group (adjusted OR, 0.92 [95% CrI, 0.73 to 1.17]) and the posterior probability was 24.0% for efficacy. Among patients who were not critically ill, survival to hospital discharge was 85.1% (388/456) for the vitamin C group vs 86.6% (490/566) for the control group (adjusted OR, 0.86 [95% CrI, 0.61 to 1.17]) and the posterior probability was 17.8% for efficacy.Conclusions and RelevanceIn hospitalized patients with COVID-19, vitamin C had low probability of improving the primary composite outcome of organ support–free days and hospital survival.Trial RegistrationClinicalTrials.gov Identifiers: NCT04401150 (LOVIT-COVID) and NCT02735707 (REMAP-CAP)

Publisher

American Medical Association (AMA)

Subject

General Medicine

Link

https://jamanetwork.com/journals/jama/articlepdf/2811212/jama_adhikari_2023_oi_230127_1702498690.6766.pdf

Reference30 articles.

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2. The global COVID-19 treatment divide.;Usher;Lancet,2022

3. Use of hydrocortisone, ascorbic acid, and thiamine in adults with septic shock.;Vail;Am J Respir Crit Care Med,2020

4. Effect of vitamin C, hydrocortisone, and thiamine vs hydrocortisone alone on time alive and free of vasopressor support among patients with septic shock: the VITAMINS randomized clinical trial.;Fujii;JAMA,2020

5. Effect of vitamin C, thiamine, and hydrocortisone on ventilator- and vasopressor-free days in patients with sepsis: the VICTAS randomized clinical trial.;Sevransky;JAMA,2021

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Revisions to Nonauthor Collaborator Names;JAMA;2023-12-26

2. Vitamin C for Patients With COVID-19;JAMA;2023-11-14