Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype

Author:

Ma Yiyi123,Jun Gyungah R.14,Zhang Xiaoling1,Chung Jaeyoon1,Naj Adam C.5,Chen Yuning4,Bellenguez Celine6,Hamilton-Nelson Kara7,Martin Eden R.7,Kunkle Brian W.7,Bis Joshua C.8,Debette Stéphanie910,DeStefano Anita L.411,Fornage Myriam12,Nicolas Gaël131415,van Duijn Cornelia16,Bennett David A.17,De Jager Philip L.231819,Mayeux Richard3,Haines Jonathan L20,Pericak-Vance Margaret A.7,Seshadri Sudha112122,Lambert Jean-Charles6,Schellenberg Gerard D.5,Lunetta Kathryn L.4,Farrer Lindsay A.14112324,

Affiliation:

1. Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston, Massachusetts

2. Center for Translational & Computational Neuroimmunology, Multiple Sclerosis Clinical Care and Research Center, Division of Neuroimmunology, Columbia University Medical Center, New York, New York

3. Department of Neurology, Columbia University Medical Center, New York, New York

4. Department of Biostatistics, Boston University Schools of Medicine and Public Health, Boston, Massachusetts

5. Perelman School of Medicine, University of Pennsylvania, Philadelphia

6. Universite de Lille, INSERM UMR1167, Institute Pasteur de Lille, Lille, France

7. John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida

8. Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle

9. Bordeaux Population Health Research Center, UMR1219, University Bordeaux, Inserm, Bordeaux, France

10. Department of Neurology, Bordeaux University Hospital, Bordeaux, France

11. Department of Neurology, Boston University Schools of Medicine and Public Health, Boston, Massachusetts

12. School of Public Health, University of Texas Health Science Center at Houston, Houston

13. UNIROUEN, Inserm U1245, Normandie University, Rouen, France

14. Department of Genetics, Rouen University Hospital, Rouen, France

15. Normandy Centre for Genomic and Personalized Medicine, Centre National de Référence pour les Malades Alzheimer Jeunes, Rouen, France

16. Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands

17. Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, Illinois

18. Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts

19. Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts

20. Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio

21. National Heart, Lung, and Blood Institute’s Framingham Heart Study, Framingham, Massachusetts

22. Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio

23. Department of Ophthalmology, Boston University Schools of Medicine and Public Health, Boston, Massachusetts

24. Department of Epidemiology, Boston University Schools of Medicine and Public Health, Boston, Massachusetts

Publisher

American Medical Association (AMA)

Subject

Clinical Neurology

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