Efficacy and Safety of Lanabecestat for Treatment of Early and Mild Alzheimer Disease

Author:

Wessels Alette M.1,Tariot Pierre N.2,Zimmer Jennifer A.1,Selzler Katherine J.1,Bragg Sonja M.1,Andersen Scott W.1,Landry John1,Krull James H.1,Downing AnnCatherine M.1,Willis Brian A.1,Shcherbinin Sergey1,Mullen Jamie34,Barker Peter3,Schumi Jennifer3,Shering Craig3,Matthews Brandy R.1,Stern Robert A.5,Vellas Bruno6,Cohen Sharon7,MacSweeney Emer8,Boada Mercè910,Sims John R.1

Affiliation:

1. Eli Lilly and Company, Indianapolis, Indiana

2. Banner Alzheimer’s Institute, University of Arizona College of Medicine, Phoenix

3. AstraZeneca, Waltham, Massachusetts, and Gaithersburg, Maryland

4. Now retired

5. Alzheimer’s Disease Center, Boston University School of Medicine, Boston, Massachusetts

6. Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Unités Mixtes de Recherche Institut National de la Santé et de la Recherche Médicale 1027, Université Toulouse III–Paul Sabatier, Toulouse, France

7. Toronto Memory Program, Toronto, Ontario, Canada

8. Re:Cognition Health, London, United Kingdom

9. Research Center and Memory Clinic, Fundació Alzheimer Centre Educacional, Institut Català de Neurociències Aplicades, Barcelona–Universitat Internacional de Catalunya, Barcelona, Spain

10. Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain

Publisher

American Medical Association (AMA)

Subject

Clinical Neurology

Reference32 articles.

1. Epidemiology of Alzheimer disease.;Reitz;Nat Rev Neurol,2011

2. Alzheimer’s disease.;Masters;Nat Rev Dis Primers,2015

3. Pathogenesis of Alzheimer’s disease: molecular and cellular mechanisms [in French].;Govaerts;Rev Med Liege,2007

4. Intracellular amyloid-ß in Alzheimer’s disease.;LaFerla;Nat Rev Neurosci,2007

5. AZD3293: pharmacokinetic and pharmacodynamic effects in healthy subjects and patients with Alzheimer’s disease.;Cebers;J Alzheimers Dis,2017

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