Abandoning the Proteinopathy Paradigm in Parkinson Disease-Reference-Cited by-同舟云学术

Abandoning the Proteinopathy Paradigm in Parkinson Disease

Published:2023-02-01 Issue:2 Volume:80 Page:123
ISSN:2168-6149
Container-title:JAMA Neurology
language:en
Short-container-title:JAMA Neurol

Author:

Espay Alberto J.¹,Okun Michael S.²

Affiliation:

1. James J. and Joan A. Gardner Family Center for Parkinson’s Disease and Movement Disorders, Department of Neurology, University of Cincinnati, Cincinnati, Ohio

2. Department of Neurology, Norman Fixel Institute for Neurological Diseases, Gainesville, Florida

Abstract

This Viewpoint makes a case for changing the approach in Parkinson disease research efforts from one of proteinopathy (accrual of amyloids) to proteinopenia (depletion of normal proteins).

Publisher

American Medical Association (AMA)

Subject

Neurology (clinical)

Link

https://jamanetwork.com/journals/jamaneurology/articlepdf/2799082/jamaneurology_espay_2022_vp_220021_1676273678.20281.pdf

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